| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2017-07-06 |
| タイトル |
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タイトル |
An ancestral haplotype of the human PERIOD2 gene associates with reduced sensitivity to light-induced melatonin suppression. |
| タイトル |
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タイトル |
An ancestral haplotype of the human PERIOD2 gene associates with reduced sensitivity to light-induced melatonin suppression. |
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言語 |
en |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
AKIYAMA, Tokiho
KATSUMURA, Takafumi
NAKAGOME, Shigeki
LEE, Sang-Il
JOH, Keiichiro
SOEJIMA, Hidenobu
FUJIMOTO, Kazuma
KIMURA, Ryosuke
ISHIDA, Hajime
HANIHARA, Tsunehiko
YASUKOUCHI, Akira
SATTA, Yoko
HIGUCHI, Shigekazu
OOTA, Hiroki
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| 著者別名 |
AKIYAMA, Tokiho
KATSUMURA, Takafumi
NAKAGOME, Shigeki
LEE, Sang-Il
JOH, Keiichiro
SOEJIMA, Hidenobu
FUJIMOTO, Kazuma
KIMURA, Ryosuke
ISHIDA, Hajime
HANIHARA, Tsunehiko
YASUKOUCHI, Akira
SATTA, Yoko
HIGUCHI, Shigekazu
OOTA, Hiroki
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| 著者注記 |
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Tokiho, Akiyama : Department of Evolutionary Studies of Biosystems, SOKENDAI (The Graduate University for Advanced Studies) |
| 著者注記 |
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Yoko, Satta : Department of Evolutionary Studies of Biosystems, SOKENDAI (The Graduate University for Advanced Studies) *(Professor) |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Humans show various responses to the environmental stimulus in individual levels as "physiological variations." However, it has been unclear if these are caused by genetic variations. In this study, we examined the association between the physiological variation of response to light-stimulus and genetic polymorphisms. We collected physiological data from 43 subjects, including light-induced melatonin suppression, and performed haplotype analyses on the clock genes, PER2 and PER3, exhibiting geographical differentiation of allele frequencies. Among the haplotypes of PER3, no significant difference in light sensitivity was found. However, three common haplotypes of PER2 accounted for more than 96% of the chromosomes in subjects, and 1 of those 3 had a significantly low-sensitive response to light-stimulus (P < 0.05). The homozygote of the low-sensitive PER2 haplotype showed significantly lower percentages of melatonin suppression (P < 0.05), and the heterozygotes of the haplotypes varied their ratios, indicating that the physiological variation for light-sensitivity is evidently related to the PER2 polymorphism. Compared with global haplotype frequencies, the haplotype with a low-sensitive response was more frequent in Africans than in non-Africans, and came to the root in the phylogenetic tree, suggesting that the low light-sensitive haplotype is the ancestral type, whereas the other haplotypes with high sensitivity to light are the derived types. Hence, we speculate that the high light-sensitive haplotypes have spread throughout the world after the Out-of-Africa migration of modern humans. |
| 書誌情報 |
PLoS ONE
en : PLoS ONE
巻 12,
号 6,
p. e0178373,
発行日 2017-06-26
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| 雑誌情報 |
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Publication Start Year : 2006 |
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Frequency : Monthly |
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A Peer-Reviewed, Open Access Journal, Electronic only |
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出版者 |
Public Library of Science / San Francisco, CA |
| Online ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1932-6203 |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
PMID |
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関連識別子 |
28650999 |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1371/journal.pone.0178373 |
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関連名称 |
10.1371/journal.pone.0178373 ＜PLoS ONE Open Access Full Text＞ |
| 権利 |
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権利情報 |
© 2017 Akiyama et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | http://journals.plos.org/plosone/s/licenses-and-copyright |
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識別子タイプ |
URI |
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関連識別子 |
https://www.ncbi.nlm.nih.gov/pmc/journals/440/ |
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関連名称 |
Archive of PLoS ONE ＜PMC Journal List＞ |
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識別子タイプ |
URI |
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関連識別子 |
http://journals.plos.org/plosone/s/journal-information |
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関連名称 |
About PLoS ONE ＜Public Library of Science＞ |
| 著者版フラグ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
本文 / Article (3.6 MB)
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