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  1. 010 学術雑誌論文
  2. 印南, 秀樹 / INNAN, Hideki

The Amounts of Nucleotide Variation Within and Between Allelic Classes and the Reconstruction of the Common Ancestral Sequence in a Population

https://ir.soken.ac.jp/records/4407
https://ir.soken.ac.jp/records/4407
27328441-702f-4f70-9fcc-ccd22d6d8fa8
Item type 学術雑誌論文 / Journal Article(1)
公開日 2014-04-15
タイトル
タイトル The Amounts of Nucleotide Variation Within and Between Allelic Classes and the Reconstruction of the Common Ancestral Sequence in a Population
タイトル
タイトル The Amounts of Nucleotide Variation Within and Between Allelic Classes and the Reconstruction of the Common Ancestral Sequence in a Population
言語 en
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 INNAN, Hideki

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INNAN, Hideki

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TAJIMA, Fumio

× TAJIMA, Fumio

TAJIMA, Fumio

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著者別名 印南, 秀樹

× 印南, 秀樹

印南, 秀樹

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抄録
内容記述タイプ Abstract
内容記述 The amounts of nucleotide variation within and between allelic classes were studied. The expectation and variance of the number of segregating sites and the expectation of the average number of pairwise differences among a sample of DNA sequences were obtained by using the theory of gene genealogy with no recombination. When the ancestral allelic class is unknown, it was found that the amount of variation within an allelic class increases with its frequency in the sample, while the amount of variation between two allelic classes is the largest when the two allelic classes exist equally. On the other hand, if we know the ancestral allelic class, as the frequency of the mutant allelic class increases, the amounts of variation within the mutant allelic class and between two allelic classes increase and the amount of variation within the ancestral allelic class decreases. As an example, we analyzed the polymorphism in the ND5 gene of Drosophila melanogaster and constructed the common ancestral sequence with high confidence, suggesting that the pattern of polymorphism within species gives useful information to know the ancestral sequence of the species.
書誌情報 Genetics
en : Genetics

巻 147, 号 3, p. 1431-1444, 発行日 1997-11-01
出版者
出版者 The Genetics Society of America
ISSN
収録物識別子タイプ ISSN
収録物識別子 0016-6731
権利
権利情報 © 1997 by The Genetics Society of America
関連サイト
識別子タイプ URI
関連識別子 http://www.genetics.org/content/genetics/147/3/1431.full.pdf
関連名称 The Genetics Society of America
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