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  1. 010 学術雑誌論文
  2. 大田, 竜也 / OTA, Tatsuya

Genome complexity in the coelacanth is reflected in its adaptive immune system.

https://ir.soken.ac.jp/records/5424
https://ir.soken.ac.jp/records/5424
35a21fab-5c5a-48db-9ad1-6703deb19eef
Item type 学術雑誌論文 / Journal Article(1)
公開日 2017-02-23
タイトル
タイトル Genome complexity in the coelacanth is reflected in its adaptive immune system.
タイトル
言語 en
タイトル Genome complexity in the coelacanth is reflected in its adaptive immune system.
言語
言語 eng
キーワード
主題Scheme Other
主題 Coelacanth
キーワード
主題Scheme Other
主題 adaptive immunity
キーワード
主題Scheme Other
主題 immune receptor
キーワード
主題Scheme Other
主題 immunoglobulin
キーワード
主題Scheme Other
主題 T-cell receptor
キーワード
主題Scheme Other
主題 variable region
キーワード
主題Scheme Other
主題 V(D)J rearrangement
キーワード
主題Scheme Other
主題 cytokine
キーワード
主題Scheme Other
主題 cluster of differentiation
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 SAHA, Nil Ratan

× SAHA, Nil Ratan

WEKO 6221

SAHA, Nil Ratan

Search repository
OTA, Tatsuya

× OTA, Tatsuya

WEKO 6222

OTA, Tatsuya

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LITMAN, Gary W

× LITMAN, Gary W

WEKO 6223

LITMAN, Gary W

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HANSEN, John

× HANSEN, John

WEKO 6224

HANSEN, John

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PARRA, Zuly

× PARRA, Zuly

WEKO 6225

PARRA, Zuly

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HSU, Ellen

× HSU, Ellen

WEKO 6226

HSU, Ellen

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BUONOCORE, Francesco

× BUONOCORE, Francesco

WEKO 6227

BUONOCORE, Francesco

Search repository
CANAPA, Adriana

× CANAPA, Adriana

WEKO 6228

CANAPA, Adriana

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CHENG, Jan-Fang

× CHENG, Jan-Fang

WEKO 6229

CHENG, Jan-Fang

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AMEMIYA, Chris T

× AMEMIYA, Chris T

WEKO 2499

AMEMIYA, Chris T

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著者別名 SAHA, Nil Ratan

× SAHA, Nil Ratan

WEKO 6890

SAHA, Nil Ratan

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OTA, Tatsuya

× OTA, Tatsuya

WEKO 6891

OTA, Tatsuya

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LITMAN, Gary W

× LITMAN, Gary W

WEKO 6892

LITMAN, Gary W

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HANSEN, John

× HANSEN, John

WEKO 6893

HANSEN, John

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PARRA, Zuly

× PARRA, Zuly

WEKO 6894

PARRA, Zuly

Search repository
HSU, Ellen

× HSU, Ellen

WEKO 6895

HSU, Ellen

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BUONOCORE, Francesco

× BUONOCORE, Francesco

WEKO 6896

BUONOCORE, Francesco

Search repository
CANAPA, Adriana

× CANAPA, Adriana

WEKO 6897

CANAPA, Adriana

Search repository
CHENG, Jan-Fang

× CHENG, Jan-Fang

WEKO 6898

CHENG, Jan-Fang

Search repository
AMEMIYA, Chris T

× AMEMIYA, Chris T

WEKO 6899

AMEMIYA, Chris T

Search repository
著者注記
Tatsuya, Ota : Department of Evolutionary Studies of Biosystems, The Graduate University for Advanced Studies *(Associate Professor)
抄録
内容記述タイプ Abstract
内容記述 We have analyzed the available genome and transcriptome resources from the coelacanth in order to characterize genes involved in adaptive immunity. Two highly distinctive IgW-encoding loci have been identified that exhibit a unique genomic organization, including a multiplicity of tandemly repeated constant region exons. The overall organization of the IgW loci precludes typical heavy chain class switching. A locus encoding IgM could not be identified either computationally or by using several different experimental strategies. Four distinct sets of genes encoding Ig light chains were identified. This includes a variant sigma-type Ig light chain previously identified only in cartilaginous fishes and which is now provisionally denoted sigma-2. Genes encoding α/β and γ/δ T-cell receptors, and CD3, CD4, and CD8 co-receptors also were characterized. Ig heavy chain variable region genes and TCR components are interspersed within the TCR α/δ locus; this organization previously was reported only in tetrapods and raises questions regarding evolution and functional cooption of genes encoding variable regions. The composition, organization and syntenic conservation of the major histocompatibility complex locus have been characterized. We also identified large numbers of genes encoding cytokines and their receptors, and other genes associated with adaptive immunity. In terms of sequence identity and organization, the adaptive immune genes of the coelacanth more closely resemble orthologous genes in tetrapods than those in teleost fishes, consistent with current phylogenomic interpretations. Overall, the work reported described herein highlights the complexity inherent in the coelacanth genome and provides a rich catalog of immune genes for future investigations.
論文注記
Version of record online : 24 January 2014
書誌情報 Journal of experimental zoology. Part B, Molecular and developmental evolution (Special Issue: Genome of the African Coelacanth)
en : Journal of experimental zoology. Part B, Molecular and developmental evolution (Special Issue: Genome of the African Coelacanth)

巻 322, 号 6, p. 438-463, 発行日 2014-09
雑誌情報
Publication Start Year : 2003
雑誌情報
Frequency : Eight no. a year, 2008-
出版者
出版者 Wiley-Liss / Hoboken, NJ c2003-
ISSN
収録物識別子タイプ ISSN
収録物識別子 1552-5007
Online ISSN
収録物識別子タイプ ISSN
収録物識別子 1552-5015
書誌レコードID (NCID)
収録物識別子タイプ NCID
収録物識別子 AA1210851X
PubMed番号
識別子タイプ PMID
関連識別子 24464682
PMC番号
PMC4110200
DOI
識別子タイプ DOI
関連識別子 http://dx.doi.org/10.1002/jez.b.22558
関連名称 10.1002/jez.b.22558 <Wiley Online Library>
権利
権利情報 © 2014 Wiley Periodicals, Inc
関連サイト
識別子タイプ URI
関連識別子 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4110200/
関連名称 Article <PMC Free Full Text ; Author manuscript ; available in PMC 2015 Apr 1>
関連サイト
識別子タイプ URI
関連識別子 http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1552-5015
関連名称 About Journal of Experimental Zoology Part B : Molecular and Developmental Evolution <Wiley Online Library>
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