| Item type |
学位論文 / Thesis or Dissertation(1) |
| 公開日 |
2010-02-22 |
| タイトル |
|
|
タイトル |
Development of GABAergic neurons in mouse superior colliculus |
| タイトル |
|
|
タイトル |
Development of GABAergic neurons in mouse superior colliculus |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_46ec |
|
資源タイプ |
thesis |
| 著者名 |
常川, 直子
|
| フリガナ |
ツナカワ, ナオコ
|
| 著者 |
TSUNAKAWA, Naoko
|
| 学位授与機関 |
|
|
|
学位授与機関名 |
総合研究大学院大学 |
| 学位名 |
|
|
学位名 |
博士（理学） |
| 学位記番号 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
総研大甲第704号 |
| 研究科 |
|
|
値 |
生命科学研究科 |
| 専攻 |
|
|
値 |
20 生理科学専攻 |
| 学位授与年月日 |
|
|
学位授与年月日 |
2003-03-24 |
| 学位授与年度 |
|
|
値 |
2002 |
| 要旨 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
γ-Aminobutyric acid (GABA) is a major inhibitory neurotransmitter in the mammalian central nervous system (CNS). The levels of GABA and its synthetic enzyme glutamate decarboxylase (GAD) in superior colliculus (SC) are high. They investigated the early development of SC, including early GABAergic neurons, using GAD67-GFP knock-in (GAD67+-/- and GFP+/-) mice to mark GABAergic neurons and observe their migration.<br /> It was revealed by observation of cells labeled with BrdU that neurons in mouse SC generated from E 11.5 to E 15.5 with a peak at E 13.5. The generation of GABAergic neurons had a peak at E 12.5 and they migrated and spread throughout SC by E 16.5. By BrdU and DsRed2 labeling, the inside-out cell migration pattern was not evident in SC compared with that in neocortex. They observed the shape of cell bodies, arrangements, nestin-immunoreactivity of SC cells, and time-lapse of living GABAergic neurons. These observations indicated radial migration of GABAergic neurons and generation in the ventricular zone. They made cuts at an early stage that intercept either or both radial and tangential cell migration in SC, and the result of this experiment also supported our conclusion. It was also noticeable that the surface of the SC was covered with GABAergic fibers at an early stage, when GABAergic cells were not yet differentiated in SC. |
| 所蔵 |
|
|
値 |
有 |
| フォーマット |
|
|
内容記述タイプ |
Other |
|
内容記述 |
application/pdf |
要旨・審査要旨 / Abstract, Screening Result (184.6 kB)
