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The Coalescent with Selection on Copy Number Variants
https://ir.soken.ac.jp/records/4501
https://ir.soken.ac.jp/records/4501e4ba5f26-ec8a-4b06-9c7e-ac626f3714c2
| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2014-05-13 | |||||||||
| タイトル | ||||||||||
| タイトル | The Coalescent with Selection on Copy Number Variants | |||||||||
| タイトル | ||||||||||
| タイトル | The Coalescent with Selection on Copy Number Variants | |||||||||
| 言語 | en | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | journal article | |||||||||
| アクセス権 | ||||||||||
| アクセス権 | metadata only access | |||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||||||
| 著者 |
TESHIMA, Kosuke M.
× TESHIMA, Kosuke M.
× INNAN, Hideki
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| 著者別名 |
印南, 秀樹
× 印南, 秀樹
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| 抄録 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | We develop a coalescent-based simulation tool to generate patterns of single nucleotide polymorphisms (SNPs) in a wide region encompassing both the original and duplicated genes. Selection on the new duplicated copy and interlocus gene conversion between the two copies are incorporated. This simulation enables us to explore how selection on duplicated copies affects the pattern of SNPs. The fixation of an advantageous duplicated copy causes a strong reduction in polymorphism not only in the duplicated copy but also in its flanking regions, which is a typical signature of a selective sweep by positive selection. After fixation, polymorphism gradually increases by accumulating neutral mutations and eventually reaches the equilibrium value if there is no gene conversion. When gene conversion is active, the number of SNPs in the duplicated copy quickly increases by transferring SNPs from the original copy; therefore, the time when we can recognize the signature of selection is decreased. Because this effect of gene conversion is restricted only to the duplicated region, more power to detect selection is expected if a flanking region to the duplicated copy is used. | |||||||||
| 書誌情報 |
Genetics en : Genetics 巻 190, 号 3, p. 1077-1086, 発行日 2012-03-01 |
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| 出版者 | ||||||||||
| 出版者 | The Genetics Society of America | |||||||||
| ISSN | ||||||||||
| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 0016-6731 | |||||||||
| DOI | ||||||||||
| 識別子タイプ | DOI | |||||||||
| 関連識別子 | https://doi.org/10.1534/genetics.111.135343 | |||||||||
| 関連名称 | 10.1534/genetics.111.135343 | |||||||||
| 権利 | ||||||||||
| 権利情報 | © 2012 by The Genetics Society of America | |||||||||
