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  1. 010 学術雑誌論文
  2. 宅野, 将平 / TAKUNO, Shohei

Body-Methylated Genes in Arabidopsis thaliana Are Functionally Important and Evolve Slowly

https://ir.soken.ac.jp/records/4621
https://ir.soken.ac.jp/records/4621
8b76485b-e38c-41c4-9552-aeb97c21dc0a
Item type 学術雑誌論文 / Journal Article(1)
公開日 2014-06-06
タイトル
タイトル Body-Methylated Genes in Arabidopsis thaliana Are Functionally Important and Evolve Slowly
タイトル
タイトル Body-Methylated Genes in Arabidopsis thaliana Are Functionally Important and Evolve Slowly
言語 en
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 TAKUNO, Shohei

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TAKUNO, Shohei

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GAUT, Brandon S.

× GAUT, Brandon S.

GAUT, Brandon S.

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著者別名 宅野, 将平

× 宅野, 将平

宅野, 将平

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抄録
内容記述タイプ Abstract
内容記述 DNA methylation of coding regions, known as gene body methylation, is conserved across eukaryotic lineages. The function of body methylation is not known, but it may either prevent aberrant expression from intragenic promoters or enhance the accuracy of splicing. Given these putative functions, we hypothesized that body-methylated genes would be both longer and more functionally important than unmethylated genes. To test these hypotheses, we reanalyzed single-base resolution bisulfite sequence data from Arabidopsis thaliana to differentiate body-methylated genes from unmethylated genes using a probabilistic approach. Contrasting genic characteristics between the two groups, we found that body-methylated genes tend to be longer and to be more functionally important, as measured by phenotypic effects of insertional mutants and by gene expression, than unmethylated genes. We also found that methylated genes evolve more slowly than unmethylated genes, despite the potential for increased mutation rates in methylated CpG dinucleotides. We propose that slower rates in body-methylated genes are a function of higher selective constraint, lower nucleosome occupancy, and a lower proportion of CpG dinucleotides.
書誌情報 Molecular Biology and Evolution
en : Molecular Biology and Evolution

巻 29, 号 1, p. 219-227, 発行日 2012
出版者
出版者 Oxford University Press
ISSN
収録物識別子タイプ ISSN
収録物識別子 0737-4038
DOI
識別子タイプ DOI
関連識別子 https://doi.org/10.1093/molbev/msr188
関連名称 10.1093/molbev/msr188
権利
権利情報 © The Author 2011.
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