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The effect of gene conversion on the divergence between duplicated genes
https://ir.soken.ac.jp/records/4441
https://ir.soken.ac.jp/records/4441387d8930-e3c3-4a3a-b1df-4659e847331a
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2014-04-21 | |||||
| タイトル | ||||||
| タイトル | The effect of gene conversion on the divergence between duplicated genes | |||||
| タイトル | ||||||
| タイトル | The effect of gene conversion on the divergence between duplicated genes | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
TESHIMA, Kosuke M.
× TESHIMA, Kosuke M.× INNAN, Hideki |
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| 著者別名 |
印南 , 秀樹
× 印南 , 秀樹 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Nonindependent evolution of duplicated genes is called concerted evolution. In this article, we study the evolutionary process of duplicated regions that involves concerted evolution. The model incorporates mutation and gene conversion: the former increases d, the divergence between two duplicated regions, while the latter decreases d. It is demonstrated that the process consists of three phases. Phase I is the time until d reaches its equilibrium value, d0. In phase II d fluctuates around d0, and d increases again in phase III. Our simulation results demonstrate that the length of concerted evolution (i.e., phase II) is highly variable, while the lengths of the other two phases are relatively constant. It is also demonstrated that the length of phase II approximately follows an exponential distribution with mean τ, which is a function of many parameters including gene conversion rate and the length of gene conversion tract. On the basis of these findings, we obtain the probability distribution of the level of divergence between a pair of duplicated regions as a function of time, mutation rate, and τ. Finally, we discuss potential problems in genomic data analysis of duplicated genes when it is based on the molecular clock but concerted evolution is common. | |||||
| 書誌情報 |
Genetics en : Genetics 巻 166, 号 3, p. 1553-1560, 発行日 2004-03-01 |
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| 出版者 | ||||||
| 出版者 | The Genetics Society of America | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0016-6731 | |||||
| 権利 | ||||||
| 権利情報 | © 2004 by The Genetics Society of America | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.genetics.org/content/genetics/166/3/1553.full.pdf | |||||
| 関連名称 | The Genetics Society of America | |||||
