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  1. 010 学術雑誌論文
  2. 印南, 秀樹 / INNAN, Hideki
  1. 010 学術雑誌論文
  2. 颯田, 葉子 / SATTA, Yoko
  1. 010 学術雑誌論文
  2. 宅野, 将平 / TAKUNO, Shohei

Preservation of a Pseudogene by Gene Conversion and Diversifying Selection

https://ir.soken.ac.jp/records/4475
https://ir.soken.ac.jp/records/4475
efd03b44-a08e-4a77-b891-b40815191c7a
Item type 学術雑誌論文 / Journal Article(1)
公開日 2014-05-08
タイトル
タイトル Preservation of a Pseudogene by Gene Conversion and Diversifying Selection
タイトル
タイトル Preservation of a Pseudogene by Gene Conversion and Diversifying Selection
言語 en
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 TAKUNO, Shohei

× TAKUNO, Shohei

TAKUNO, Shohei

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NISHIO, Takeshi

× NISHIO, Takeshi

NISHIO, Takeshi

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SATTA, Yoko

× SATTA, Yoko

SATTA, Yoko

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INNAN, Hideki

× INNAN, Hideki

INNAN, Hideki

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著者別名 印南, 秀樹

× 印南, 秀樹

印南, 秀樹

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抄録
内容記述タイプ Abstract
内容記述 Interlocus gene conversion is considered a crucial mechanism for generating novel combinations of polymorphisms in duplicated genes. The importance of gene conversion between duplicated genes has been recognized in the major histocompatibility complex and self-incompatibility genes, which are likely subject to diversifying selection. To theoretically understand the potential role of gene conversion in such situations, forward simulations are performed in various two-locus models. The results show that gene conversion could significantly increase the number of haplotypes when diversifying selection works on both loci. We find that the tract length of gene conversion is an important factor to determine the efficacy of gene conversion: shorter tract lengths can more effectively generate novel haplotypes given the gene conversion rate per site is the same. Similar results are also obtained when one of the duplicated genes is assumed to be a pseudogene. It is suggested that a duplicated gene, even after being silenced, will contribute to increasing the variability in the other locus through gene conversion. Consequently, the fixation probability and longevity of duplicated genes increase under the presence of gene conversion. On the basis of these findings, we propose a new scenario for the preservation of a duplicated gene: when the original donor gene is under diversifying selection, a duplicated copy can be preserved by gene conversion even after it is pseudogenized.
書誌情報 Genetics
en : Genetics

巻 180, 号 1, p. 517-531, 発行日 2008-09
出版者
出版者 The Genetics Society of America
ISSN
収録物識別子タイプ ISSN
収録物識別子 0016-6731
DOI
識別子タイプ DOI
関連識別子 https://doi.org/10.1534/genetics.108.091918
関連名称 10.1534/genetics.108.091918
権利
権利情報 © 2008 by The Genetics Society of America
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