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The Amounts of Nucleotide Variation Within and Between Allelic Classes and the Reconstruction of the Common Ancestral Sequence in a Population
https://ir.soken.ac.jp/records/4407
https://ir.soken.ac.jp/records/440727328441-702f-4f70-9fcc-ccd22d6d8fa8
| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||
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| 公開日 | 2014-04-15 | |||||||||
| タイトル | ||||||||||
| タイトル | The Amounts of Nucleotide Variation Within and Between Allelic Classes and the Reconstruction of the Common Ancestral Sequence in a Population | |||||||||
| タイトル | ||||||||||
| タイトル | The Amounts of Nucleotide Variation Within and Between Allelic Classes and the Reconstruction of the Common Ancestral Sequence in a Population | |||||||||
| 言語 | en | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | journal article | |||||||||
| アクセス権 | ||||||||||
| アクセス権 | metadata only access | |||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||||||
| 著者 |
INNAN, Hideki
× INNAN, Hideki
× TAJIMA, Fumio
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| 著者別名 |
印南, 秀樹
× 印南, 秀樹
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| 抄録 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | The amounts of nucleotide variation within and between allelic classes were studied. The expectation and variance of the number of segregating sites and the expectation of the average number of pairwise differences among a sample of DNA sequences were obtained by using the theory of gene genealogy with no recombination. When the ancestral allelic class is unknown, it was found that the amount of variation within an allelic class increases with its frequency in the sample, while the amount of variation between two allelic classes is the largest when the two allelic classes exist equally. On the other hand, if we know the ancestral allelic class, as the frequency of the mutant allelic class increases, the amounts of variation within the mutant allelic class and between two allelic classes increase and the amount of variation within the ancestral allelic class decreases. As an example, we analyzed the polymorphism in the ND5 gene of Drosophila melanogaster and constructed the common ancestral sequence with high confidence, suggesting that the pattern of polymorphism within species gives useful information to know the ancestral sequence of the species. | |||||||||
| 書誌情報 |
Genetics en : Genetics 巻 147, 号 3, p. 1431-1444, 発行日 1997-11-01 |
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| 出版者 | ||||||||||
| 出版者 | The Genetics Society of America | |||||||||
| ISSN | ||||||||||
| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 0016-6731 | |||||||||
| 権利 | ||||||||||
| 権利情報 | © 1997 by The Genetics Society of America | |||||||||
| 関連サイト | ||||||||||
| 識別子タイプ | URI | |||||||||
| 関連識別子 | http://www.genetics.org/content/genetics/147/3/1431.full.pdf | |||||||||
| 関連名称 | The Genetics Society of America | |||||||||
