| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2014-06-05 |
| タイトル |
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タイトル |
Lowly Expressed Genes in Arabidopsis thaliana Bear the Signature of Possible Pseudogenization by Promoter Degradation |
| タイトル |
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タイトル |
Lowly Expressed Genes in Arabidopsis thaliana Bear the Signature of Possible Pseudogenization by Promoter Degradation |
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言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
metadata only access |
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アクセス権URI |
http://purl.org/coar/access_right/c_14cb |
| 著者 |
YANG, Liang
TAKUNO, Shohei
WATERS, Elizabeth R.
GAUT, Brandon S.
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| 著者別名 |
宅野, 将平
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Pseudogenes are defined as nonfunctional DNA sequences with homology to functional protein-coding genes, and they typically contain nonfunctional mutations within the presumptive coding region. In theory, pseudogenes can also be caused by mutations in upstream regulatory regions, appearing as open reading frames with attenuated expression. In this study, we identified 1,939 annotated protein-coding genes with little evidence of expression in Arabidopsis thaliana and characterized their molecular evolutionary characteristics. On average, this set of genes was shorter than expressed genes and evolved with a 2-fold higher rate of nonsynonymous substitutions. The divergence of upstream sequences, based on ortholog comparisons to A. lyrata, was also higher than expressed genes, suggesting that these lowly expressed genes could be examples of pseudogenization by promoter disablement, often due to transposable element insertion. We complemented our empirical study by extending the models of Force et al. (Force A, Lynch M, Pickett FB, Amores A, Yan YL, Postlethwait J. 1999. Preservation of duplicate genes by complementary, degenerative mutations. Genetics 151:1531–1545.) to derive the probability of promoter disablements after gene duplication. |
| 書誌情報 |
Molecular Biology and Evolution
en : Molecular Biology and Evolution
巻 28,
号 3,
p. 1193-1203,
発行日 2011-11
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| 出版者 |
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出版者 |
Oxford University Press |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0737-4038 |
| DOI |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1093/molbev/msq298 |
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関連名称 |
10.1093/molbev/msq298 |
| 権利 |
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権利情報 |
© The Author 2010. |
