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On the Estimation of the Insertion Time of LTR Retrotransposable Elements
https://ir.soken.ac.jp/records/4489
https://ir.soken.ac.jp/records/4489483e40aa-03ee-4a0c-8242-cc3de17d7e83
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2014-05-09 | |||||
タイトル | ||||||
タイトル | On the Estimation of the Insertion Time of LTR Retrotransposable Elements | |||||
タイトル | ||||||
タイトル | On the Estimation of the Insertion Time of LTR Retrotransposable Elements | |||||
言語 | en | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
KIJIMA, T.E.
× KIJIMA, T.E.× INNAN, Hideki |
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著者別名 |
印南, 秀樹
× 印南, 秀樹 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | It has been proposed that the insertion time of a long terminal repeat (LTR) retrotransposon can be estimated by the divergence between the two LTRs at the both ends because their sequences were identical at the insertion event. This method is based on the assumption that the two LTRs accumulate point mutations independently; therefore, the divergence reflects the time since the insertion event. However, if gene conversion occurs between LTRs, the nucleotide divergence will be much smaller than expected with the assumption of the independent accumulation of point mutations. To examine this assumption, we investigated the extent of gene conversion between LTRs by applying a comparative genomic approach to primates (humans and rhesus macaques) and rodents (mice and rats). We found that gene conversion plays a significant role in the molecular evolution of LTRs in primates and rodents, but the extent is quite different. In rodents, most LTRs are subject to extensive gene conversion that reduces the divergence, so that the divergence-based method results in a serious underestimation of the insertion time. In primates, this effect is limited to a small proportion of LTRs. The most likely explanation of the difference involves the minimum length of the interacting sequence (minimal efficient processing segment [MEPS]) for interlocus gene conversion. An empirical estimate of MEPS in human is 300–500 bp, which exceeds the length of most of the analyzed LTRs. In contrast, MEPS for mice should be much smaller. Thus, MEPS can be an important factor to determine the susceptibility of LTRs to gene conversion, although there are many other factors involved. It is concluded that the divergence method to estimate the insertion time should be applied with special caution because at least some LTRs undergo gene conversion. | |||||
書誌情報 |
Molecular Biology and Evolution en : Molecular Biology and Evolution 巻 27, 号 4, p. 896-904, 発行日 2010 |
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出版者 | ||||||
出版者 | Oxford University Press | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0737-4038 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1093/molbev/msp295 | |||||
関連名称 | 10.1093/molbev/msp295 | |||||
権利 | ||||||
権利情報 | © The Author 2009. |