ログイン
言語:

WEKO3

  • トップ
  • ランキング
To
lat lon distance
To

Field does not validate



インデックスリンク

インデックスツリー

メールアドレスを入力してください。

WEKO

One fine body…

WEKO

One fine body…

アイテム

  1. 010 学術雑誌論文
  2. 颯田, 葉子 / SATTA, Yoko
  1. 010 学術雑誌論文
  2. 02 学生発表論文
  3. 秋山, 辰穂 / AKIYAMA, Tokiho

An ancestral haplotype of the human PERIOD2 gene associates with reduced sensitivity to light-induced melatonin suppression.

https://ir.soken.ac.jp/records/5633
https://ir.soken.ac.jp/records/5633
f951ae41-4526-4e91-b607-3824f4c5aeac
名前 / ファイル ライセンス アクション
file.pdf 本文 / Article (3.6 MB)
license.icon
Item type 学術雑誌論文 / Journal Article(1)
公開日 2017-07-06
タイトル
タイトル An ancestral haplotype of the human PERIOD2 gene associates with reduced sensitivity to light-induced melatonin suppression.
タイトル
タイトル An ancestral haplotype of the human PERIOD2 gene associates with reduced sensitivity to light-induced melatonin suppression.
言語 en
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
著者 AKIYAMA, Tokiho

