| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2017-02-23 |
| タイトル |
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タイトル |
A tetrapod-like repertoire of innate immune receptors and effectors for coelacanths. |
| タイトル |
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タイトル |
A tetrapod-like repertoire of innate immune receptors and effectors for coelacanths. |
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言語 |
en |
| 言語 |
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|
言語 |
eng |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
|
主題 |
Animals |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Carrier Proteins |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Fishes |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Immunity.Innate |
| キーワード |
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言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Multigene Family |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
|
主題 |
Phylogeny |
| キーワード |
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|
言語 |
en |
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主題Scheme |
Other |
|
主題 |
Proteins |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Receptors Pattern Recognition |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Toll-Like Receptors ＜NML MeSH Terms＞ |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| アクセス権 |
|
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アクセス権 |
metadata only access |
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アクセス権URI |
http://purl.org/coar/access_right/c_14cb |
| 著者 |
BOUDINOT, Pierre
ZOU, Jun
OTA, Tatsuya
BUONOCORE, Francesco
SCAPIGLIATI, Giuseppe
CANAPA, Adriana
CANNON, John
LITMAN, Gary
HANSEN, John D
|
| 著者別名 |
BOUDINOT, Pierre
ZOU, Jun
OTA, Tatsuya
BUONOCORE, Francesco
SCAPIGLIATI, Giuseppe
CANAPA, Adriana
CANNON, John
LITMAN, Gary
HANSEN, John D
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| 著者注記 |
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Tatsuya, Ota：Department of Evolutionary Studies of Biosystems, The Graduate University for Advanced Studies *(Associate Professor) |
| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
The recent availability of both robust transcriptome and genome resources for coelacanth (Latimeria chalumnae) has led to unique discoveries for coelacanth immunity such as the lack of IgM, a central component of adaptive immunity. This study was designed to more precisely address the origins and evolution of gene families involved in the initial recognition and response to microbial pathogens, which effect innate immunity. Several multigene families involved in innate immunity are addressed, including: Toll-like receptors (TLRs), retinoic acid inducible gene 1 (RIG1)-like receptors (RLRs), the nucleotide-binding domain and leucine-rich repeat containing proteins (NLRs), diverse immunoglobulin domain-containing proteins (DICP) and modular domain immune-type receptors (MDIRs). Our analyses also include the tripartite motif-containing proteins (TRIM), which are involved in pathogen recognition as well as the positive regulation of antiviral immunity. Finally, this study addressed some of the downstream effectors of the antimicrobial response including IL-1 family members, type I and II interferons (IFN) and IFN-stimulated effectors (ISGs). Collectively, the genes and gene families in coelacanth that effect innate immune functions share characteristics both in content, structure and arrangement with those found in tetrapods but not in teleosts. The findings support the sister group relationship of coelacanth fish with tetrapods. |
| 論文注記 |
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Version of record online : 30 JAN 2014 |
| 書誌情報 |
Journal of experimental zoology. Part B, Molecular and developmental evolution (Special Issue: Genome of the African Coelacanth)
en : Journal of experimental zoology. Part B, Molecular and developmental evolution (Special Issue: Genome of the African Coelacanth)
巻 322,
号 6,
p. 415-437,
発行日 2014-09
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| 雑誌情報 |
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Publication Start Year : 2003 |
| 雑誌情報 |
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Frequency : Eight no. a year, 2008- |
| 出版者 |
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出版者 |
Wiley-Liss / Hoboken, NJ c2003- |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1552-5007 |
| Online ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1552-5015 |
| 書誌レコードID (NCID) |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA1210851X |
| PubMed番号 |
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識別子タイプ |
PMID |
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関連識別子 |
24482296 |
| DOI |
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識別子タイプ |
DOI |
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関連識別子 |
http://dx.doi.org/10.1002/jez.b.22559 |
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関連名称 |
10.1002/jez.b.22559 ＜Wiley Online Library＞ |
| 権利 |
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権利情報 |
© 2014 Wiley Periodicals, Inc. |
| 関連サイト |
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識別子タイプ |
URI |
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関連識別子 |
http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1552-5015 |
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関連名称 |
About Journal of Experimental Zoology Part B : Molecular and Developmental Evolution ＜Wiley Online Library＞ |
