{"_buckets": {"deposit": "8036b6d8-7a1c-43e7-913d-0142386500c1"}, "_deposit": {"created_by": 21, "id": "3289", "owners": [21], "pid": {"revision_id": 0, "type": "depid", "value": "3289"}, "status": "published"}, "_oai": {"id": "oai:ir.soken.ac.jp:00003289", "sets": ["273"]}, "author_link": ["733", "732", "730", "373", "374", "727", "729", "720", "723", "731", "728", "722"], "item_10001_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2003-04-11", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "8", "bibliographicPageEnd": "3513", "bibliographicPageStart": "3505", "bibliographicVolumeNumber": "144", "bibliographic_titles": [{"bibliographic_title": "Endocrinology "}, {"bibliographic_title": "Endocrinology ", "bibliographic_titleLang": "en"}]}]}, "item_10001_creator_3": {"attribute_name": "著者別名", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "飯田, 香穂里"}], "nameIdentifiers": [{"nameIdentifier": "373", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "1000010589667", "nameIdentifierScheme": "NRID", "nameIdentifierURI": " "}, {"nameIdentifier": "10589667", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=10589667"}]}]}, "item_10001_description_19": {"attribute_name": "フォーマット", "attribute_value_mlt": [{"subitem_description": "application/pdf", "subitem_description_type": "Other"}]}, "item_10001_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Humans afflicted with the Wolcott-Rallison syndrome and mice deficient for PERK (pancreatic endoplasmic reticulum eIF2α kinase) show severe postnatal growth retardation. In mice, growth retardation in Perk−/− mutants is manifested within the first few days of neonatal development. Growth parameters of Perk−/− mice, including comparison of body weight to length and organ weights, are consistent with proportional dwarfism. Tibia growth plates exhibited a reduction in proliferative and hypertrophic chondrocytes underlying the longitudinal growth retardation. Neonatal Perk−/− deficient mice show a 75% reduction in liver IGF-I mRNA and serum IGF-I within the first week, whereas the expression of IGF-I mRNA in most other tissues is normal. Injections of IGF-I partially reversed the growth retardation of the Perk−/− mice, whereas GH had no effect. Transgenic rescue of PERK activity in the insulin- secreting β-cells of the Perk−/− mice reversed the juvenile but not the neonatal growth retardation. We provide evidence that circulating IGF-I is derived from neonatal liver but is independent of GH at this stage. We propose that PERK is required to regulate the expression of IGF-I in the liver during the neonatal period, when IGF-I expression is GH-independent, and that the lack of this regulation results in severe neonatal growth retardation.", "subitem_description_type": "Abstract"}]}, "item_10001_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "The Endocrine Society"}]}, "item_10001_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.1210/en.2003-0236"}], "subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1210/en.2003-0236 ", "subitem_relation_type_select": "DOI"}}]}, "item_10001_relation_17": {"attribute_name": "関連サイト", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "Copyright"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://www.biomedcentral.com/about/license", "subitem_relation_type_select": "URI"}}]}, "item_10001_rights_15": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "© 2003 by The Endocrine Society"}]}, "item_10001_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00137227 ", "subitem_source_identifier_type": "ISSN"}]}, "item_10001_version_type_20": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "LI, Yulin"}], "nameIdentifiers": [{"nameIdentifier": "720", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "IIDA, Kaori"}], "nameIdentifiers": [{"nameIdentifier": "374", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "O’NEIL, Jeff"}], "nameIdentifiers": [{"nameIdentifier": "727", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "ZHANG, Peichuan"}], "nameIdentifiers": [{"nameIdentifier": "728", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "LI, Sheng’ai "}], "nameIdentifiers": [{"nameIdentifier": "729", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "FRANK, Ami"}], "nameIdentifiers": [{"nameIdentifier": "722", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "GABAI, Aryn "}], "nameIdentifiers": [{"nameIdentifier": "730", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "ZAMBITO, Frank "}], "nameIdentifiers": [{"nameIdentifier": "731", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "LIANG, Shun-Hsin "}], "nameIdentifiers": [{"nameIdentifier": "732", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "ROSEN, Clifford J"}], "nameIdentifiers": [{"nameIdentifier": "733", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "CAVENER, Douglas R"}], "nameIdentifiers": [{"nameIdentifier": "723", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2014-03-11"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "3505.full.pdf", "filesize": [{"value": "316.2 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_11", "mimetype": "application/pdf", "size": 316200.0, "url": {"label": "本文", "url": "https://ir.soken.ac.jp/record/3289/files/3505.full.pdf"}, "version_id": "62a02e95-89ba-4e52-a572-6beedabd8662"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "PERK eIF2α kinase regulates neonatal growth by controlling the expression of circulating insulin-like growth factor-I derived from the liver", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "PERK eIF2α kinase regulates neonatal growth by controlling the expression of circulating insulin-like growth factor-I derived from the liver"}, {"subitem_title": "PERK eIF2α kinase regulates neonatal growth by controlling the expression of circulating insulin-like growth factor-I derived from the liver", "subitem_title_language": "en"}]}, "item_type_id": "10001", "owner": "21", "path": ["131", "273"], "permalink_uri": "https://ir.soken.ac.jp/records/3289", "pubdate": {"attribute_name": "公開日", "attribute_value": "2012-12-12"}, "publish_date": "2012-12-12", "publish_status": "0", "recid": "3289", "relation": {}, "relation_version_is_last": true, "title": ["PERK eIF2α kinase regulates neonatal growth by controlling the expression of circulating insulin-like growth factor-I derived from the liver"], "weko_shared_id": 21}