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  1. 010 学術雑誌論文
  2. 印南, 秀樹 / INNAN, Hideki

FancJ/Brip1 helicase protects against genomic losses and gains in vertebrate cells

https://ir.soken.ac.jp/records/4496
https://ir.soken.ac.jp/records/4496
3e72f5ce-d239-4a2c-b7a1-2cf859bc2d73
Item type 学術雑誌論文 / Journal Article(1)
公開日 2014-05-12
タイトル
タイトル FancJ/Brip1 helicase protects against genomic losses and gains in vertebrate cells
タイトル
タイトル FancJ/Brip1 helicase protects against genomic losses and gains in vertebrate cells
言語 en
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 KITAO, Hiroyuki

× KITAO, Hiroyuki

KITAO, Hiroyuki

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INNAN, Hideki

× INNAN, Hideki

INNAN, Hideki

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et, al.

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et, al.

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著者別名 印南, 秀樹

× 印南, 秀樹

印南, 秀樹

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抄録
内容記述タイプ Abstract
内容記述 Defects in the FANCJ/BRIP1 helicase gene are associated with genome instability disorders such as familial breast cancer or Fanconi anemia (FA). Although FANCJ has an in vitro activity to resolve G-quadruplex (G4) structures, and FANCJ ortholog in C. elegans prevents G4-associated deletions during replication, how FANCJ loss affects genome integrity in higher organisms remains unclear. Here, we report that FANCJ, but not other FA genes FANCD2 or FANCC, protected against large-scale genomic deletion that occurred frequently at the rearranged immunoglobulin heavy chain (IgH) locus in chicken DT40 cell line, suggesting that FancJ protects the genome independently of the FA ubiquitination pathway. In a more unbiased approach using array-comparative genomic hybridization, we identified de novo deletions as well as amplifications in fancj cells kept in culture for 2 months. A cluster of G4 sequence motifs was found near the breakpoint of one amplified region, but G4 sequence motifs were not detected at the breakpoints of two deleted regions. These results collectively suggest that, unlike in C. elegans, actions of vertebrate FANCJ to promote genome stability may not be limited to protection against the G4-mediated gene deletions.
書誌情報 Genes to Cells
en : Genes to Cells

巻 16, 号 6, p. 714-727, 発行日 2011-06
出版者
出版者 Wiley
ISSN
収録物識別子タイプ ISSN
収録物識別子 1356-9597
DOI
識別子タイプ DOI
関連識別子 https://doi.org/10.1111/j.1365-2443.2011.01523.x
関連名称 10.1111/j.1365-2443.2011.01523.x
権利
権利情報 © 2011 The Authors.
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