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Body-Methylated Genes in Arabidopsis thaliana Are Functionally Important and Evolve Slowly
https://ir.soken.ac.jp/records/4621
https://ir.soken.ac.jp/records/46218b76485b-e38c-41c4-9552-aeb97c21dc0a
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2014-06-06 | |||||
| タイトル | ||||||
| タイトル | Body-Methylated Genes in Arabidopsis thaliana Are Functionally Important and Evolve Slowly | |||||
| タイトル | ||||||
| タイトル | Body-Methylated Genes in Arabidopsis thaliana Are Functionally Important and Evolve Slowly | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
TAKUNO, Shohei
× TAKUNO, Shohei× GAUT, Brandon S. |
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| 著者別名 |
宅野, 将平
× 宅野, 将平 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | DNA methylation of coding regions, known as gene body methylation, is conserved across eukaryotic lineages. The function of body methylation is not known, but it may either prevent aberrant expression from intragenic promoters or enhance the accuracy of splicing. Given these putative functions, we hypothesized that body-methylated genes would be both longer and more functionally important than unmethylated genes. To test these hypotheses, we reanalyzed single-base resolution bisulfite sequence data from Arabidopsis thaliana to differentiate body-methylated genes from unmethylated genes using a probabilistic approach. Contrasting genic characteristics between the two groups, we found that body-methylated genes tend to be longer and to be more functionally important, as measured by phenotypic effects of insertional mutants and by gene expression, than unmethylated genes. We also found that methylated genes evolve more slowly than unmethylated genes, despite the potential for increased mutation rates in methylated CpG dinucleotides. We propose that slower rates in body-methylated genes are a function of higher selective constraint, lower nucleosome occupancy, and a lower proportion of CpG dinucleotides. | |||||
| 書誌情報 |
Molecular Biology and Evolution en : Molecular Biology and Evolution 巻 29, 号 1, p. 219-227, 発行日 2012 |
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| 出版者 | ||||||
| 出版者 | Oxford University Press | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0737-4038 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1093/molbev/msr188 | |||||
| 関連名称 | 10.1093/molbev/msr188 | |||||
| 権利 | ||||||
| 権利情報 | © The Author 2011. | |||||
