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  1. 020 学位論文
  2. 生命科学研究科
  3. 20 生理科学専攻

Development of GABAergic neurons in mouse superior colliculus

https://ir.soken.ac.jp/records/1135
https://ir.soken.ac.jp/records/1135
8c5715a3-95f8-4292-9fd7-b24fbfb4be5e
名前 / ファイル ライセンス アクション
甲704_要旨.pdf 要旨・審査要旨 / Abstract, Screening Result (184.6 kB)
甲704_本文.pdf 本文 (2.5 MB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2010-02-22
タイトル
タイトル Development of GABAergic neurons in mouse superior colliculus
タイトル
言語 en
タイトル Development of GABAergic neurons in mouse superior colliculus
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_46ec
資源タイプ thesis
著者名 常川, 直子

× 常川, 直子

WEKO 9420

常川, 直子

Search repository
フリガナ ツナカワ, ナオコ

× ツナカワ, ナオコ

WEKO 9421

ツナカワ, ナオコ

Search repository
著者 TSUNAKAWA, Naoko

× TSUNAKAWA, Naoko

WEKO 9422

en TSUNAKAWA, Naoko

Search repository
学位授与機関
学位授与機関名 総合研究大学院大学
学位名
学位名 博士(理学)
学位記番号
内容記述タイプ Other
内容記述 総研大甲第704号
研究科
値 生命科学研究科
専攻
値 20 生理科学専攻
学位授与年月日
学位授与年月日 2003-03-24
学位授与年度
2002
要旨
内容記述タイプ Other
内容記述 γ-Aminobutyric acid (GABA) is a major inhibitory neurotransmitter in the mammalian central nervous system (CNS). The levels of GABA and its synthetic enzyme glutamate decarboxylase (GAD) in superior colliculus (SC) are high. They investigated the early development of SC, including early GABAergic neurons, using GAD67-GFP knock-in (GAD67+-/- and GFP+/-) mice to mark GABAergic neurons and observe their migration.<br /> It was revealed by observation of cells labeled with BrdU that neurons in mouse SC generated from E 11.5 to E 15.5 with a peak at E 13.5. The generation of GABAergic neurons had a peak at E 12.5 and they migrated and spread throughout SC by E 16.5. By BrdU and DsRed2 labeling, the inside-out cell migration pattern was not evident in SC compared with that in neocortex. They observed the shape of cell bodies, arrangements, nestin-immunoreactivity of SC cells, and time-lapse of living GABAergic neurons. These observations indicated radial migration of GABAergic neurons and generation in the ventricular zone. They made cuts at an early stage that intercept either or both radial and tangential cell migration in SC, and the result of this experiment also supported our conclusion. It was also noticeable that the surface of the SC was covered with GABAergic fibers at an early stage, when GABAergic cells were not yet differentiated in SC.
所蔵
値 有
フォーマット
内容記述タイプ Other
内容記述 application/pdf
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