| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2012-12-12 |
| タイトル |
|
|
タイトル |
PERK eIF2α kinase regulates neonatal growth by controlling the expression of circulating insulin-like growth factor-I derived from the liver |
| タイトル |
|
|
タイトル |
PERK eIF2α kinase regulates neonatal growth by controlling the expression of circulating insulin-like growth factor-I derived from the liver |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
LI, Yulin
IIDA, Kaori
O’NEIL, Jeff
ZHANG, Peichuan
LI, Sheng’ai
FRANK, Ami
GABAI, Aryn
ZAMBITO, Frank
LIANG, Shun-Hsin
ROSEN, Clifford J
CAVENER, Douglas R
|
| 著者別名 |
飯田, 香穂里
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Humans afflicted with the Wolcott-Rallison syndrome and mice deficient for PERK (pancreatic endoplasmic reticulum eIF2α kinase) show severe postnatal growth retardation. In mice, growth retardation in Perk−/− mutants is manifested within the first few days of neonatal development. Growth parameters of Perk−/− mice, including comparison of body weight to length and organ weights, are consistent with proportional dwarfism. Tibia growth plates exhibited a reduction in proliferative and hypertrophic chondrocytes underlying the longitudinal growth retardation. Neonatal Perk−/− deficient mice show a 75% reduction in liver IGF-I mRNA and serum IGF-I within the first week, whereas the expression of IGF-I mRNA in most other tissues is normal. Injections of IGF-I partially reversed the growth retardation of the Perk−/− mice, whereas GH had no effect. Transgenic rescue of PERK activity in the insulin- secreting β-cells of the Perk−/− mice reversed the juvenile but not the neonatal growth retardation. We provide evidence that circulating IGF-I is derived from neonatal liver but is independent of GH at this stage. We propose that PERK is required to regulate the expression of IGF-I in the liver during the neonatal period, when IGF-I expression is GH-independent, and that the lack of this regulation results in severe neonatal growth retardation. |
| 書誌情報 |
Endocrinology
en : Endocrinology
巻 144,
号 8,
p. 3505-3513,
発行日 2003-04-11
|
| 出版者 |
|
|
出版者 |
The Endocrine Society |
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
00137227 |
| DOI |
|
|
関連タイプ |
isIdenticalTo |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1210/en.2003-0236 |
|
|
関連名称 |
10.1210/en.2003-0236 |
| 権利 |
|
|
権利情報 |
© 2003 by The Endocrine Society |
| 関連サイト |
|
|
|
識別子タイプ |
URI |
|
|
関連識別子 |
http://www.biomedcentral.com/about/license |
|
|
関連名称 |
Copyright |
| フォーマット |
|
|
内容記述タイプ |
Other |
|
内容記述 |
application/pdf |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
本文 (316.2 kB)
.png)