× AKIYAMA, Tokiho

AKIYAMA, Tokiho

Search repository
KATSUMURA, Takafumi

× KATSUMURA, Takafumi

KATSUMURA, Takafumi

Search repository
NAKAGOME, Shigeki

× NAKAGOME, Shigeki

NAKAGOME, Shigeki

Search repository
LEE, Sang-Il

× LEE, Sang-Il

LEE, Sang-Il

Search repository
JOH, Keiichiro

× JOH, Keiichiro

JOH, Keiichiro

Search repository
SOEJIMA, Hidenobu

× SOEJIMA, Hidenobu

SOEJIMA, Hidenobu

Search repository
FUJIMOTO, Kazuma

× FUJIMOTO, Kazuma

FUJIMOTO, Kazuma

Search repository
KIMURA, Ryosuke

× KIMURA, Ryosuke

KIMURA, Ryosuke

Search repository
ISHIDA, Hajime

× ISHIDA, Hajime

ISHIDA, Hajime

Search repository
HANIHARA, Tsunehiko

× HANIHARA, Tsunehiko

HANIHARA, Tsunehiko

Search repository
YASUKOUCHI, Akira

× YASUKOUCHI, Akira

YASUKOUCHI, Akira

Search repository
SATTA, Yoko

× SATTA, Yoko

SATTA, Yoko

Search repository
HIGUCHI, Shigekazu

× HIGUCHI, Shigekazu

HIGUCHI, Shigekazu

Search repository
OOTA, Hiroki

× OOTA, Hiroki

OOTA, Hiroki

Search repository
著者別名 AKIYAMA, Tokiho

× AKIYAMA, Tokiho

AKIYAMA, Tokiho

Search repository
KATSUMURA, Takafumi

× KATSUMURA, Takafumi

KATSUMURA, Takafumi

Search repository
NAKAGOME, Shigeki

× NAKAGOME, Shigeki

NAKAGOME, Shigeki

Search repository
LEE, Sang-Il

× LEE, Sang-Il

LEE, Sang-Il

Search repository
JOH, Keiichiro

× JOH, Keiichiro

JOH, Keiichiro

Search repository
SOEJIMA, Hidenobu

× SOEJIMA, Hidenobu

SOEJIMA, Hidenobu

Search repository
FUJIMOTO, Kazuma

× FUJIMOTO, Kazuma

FUJIMOTO, Kazuma

Search repository
KIMURA, Ryosuke

× KIMURA, Ryosuke

KIMURA, Ryosuke

Search repository
ISHIDA, Hajime

× ISHIDA, Hajime

ISHIDA, Hajime

Search repository
HANIHARA, Tsunehiko

× HANIHARA, Tsunehiko

HANIHARA, Tsunehiko

Search repository
YASUKOUCHI, Akira

× YASUKOUCHI, Akira

YASUKOUCHI, Akira

Search repository
SATTA, Yoko

× SATTA, Yoko

SATTA, Yoko

Search repository
HIGUCHI, Shigekazu

× HIGUCHI, Shigekazu

HIGUCHI, Shigekazu

Search repository
OOTA, Hiroki

× OOTA, Hiroki

OOTA, Hiroki

Search repository
著者注記
Tokiho, Akiyama : Department of Evolutionary Studies of Biosystems, SOKENDAI (The Graduate University for Advanced Studies)
著者注記
Yoko, Satta : Department of Evolutionary Studies of Biosystems, SOKENDAI (The Graduate University for Advanced Studies) *(Professor)
抄録
内容記述タイプ Abstract
内容記述 Humans show various responses to the environmental stimulus in individual levels as "physiological variations." However, it has been unclear if these are caused by genetic variations. In this study, we examined the association between the physiological variation of response to light-stimulus and genetic polymorphisms. We collected physiological data from 43 subjects, including light-induced melatonin suppression, and performed haplotype analyses on the clock genes, PER2 and PER3, exhibiting geographical differentiation of allele frequencies. Among the haplotypes of PER3, no significant difference in light sensitivity was found. However, three common haplotypes of PER2 accounted for more than 96% of the chromosomes in subjects, and 1 of those 3 had a significantly low-sensitive response to light-stimulus (P < 0.05). The homozygote of the low-sensitive PER2 haplotype showed significantly lower percentages of melatonin suppression (P < 0.05), and the heterozygotes of the haplotypes varied their ratios, indicating that the physiological variation for light-sensitivity is evidently related to the PER2 polymorphism. Compared with global haplotype frequencies, the haplotype with a low-sensitive response was more frequent in Africans than in non-Africans, and came to the root in the phylogenetic tree, suggesting that the low light-sensitive haplotype is the ancestral type, whereas the other haplotypes with high sensitivity to light are the derived types. Hence, we speculate that the high light-sensitive haplotypes have spread throughout the world after the Out-of-Africa migration of modern humans.
書誌情報 PLoS ONE
en : PLoS ONE

巻 12, 号 6, p. e0178373, 発行日 2017-06-26
雑誌情報
Publication Start Year : 2006
雑誌情報
Frequency : Monthly
雑誌情報
A Peer-Reviewed, Open Access Journal, Electronic only
出版者
出版者 Public Library of Science / San Francisco, CA
Online ISSN
収録物識別子タイプ ISSN
収録物識別子 1932-6203
PubMed番号
関連タイプ isIdenticalTo
識別子タイプ PMID
関連識別子 28650999
DOI
関連タイプ isIdenticalTo
識別子タイプ DOI
関連識別子 https://doi.org/10.1371/journal.pone.0178373
関連名称 10.1371/journal.pone.0178373 <PLoS ONE Open Access Full Text>
権利
権利情報 © 2017 Akiyama et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | http://journals.plos.org/plosone/s/licenses-and-copyright
関連サイト
識別子タイプ URI
関連識別子 https://www.ncbi.nlm.nih.gov/pmc/journals/440/
関連名称 Archive of PLoS ONE <PMC Journal List>
関連サイト
識別子タイプ URI
関連識別子 http://journals.plos.org/plosone/s/journal-information
関連名称 About PLoS ONE <Public Library of Science>
著者版フラグ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
戻る
0
views
See details
Views

Versions

Ver.1 2023-06-20 15:04:41.280605
Show All versions

Share

Mendeley Twitter Facebook Print Addthis

Cite as

エクスポート

OAI-PMH
  • OAI-PMH JPCOAR 2.0
  • OAI-PMH JPCOAR 1.0
  • OAI-PMH DublinCore
  • OAI-PMH DDI
Other Formats
  • JSON
  • BIBTEX

Confirm


Powered by WEKO3


Powered by WEKO3