| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2017-02-23 |
| タイトル |
|
|
タイトル |
Comparative genomic analysis of the proteasome β5t subunit gene : implications for the origin and evolution of thymoproteasomes. |
| タイトル |
|
|
タイトル |
Comparative genomic analysis of the proteasome β5t subunit gene : implications for the origin and evolution of thymoproteasomes. |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Thymoproteasome |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Immunoproteasome |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
β5t subunit |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
PSMB11 |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
PSMB5 |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
metadata only access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_14cb |
| 著者 |
SUTOH, Yoichi
KONDO, Mizuho
OHTA, Yuko
OTA, Tatsuya
TOMARU, Utano
FLAJNIK, Martin F
KASAHARA, Masanori
|
| 著者別名 |
SUTOH, Yoichi
KONDO, Mizuho
OHTA, Yuko
OTA, Tatsuya
TOMARU, Utano
FLAJNIK, Martin F
KASAHARA, Masanori
|
| 著者注記 |
|
|
|
Tatsuya, Ota： Department of Evolutionary Studies of Biosystems, The Graduate University for Advanced Studies *(Associate Professor) |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
The thymoproteasome is a recently discovered, specialized form of 20S proteasomes expressed exclusively in the thymic cortex. Although the precise molecular mechanism by which the thymoproteasome exerts its function remains to be elucidated, accumulating evidence indicates that it plays a crucial role in positive selection of T cells. In the present study, we analyzed the evolution of the β5t subunit, a β-type catalytic subunit uniquely present in thymoproteasomes. The gene coding for the β5t subunit, designated PSMB11, was identified in the cartilaginous fish, the most divergent group of jawed vertebrates compared to the other jawed vertebrates, but not in jawless vertebrates or invertebrates. Interestingly, teleost fish have two copies of apparently functional PSMB11 genes, designated PSMB11a and PSMB11b, that encode β5t subunits with distinct amino acids in the S1 pocket. BLAST searches of genome databases suggest that birds such as chickens, turkey, and zebra finch lost the PSMB11 gene, and have neither thymoproteasomes nor immunoproteasomes. In mammals, reptiles, amphibians, and teleost fishes, the PSMB11 gene (the PSMB11a gene in teleost fish) is located next to the PSMB5 gene coding for the β5 subunit of the standard 20S proteasome, indicating that the PSMB11 gene arose by tandem duplication from the evolutionarily more ancient PSMB5 gene. The general absence of introns in PSMB11 and an unusual exon-intron structure of jawed vertebrate PSMB5 suggest that PSMB5 lost introns and duplicated in tandem in a common ancestor of jawed vertebrates, with PSMB5 subsequently gaining two introns and PSMB11 remaining intronless. |
| 論文注記 |
|
|
|
Published online : 7 July 2011 |
| 書誌情報 |
Immunogenetics
en : Immunogenetics
巻 64,
号 1,
p. 49-58,
発行日 2012-01
|
| 雑誌情報 |
|
|
|
Publication Start Year : 1974 |
| 雑誌情報 |
|
|
|
Frequency : Monthly |
| 出版者 |
|
|
出版者 |
Springer Berlin Heidelberg |
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0093-7711 |
| Online ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1432-1211 |
| 書誌レコードID (NCID) |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11624885 |
| PubMed番号 |
|
|
|
識別子タイプ |
PMID |
|
|
関連識別子 |
21748441 |
| PMC番号 |
|
|
|
PMC3805029 |
| DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
http://dx.doi.org/10.1007/s00251-011-0558-0 |
|
|
関連名称 |
10.1007/s00251-011-0558-0 ＜Springer Abstract＞ |
| 権利 |
|
|
権利情報 |
© Springer-Verlag 2011 |
| 関連サイト |
|
|
|
識別子タイプ |
URI |
|
|
関連識別子 |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3805029/ |
|
|
関連名称 |
Article ＜PMC FREE Full Txet : Author manuscript ; available in PMC 2013 Oct 22.＞ |
| 関連サイト |
|
|
|
識別子タイプ |
URI |
|
|
関連識別子 |
http://rd.springer.com/journal/251 |
|
|
関連名称 |
About Immunogenetics ＜Springer＞ |
