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A Method for Estimating the Mutation, Gene Conversion and Recombination Parameters in Small Multigene Families
https://ir.soken.ac.jp/records/4421
https://ir.soken.ac.jp/records/44215f162766-e3ce-4cdc-b764-1ac0b1fee873
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2014-04-17 | |||||
| タイトル | ||||||
| タイトル | A Method for Estimating the Mutation, Gene Conversion and Recombination Parameters in Small Multigene Families | |||||
| タイトル | ||||||
| タイトル | A Method for Estimating the Mutation, Gene Conversion and Recombination Parameters in Small Multigene Families | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
INNAN, Hideki
× INNAN, Hideki |
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| 著者別名 |
印南, 秀樹
× 印南, 秀樹 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | A simple two-locus gene conversion model is considered to investigate the amounts of DNA variation and linkage disequilibrium in small multigene families. The exact solutions for the expectations and variances of the amounts of variation within and between two loci are obtained. It is shown that gene conversion increases the amount of variation within each locus and decreases the amount of variation between two loci. The expectation and variance of the amount of linkage disequilibrium are also obtained. Gene conversion generates positive linkage disequilibrium and the degree of linkage disequilibrium decreases as the recombination rate is increased. Using the theoretical results, a method for estimating the mutation, gene conversion, and recombination parameters is developed and applied to the data of the Amy multigene family in Drosophila melanogaster. The gene conversion rate is estimated to be ∼60–165 times higher than the mutation rate for synonymous sites. | |||||
| 書誌情報 |
Genetics en : Genetics 巻 161, 号 2, p. 865-872, 発行日 2002-06-01 |
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| 出版者 | ||||||
| 出版者 | The Genetics Society of America | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0016-6731 | |||||
| 権利 | ||||||
| 権利情報 | © 2002 by The Genetics Society of America | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.genetics.org/content/genetics/161/2/865.full.pdf | |||||
| 関連名称 | The Genetics Society of America | |||||
