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Genomic structure and evolution of multigene families: “Flowers” on the human genome
https://ir.soken.ac.jp/records/4039
https://ir.soken.ac.jp/records/4039f5ec683f-938c-48a6-96c4-026632725040
名前 / ファイル | ライセンス | アクション |
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-10-25 | |||||
タイトル | ||||||
タイトル | Genomic structure and evolution of multigene families: “Flowers” on the human genome | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Genomic structure and evolution of multigene families: “Flowers” on the human genome | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
KIM, Hie Lim
× KIM, Hie Lim× IWASE, Mineyo× IGAWA, Takeshi× NISHIOKA, Tasuku× KANEKO, Satoko× KATSURA, Yukako× TAKAHATA, Naoyuki× SATTA, Yoko |
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著者別名 |
尚之, 高畑
× 尚之, 高畑 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We report the results of an extensive investigation of genomic structures in the human genome, with a particular focus on relatively large repeats (>50 kb) in adjacent chromosomal regions. We named such structures “Flowers” because the pattern observed on dot plots resembles a flower. We detected a total of 291 Flowers in the human genome. They were predominantly located in euchromatic regions. Flowers are gene-rich compared to the average gene density of the genome. Genes involved in systems receiving environmental information, such as immunity and detoxification, were overrepresented in Flowers. Within a Flower, the mean number of duplication units was approximately four. The maximum and minimum identities between homologs in a Flower showed different distributions; the maximum identity was often concentrated to 100% identity, while the minimum identity was evenly distributed in the range of 78% to 100%. Using a gene conversion detection test, we found frequent and/or recent gene conversion events within the tested Flowers. Interestingly, many of those converted regions contained protein-coding genes. Computer simulation studies suggest that one role of such frequent gene conversions is the elongation of the life span of gene families in a Flower by the resurrection of pseudogenes. | |||||
書誌情報 |
International Journal of Evolutionary Biology en : International Journal of Evolutionary Biology 号 Article ID 917678, p. 11, 発行日 2012 |
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出版者 | ||||||
出版者 | Hindawi Publishing Corporation | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2090-052X | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | http://dx.doi.org/10.1155/2012/917678 | |||||
関連名称 | 10.1155/2012/917678 | |||||
権利 | ||||||
権利情報 | © 2012 Hie Lim Kim et al. | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | http://www.hindawi.com/journals/apm/apc/ | |||||
関連名称 | Copyright | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |