| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2014-04-17 |
| タイトル |
|
|
タイトル |
The Pattern of Polymorphism on Human Chromosome 21 |
| タイトル |
|
|
タイトル |
The Pattern of Polymorphism on Human Chromosome 21 |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
INNAN, Hideki
PADHUKASAHASAHASRAM, Badri
NORDBORG, Magnus
|
| 著者別名 |
印南, 秀樹
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Polymorphism data from 20 partially resequenced copies of human chromosome 21—more than 20,000 polymorphic sites—were analyzed. The allele-frequency distribution shows no deviation from the simplest population genetic model with a constant population size (although we show that our analysis has no power to detect population growth). The average rate of recombination per site is estimated to be roughly one-half of the rate of mutation per site, again in agreement with simple model predictions. However, sliding-window analyses of the amount of polymorphism and the extent of linkage disequilibrium (LD) show significant deviations from standard models. This could be due to the history of selection or demographic change, but it is impossible to draw strong conclusions without much better knowledge of variation in the relationship between genetic and physical distance along the chromosome. |
| 書誌情報 |
Genome Research
en : Genome Research
号 13,
p. 1158-1168,
発行日 2003
|
| 出版者 |
|
|
出版者 |
Cold Spring Harbor Laboratory Press |
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1088-9051 |
| DOI |
|
|
関連タイプ |
isIdenticalTo |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
http://doi.org/10.1101/gr.466303 |
|
|
関連名称 |
10.1101/gr.466303 |
| 権利 |
|
|
権利情報 |
©2003 by Cold Spring Harbor Laboratory Press |
| 関連サイト |
|
|
|
識別子タイプ |
URI |
|
|
関連識別子 |
http://genome.cshlp.org/site/misc/ifora.xhtml |
|
|
関連名称 |
Copyright |
| フォーマット |
|
|
内容記述タイプ |
Other |
|
内容記述 |
application/pdf |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
1158.full (3.7 MB)
