{"_buckets": {"deposit": "3faec319-4d61-40c2-b32e-f356d1ecf638"}, "_deposit": {"created_by": 24, "id": "5923", "owners": [24], "pid": {"revision_id": 0, "type": "depid", "value": "5923"}, "status": "published"}, "_oai": {"id": "oai:ir.soken.ac.jp:00005923", "sets": ["34"]}, "author_link": ["10745", "10746"], "item_2_creator_3": {"attribute_name": "著者名(英)", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "TAKUNO, Shohei", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "10746", "nameIdentifierScheme": "WEKO"}]}]}, "item_2_date_4": {"attribute_name": "発行日", "attribute_value_mlt": [{"subitem_date_issued_datetime": "2019-04-01", "subitem_date_issued_type": "Created"}]}, "item_2_description_13": {"attribute_name": "研究課題番号", "attribute_value_mlt": [{"subitem_description": "15K18585", "subitem_description_type": "Other"}]}, "item_2_description_14": {"attribute_name": "フォーマット", "attribute_value_mlt": [{"subitem_description": "application/pdf", "subitem_description_type": "Other"}]}, "item_2_description_16": {"attribute_name": "研究期間", "attribute_value_mlt": [{"subitem_description": "2015～2017", "subitem_description_type": "Other"}]}, "item_2_description_17": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "研究成果の概要（和文）：ゲノム進化学にエピジェネティックスを取り入れ、ゲノム-エピゲノム間の進化的インタラクションと新たな自然選択の検出を目指して研究を行った。エピゲノムのうち、DNAメチル化に着目して研究を行った。陸上植物のDNAメチル化、特に遺伝子的メチル化に焦点を当てて、解析を行った。遺伝子内メチル化は自然選択により、長期間植物種のオーソログで保存されていた。遺伝子内メチル化レベルは、トランスポゾン増加によるDNAメチル化レベルの影響を受け進化していた。さらに、遺伝子内メチル化を保護するため、そのメチル化を持つ遺伝子のDNA配列への自然選択が検出された。\n\n研究成果の概要（英文）：DNA methylation is an important epigenetic modification that affects both chromatin packing and transcription. DNA methylation occurs in three sequence contexts, that is, CG,CHG, and CHH(where H is A,C,orT) in plants. All three contexts are methylated within repetitive elements. The major role of DNA methylation within repetitive elements is to silence transcription and functions as a host defense against transposons. On the other hand, only the CG context is mainly methylated within coding regions in plants that is called gene body methylation. Gene body methylation is considered a byproduct of the process of removing heterochromatic marks within active genes; gene body methylation might not be functional. However, I found that gene body methylation was observed in a biased subset of genes, tended to be conserved between plant orthologs, and the drastic changes of gene body methylation significantly affected expression levels.　\n", "subitem_description_type": "Abstract"}]}, "item_2_description_6": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "科学研究費補助金研究成果報告書\n研究代表者：宅野将平[総合研究大学院大学・先導科学研究科・助教]", "subitem_description_type": "Other"}]}, "item_2_relation_11": {"attribute_name": "関連サイト", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "KAKEN（科学研究費補助金データベース）"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://kaken.nii.ac.jp/search/?kw=%E3%82%A8%E3%83%94%E3%82%B8%E3%82%A7%E3%83%8D%E3%83%86%E3%82%A3%E3%83%83%E3%82%AF%E4%BF%AE%E9%A3%BE%E3%81%AB%E9%96%A2%E3%82%8F%E3%82%8B%E8%87%AA%E7%84%B6%E9%81%B8%E6%8A%9E%E3%81%AE%E6%A4%9C%E5%87%BA", "subitem_relation_type_select": "URI"}}]}, "item_2_text_19": {"attribute_name": "研究分野", "attribute_value_mlt": [{"subitem_text_value": "進化エピジェネティックス"}]}, "item_2_text_20": {"attribute_name": "研究種目", "attribute_value_mlt": [{"subitem_text_value": "若手研究（B）"}]}, "item_2_text_5": {"attribute_name": "報告年度", "attribute_value_mlt": [{"subitem_text_value": "2017"}]}, "item_2_version_type_12": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "宅野, 将平"}], "nameIdentifiers": [{"nameIdentifier": "10745", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-04-10"}], "displaytype": "simple", "download_preview_message": "", "file_order": 0, "filename": "15K18585seika.pdf", "filesize": [{"value": "202.4 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_11", "mimetype": "application/pdf", "size": 202400.0, "url": {"label": "研究成果報告書", "url": "https://ir.soken.ac.jp/record/5923/files/15K18585seika.pdf"}, "version_id": "af5cea9f-bad1-4d6b-bbb8-e178dc6e9695"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "ゲノム進化", "subitem_subject_scheme": "Other"}, {"subitem_subject": "エピジェネティックス", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "research report", "resourceuri": "http://purl.org/coar/resource_type/c_18ws"}]}, "item_title": "エピジェネティック修飾に関わる自然選択の検出", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "エピジェネティック修飾に関わる自然選択の検出"}, {"subitem_title": "Natural selection for maintaining epigenetic status in plants", "subitem_title_language": "en"}]}, "item_type_id": "2", "owner": "24", "path": ["34", "339"], "permalink_uri": "https://ir.soken.ac.jp/records/5923", "pubdate": {"attribute_name": "公開日", "attribute_value": "2019-04-10"}, "publish_date": "2019-04-10", "publish_status": "0", "recid": "5923", "relation": {}, "relation_version_is_last": true, "title": ["エピジェネティック修飾に関わる自然選択の検出"], "weko_shared_id": -1}