| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2013-10-25 |
| タイトル |
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タイトル |
Genomic structure and evolution of multigene families: “Flowers” on the human genome |
| タイトル |
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タイトル |
Genomic structure and evolution of multigene families: “Flowers” on the human genome |
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言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
KIM, Hie Lim
IWASE, Mineyo
IGAWA, Takeshi
NISHIOKA, Tasuku
KANEKO, Satoko
KATSURA, Yukako
TAKAHATA, Naoyuki
SATTA, Yoko
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| 著者別名 |
尚之, 高畑
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
We report the results of an extensive investigation of genomic structures in the human genome, with a particular focus on relatively large repeats (>50 kb) in adjacent chromosomal regions. We named such structures “Flowers” because the pattern observed on dot plots resembles a flower. We detected a total of 291 Flowers in the human genome. They were predominantly located in euchromatic regions. Flowers are gene-rich compared to the average gene density of the genome. Genes involved in systems receiving environmental information, such as immunity and detoxification, were overrepresented in Flowers. Within a Flower, the mean number of duplication units was approximately four. The maximum and minimum identities between homologs in a Flower showed different distributions; the maximum identity was often concentrated to 100% identity, while the minimum identity was evenly distributed in the range of 78% to 100%. Using a gene conversion detection test, we found frequent and/or recent gene conversion events within the tested Flowers. Interestingly, many of those converted regions contained protein-coding genes. Computer simulation studies suggest that one role of such frequent gene conversions is the elongation of the life span of gene families in a Flower by the resurrection of pseudogenes. |
| 書誌情報 |
International Journal of Evolutionary Biology
en : International Journal of Evolutionary Biology
号 Article ID 917678,
p. 11,
発行日 2012
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| 出版者 |
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出版者 |
Hindawi Publishing Corporation |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
2090-052X |
| DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
http://dx.doi.org/10.1155/2012/917678 |
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関連名称 |
10.1155/2012/917678 |
| 権利 |
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権利情報 |
© 2012 Hie Lim Kim et al. |
| 関連サイト |
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識別子タイプ |
URI |
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関連識別子 |
http://www.hindawi.com/journals/apm/apc/ |
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関連名称 |
Copyright |
| フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
| 著者版フラグ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
![917678[1].pdf](/static/images/icon/icon_16_pdf.jpg){kind=icon}
917678[1] (1.8 MB)
