| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2017-02-23 |
| タイトル |
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|
タイトル |
Genome complexity in the coelacanth is reflected in its adaptive immune system. |
| タイトル |
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タイトル |
Genome complexity in the coelacanth is reflected in its adaptive immune system. |
|
言語 |
en |
| 言語 |
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|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Coelacanth |
| キーワード |
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主題Scheme |
Other |
|
主題 |
adaptive immunity |
| キーワード |
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主題Scheme |
Other |
|
主題 |
immune receptor |
| キーワード |
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|
主題Scheme |
Other |
|
主題 |
immunoglobulin |
| キーワード |
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主題Scheme |
Other |
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主題 |
T-cell receptor |
| キーワード |
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|
主題Scheme |
Other |
|
主題 |
variable region |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
V(D)J rearrangement |
| キーワード |
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主題Scheme |
Other |
|
主題 |
cytokine |
| キーワード |
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主題Scheme |
Other |
|
主題 |
cluster of differentiation |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| アクセス権 |
|
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アクセス権 |
metadata only access |
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アクセス権URI |
http://purl.org/coar/access_right/c_14cb |
| 著者 |
SAHA, Nil Ratan
OTA, Tatsuya
LITMAN, Gary W
HANSEN, John
PARRA, Zuly
HSU, Ellen
BUONOCORE, Francesco
CANAPA, Adriana
CHENG, Jan-Fang
AMEMIYA, Chris T
|
| 著者別名 |
SAHA, Nil Ratan
OTA, Tatsuya
LITMAN, Gary W
HANSEN, John
PARRA, Zuly
HSU, Ellen
BUONOCORE, Francesco
CANAPA, Adriana
CHENG, Jan-Fang
AMEMIYA, Chris T
|
| 著者注記 |
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Tatsuya, Ota : Department of Evolutionary Studies of Biosystems, The Graduate University for Advanced Studies *(Associate Professor) |
| 抄録 |
|
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内容記述タイプ |
Abstract |
|
内容記述 |
We have analyzed the available genome and transcriptome resources from the coelacanth in order to characterize genes involved in adaptive immunity. Two highly distinctive IgW-encoding loci have been identified that exhibit a unique genomic organization, including a multiplicity of tandemly repeated constant region exons. The overall organization of the IgW loci precludes typical heavy chain class switching. A locus encoding IgM could not be identified either computationally or by using several different experimental strategies. Four distinct sets of genes encoding Ig light chains were identified. This includes a variant sigma-type Ig light chain previously identified only in cartilaginous fishes and which is now provisionally denoted sigma-2. Genes encoding α/β and γ/δ T-cell receptors, and CD3, CD4, and CD8 co-receptors also were characterized. Ig heavy chain variable region genes and TCR components are interspersed within the TCR α/δ locus; this organization previously was reported only in tetrapods and raises questions regarding evolution and functional cooption of genes encoding variable regions. The composition, organization and syntenic conservation of the major histocompatibility complex locus have been characterized. We also identified large numbers of genes encoding cytokines and their receptors, and other genes associated with adaptive immunity. In terms of sequence identity and organization, the adaptive immune genes of the coelacanth more closely resemble orthologous genes in tetrapods than those in teleost fishes, consistent with current phylogenomic interpretations. Overall, the work reported described herein highlights the complexity inherent in the coelacanth genome and provides a rich catalog of immune genes for future investigations. |
| 論文注記 |
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Version of record online : 24 January 2014 |
| 書誌情報 |
Journal of experimental zoology. Part B, Molecular and developmental evolution (Special Issue: Genome of the African Coelacanth)
en : Journal of experimental zoology. Part B, Molecular and developmental evolution (Special Issue: Genome of the African Coelacanth)
巻 322,
号 6,
p. 438-463,
発行日 2014-09
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| 雑誌情報 |
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Publication Start Year : 2003 |
| 雑誌情報 |
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Frequency : Eight no. a year, 2008- |
| 出版者 |
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出版者 |
Wiley-Liss / Hoboken, NJ c2003- |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1552-5007 |
| Online ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1552-5015 |
| 書誌レコードID (NCID) |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA1210851X |
| PubMed番号 |
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識別子タイプ |
PMID |
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関連識別子 |
24464682 |
| PMC番号 |
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PMC4110200 |
| DOI |
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識別子タイプ |
DOI |
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関連識別子 |
http://dx.doi.org/10.1002/jez.b.22558 |
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関連名称 |
10.1002/jez.b.22558 ＜Wiley Online Library＞ |
| 権利 |
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権利情報 |
© 2014 Wiley Periodicals, Inc |
| 関連サイト |
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識別子タイプ |
URI |
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関連識別子 |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4110200/ |
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関連名称 |
Article ＜PMC Free Full Text ; Author manuscript ; available in PMC 2015 Apr 1＞ |
| 関連サイト |
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識別子タイプ |
URI |
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関連識別子 |
http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1552-5015 |
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関連名称 |
About Journal of Experimental Zoology Part B : Molecular and Developmental Evolution ＜Wiley Online Library＞ |
