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  1. 010 学術雑誌論文
  2. 印南, 秀樹 / INNAN, Hideki
  1. 010 学術雑誌論文
  2. 宅野, 将平 / TAKUNO, Shohei

Population Genomics in Bacteria: A Case Study of Staphylococcus aureus

https://ir.soken.ac.jp/records/4507
https://ir.soken.ac.jp/records/4507
b4620900-aa28-403d-a3da-96b20d8a04e9
Item type 学術雑誌論文 / Journal Article(1)
公開日 2014-05-14
タイトル
タイトル Population Genomics in Bacteria: A Case Study of Staphylococcus aureus
タイトル
言語 en
タイトル Population Genomics in Bacteria: A Case Study of Staphylococcus aureus
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 TAKUNO, Shohei

× TAKUNO, Shohei

WEKO 768

TAKUNO, Shohei

Search repository
INNAN, Hideki

× INNAN, Hideki

WEKO 342

INNAN, Hideki

Search repository
et, al.

× et, al.

WEKO 3119

et, al.

Search repository
著者別名 印南, 秀樹

× 印南, 秀樹

WEKO 341
NRID 1000090444140
e-Rad 90444140

印南, 秀樹

Search repository
抄録
内容記述タイプ Abstract
内容記述 We analyzed the genome-wide pattern of single nucleotide polymorphisms (SNPs) in a sample with 12 strains of Staphylococcus aureus. Population structure of S. aureus seems to be complex, and the 12 strains were divided into five groups, named A, B, C, D, and E. We conducted a detailed analysis of the topologies of gene genealogies across the genomes and observed a high rate and frequency of tree-shape switching, indicating extensive homologous recombination. Most of the detected recombination occurred in the ancestral population of A, B, and C, whereas there are a number of small regions that exhibit evidence for homologous recombination with a distinct related species. As such regions would contain a number of novel mutations, it is suggested that homologous recombination would play a crucial role to maintain genetic variation within species. In the A-B-C ancestral population, we found multiple lines of evidence that the coalescent pattern is very similar to what is expected in a panmictic population, suggesting that this population is suitable to apply the standard population genetic theories. Our analysis showed that homologous recombination caused a dramatic decay in linkage disequilibrium (LD) and there is almost no LD between SNPs with distance more than 10 kb. Coalescent simulations demonstrated that a high rate of homologous recombination—a relative rate of 0.6 to the mutation rate with an average tract length of about 10 kb—is required to produce patterns similar to those observed in the S. aureus genomes. Our results call for more research into the evolutionary role of homologous recombination in bacterial populations.
書誌情報 Molecular Biology and Evolution
en : Molecular Biology and Evolution

巻 29, 号 2, p. 797-809, 発行日 2012
出版者
出版者 Oxford University Press
ISSN
収録物識別子タイプ ISSN
収録物識別子 07374038
DOI
識別子タイプ DOI
関連識別子 https://doi.org/10.1093/molbev/msr249
関連名称 10.1093/molbev/msr249
権利
権利情報 © The Author 2011.
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