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  1. 010 学術雑誌論文
  2. 印南, 秀樹 / INNAN, Hideki

The effect of gene conversion on the divergence between duplicated genes

https://ir.soken.ac.jp/records/4441
https://ir.soken.ac.jp/records/4441
387d8930-e3c3-4a3a-b1df-4659e847331a
Item type 学術雑誌論文 / Journal Article(1)
公開日 2014-04-21
タイトル
タイトル The effect of gene conversion on the divergence between duplicated genes
タイトル
タイトル The effect of gene conversion on the divergence between duplicated genes
言語 en
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 TESHIMA, Kosuke M.

× TESHIMA, Kosuke M.

TESHIMA, Kosuke M.

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INNAN, Hideki

× INNAN, Hideki

INNAN, Hideki

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著者別名 印南 , 秀樹

× 印南 , 秀樹

印南 , 秀樹

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抄録
内容記述タイプ Abstract
内容記述 Nonindependent evolution of duplicated genes is called concerted evolution. In this article, we study the evolutionary process of duplicated regions that involves concerted evolution. The model incorporates mutation and gene conversion: the former increases d, the divergence between two duplicated regions, while the latter decreases d. It is demonstrated that the process consists of three phases. Phase I is the time until d reaches its equilibrium value, d0. In phase II d fluctuates around d0, and d increases again in phase III. Our simulation results demonstrate that the length of concerted evolution (i.e., phase II) is highly variable, while the lengths of the other two phases are relatively constant. It is also demonstrated that the length of phase II approximately follows an exponential distribution with mean τ, which is a function of many parameters including gene conversion rate and the length of gene conversion tract. On the basis of these findings, we obtain the probability distribution of the level of divergence between a pair of duplicated regions as a function of time, mutation rate, and τ. Finally, we discuss potential problems in genomic data analysis of duplicated genes when it is based on the molecular clock but concerted evolution is common.
書誌情報 Genetics
en : Genetics

巻 166, 号 3, p. 1553-1560, 発行日 2004-03-01
出版者
出版者 The Genetics Society of America
ISSN
収録物識別子タイプ ISSN
収録物識別子 0016-6731
権利
権利情報 © 2004 by The Genetics Society of America
関連サイト
識別子タイプ URI
関連識別子 http://www.genetics.org/content/genetics/166/3/1553.full.pdf
関連名称 The Genetics Society of America
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