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Statistical Tests of the Coalescent Model Based on the Haplotype Frequency Distribution and the Number of Segregating Sites
https://ir.soken.ac.jp/records/4451
https://ir.soken.ac.jp/records/44511ad50d97-3d98-4ceb-91b5-cd51f1b32b20
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2014-04-22 | |||||
タイトル | ||||||
タイトル | Statistical Tests of the Coalescent Model Based on the Haplotype Frequency Distribution and the Number of Segregating Sites | |||||
タイトル | ||||||
タイトル | Statistical Tests of the Coalescent Model Based on the Haplotype Frequency Distribution and the Number of Segregating Sites | |||||
言語 | en | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
INNAN, Hideki
× INNAN, Hideki× et, al. |
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著者別名 |
印南, 秀樹
× 印南, 秀樹 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Several tests of neutral evolution employ the observed number of segregating sites and properties of the haplotype frequency distribution as summary statistics and use simulations to obtain rejection probabilities. Here we develop a “haplotype configuration test” of neutrality (HCT) based on the full haplotype frequency distribution. To enable exact computation of rejection probabilities for small samples, we derive a recursion under the standard coalescent model for the joint distribution of the haplotype frequencies and the number of segregating sites. For larger samples, we consider simulation-based approaches. The utility of the HCT is demonstrated in simulations of alternative models and in application to data from Drosophila melanogaster. | |||||
書誌情報 |
Genetics en : Genetics 巻 169, 号 3, 発行日 2005-03-01 |
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出版者 | ||||||
出版者 | The Genetics Society of America | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0016-6731 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1534/genetics.104.031955 | |||||
関連名称 | 10.1534/genetics.104.032219 | |||||
権利 | ||||||
権利情報 | © The Genetics Society of America |