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Heterotypy in the N-Terminal Region of Growth/Differentiation Factor 5 (GDF5) Mature Protein during Teleost Evolution
https://ir.soken.ac.jp/records/4695
https://ir.soken.ac.jp/records/469538287ae4-336b-4fbd-a6f6-0772e34a4bc2
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2014-06-25 | |||||
| タイトル | ||||||
| タイトル | Heterotypy in the N-Terminal Region of Growth/Differentiation Factor 5 (GDF5) Mature Protein during Teleost Evolution | |||||
| タイトル | ||||||
| タイトル | Heterotypy in the N-Terminal Region of Growth/Differentiation Factor 5 (GDF5) Mature Protein during Teleost Evolution | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
FUJIMURA, Koji
× FUJIMURA, Koji× TERAI, Yohey× et, al. |
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| 著者別名 |
寺井, 洋平
× 寺井, 洋平 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Heterotypy is now recognized as a generative force in the formation of new proteins through modification of existing proteins. We report that heterotypy in the N-terminal region of the mature growth/differentiation factor 5 (GDF5) protein occurred during evolution of teleosts. N-terminal length variation of GDF5 was found among teleost interfamilies and interorders but not within teleost families or among tetrapods. We further show that increase of proline and glutamine to the N-terminal region of mature GDF5 occurred in Eurypterygii, the higher lineage of teleosts. Because the basic amino acids, believed to control diffusion, are conserved in this region across all species examined, we suggest that the N-terminal elongation of the mature GDF5 protein during evolution has altered the protein diffusion in Eurypterygii, leading to high concentrations of the protein in the joint of the pharyngeal skeleton, the location of cartilage formation during development. | |||||
| 書誌情報 |
Molecular Biology and Evolution en : Molecular Biology and Evolution 巻 25, 号 5, p. 797-800, 発行日 2008 |
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| 出版者 | ||||||
| 出版者 | Oxford University Press | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 07374038 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1093/molbev/msn041 | |||||
| 関連名称 | 10.1093/molbev/msn041 | |||||
| 権利 | ||||||
| 権利情報 | © The Author 2008 | |||||
