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  1. 010 学術雑誌論文
  2. 大田, 竜也 / OTA, Tatsuya

Comparative genomic analysis of the proteasome β5t subunit gene : implications for the origin and evolution of thymoproteasomes.

https://ir.soken.ac.jp/records/5435
https://ir.soken.ac.jp/records/5435
9977291a-3020-43fb-b184-75db4a9c8fd3
Item type 学術雑誌論文 / Journal Article(1)
公開日 2017-02-23
タイトル
タイトル Comparative genomic analysis of the proteasome β5t subunit gene : implications for the origin and evolution of thymoproteasomes.
タイトル
タイトル Comparative genomic analysis of the proteasome β5t subunit gene : implications for the origin and evolution of thymoproteasomes.
言語 en
言語
言語 eng
キーワード
主題Scheme Other
主題 Thymoproteasome
キーワード
主題Scheme Other
主題 Immunoproteasome
キーワード
主題Scheme Other
主題 β5t subunit
キーワード
主題Scheme Other
主題 PSMB11
キーワード
主題Scheme Other
主題 PSMB5
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 SUTOH, Yoichi

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SUTOH, Yoichi

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KONDO, Mizuho

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KONDO, Mizuho

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OHTA, Yuko

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OHTA, Yuko

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OTA, Tatsuya

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OTA, Tatsuya

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TOMARU, Utano

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TOMARU, Utano

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FLAJNIK, Martin F

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FLAJNIK, Martin F

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KASAHARA, Masanori

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KASAHARA, Masanori

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著者別名 SUTOH, Yoichi

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SUTOH, Yoichi

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KONDO, Mizuho

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KONDO, Mizuho

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OHTA, Yuko

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OHTA, Yuko

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OTA, Tatsuya

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OTA, Tatsuya

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TOMARU, Utano

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TOMARU, Utano

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FLAJNIK, Martin F

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FLAJNIK, Martin F

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KASAHARA, Masanori

× KASAHARA, Masanori

KASAHARA, Masanori

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著者注記
Tatsuya, Ota: Department of Evolutionary Studies of Biosystems, The Graduate University for Advanced Studies *(Associate Professor)
抄録
内容記述タイプ Abstract
内容記述 The thymoproteasome is a recently discovered, specialized form of 20S proteasomes expressed exclusively in the thymic cortex. Although the precise molecular mechanism by which the thymoproteasome exerts its function remains to be elucidated, accumulating evidence indicates that it plays a crucial role in positive selection of T cells. In the present study, we analyzed the evolution of the β5t subunit, a β-type catalytic subunit uniquely present in thymoproteasomes. The gene coding for the β5t subunit, designated PSMB11, was identified in the cartilaginous fish, the most divergent group of jawed vertebrates compared to the other jawed vertebrates, but not in jawless vertebrates or invertebrates. Interestingly, teleost fish have two copies of apparently functional PSMB11 genes, designated PSMB11a and PSMB11b, that encode β5t subunits with distinct amino acids in the S1 pocket. BLAST searches of genome databases suggest that birds such as chickens, turkey, and zebra finch lost the PSMB11 gene, and have neither thymoproteasomes nor immunoproteasomes. In mammals, reptiles, amphibians, and teleost fishes, the PSMB11 gene (the PSMB11a gene in teleost fish) is located next to the PSMB5 gene coding for the β5 subunit of the standard 20S proteasome, indicating that the PSMB11 gene arose by tandem duplication from the evolutionarily more ancient PSMB5 gene. The general absence of introns in PSMB11 and an unusual exon-intron structure of jawed vertebrate PSMB5 suggest that PSMB5 lost introns and duplicated in tandem in a common ancestor of jawed vertebrates, with PSMB5 subsequently gaining two introns and PSMB11 remaining intronless.
論文注記
Published online : 7 July 2011
書誌情報 Immunogenetics
en : Immunogenetics

巻 64, 号 1, p. 49-58, 発行日 2012-01
雑誌情報
Publication Start Year : 1974
雑誌情報
Frequency : Monthly
出版者
出版者 Springer Berlin Heidelberg
ISSN
収録物識別子タイプ ISSN
収録物識別子 0093-7711
Online ISSN
収録物識別子タイプ ISSN
収録物識別子 1432-1211
書誌レコードID (NCID)
収録物識別子タイプ NCID
収録物識別子 AA11624885
PubMed番号
識別子タイプ PMID
関連識別子 21748441
PMC番号
PMC3805029
DOI
識別子タイプ DOI
関連識別子 http://dx.doi.org/10.1007/s00251-011-0558-0
関連名称 10.1007/s00251-011-0558-0 <Springer Abstract>
権利
権利情報 © Springer-Verlag 2011
関連サイト
識別子タイプ URI
関連識別子 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3805029/
関連名称 Article <PMC FREE Full Txet : Author manuscript ; available in PMC 2013 Oct 22.>
関連サイト
識別子タイプ URI
関連識別子 http://rd.springer.com/journal/251
関連名称 About Immunogenetics <Springer>
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