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  1. 010 学術雑誌論文
  2. 印南, 秀樹 / INNAN, Hideki
  1. 010 学術雑誌論文
  2. 宅野, 将平 / TAKUNO, Shohei

The Power of QTL Mapping with RILs

https://ir.soken.ac.jp/records/3304
https://ir.soken.ac.jp/records/3304
1da0ad28-7e8e-4509-b59f-43af33416b0a
名前 / ファイル ライセンス アクション
journal.pone.0046545[1].pdf journal.pone.0046545[1] (654.4 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2012-12-18
タイトル
タイトル The Power of QTL Mapping with RILs
タイトル
言語 en
タイトル The Power of QTL Mapping with RILs
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
著者 TAKUNO, Shohei

× TAKUNO, Shohei

WEKO 768

TAKUNO, Shohei

Search repository
TERAUCHI, Ryohei

× TERAUCHI, Ryohei

WEKO 769

TERAUCHI, Ryohei

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INNAN, Hideki

× INNAN, Hideki

WEKO 342

INNAN, Hideki

Search repository
著者別名 印南, 秀樹

× 印南, 秀樹

WEKO 341
NRID 1000090444140
e-Rad 90444140

印南, 秀樹

Search repository
抄録
内容記述タイプ Abstract
内容記述 QTL (quantitative trait loci) mapping is commonly used to identify genetic regions responsible to important phenotype variation. A common strategy of QTL mapping is to use recombinant inbred lines (RILs), which are usually established by several generations of inbreeding of an F1 population (usually up to F6 or F7 populations). As this inbreeding process involves a large amount of labor, we are particularly interested in the effect of the number of inbreeding generations on the power of QTL mapping; a part of the labor could be saved if a smaller number of inbreeding provides sufficient power. By using simulations, we investigated the performance of QTL mapping with recombinant inbred lines (RILs). As expected, we found that the power of F4 population could be almost comparable to that of F6 and F7 populations. A potential problem in using F4 population is that a large proportion of RILs are heterozygotes. We here introduced a new method to partly relax this problem. The performance of this method was verified by simulations with a wide range of parameters including the size of the segregation population, recombination rate, genome size and the density of markers. We found our method works better than the commonly used standard method especially when there are a number of heterozygous markers. Our results imply that in most cases, QTL mapping does not necessarily require RILs at F6 or F7 generations; rather, F4 (or even F3) populations would be almost as useful as F6 or F7 populations. Because the cost to establish a number of RILs for many generations is enormous, this finding will cause a reduction in the cost of QTL mapping, thereby accelerating gene mapping in many species.
書誌情報 PLoS ONE
en : PLoS ONE

巻 7, 号 10, 発行日 2012-10-09
出版者
出版者 Public Library of Science
ISSN
収録物識別子タイプ ISSN
収録物識別子 19326203
DOI
関連タイプ isIdenticalTo
識別子タイプ DOI
関連識別子 https://doi.org/10.1371/journal.pone.0046545
関連名称 10.1371/journal.pone.0046545
権利
権利情報 © Takuno et al.
関連サイト
識別子タイプ URI
関連識別子 http://www.plos.org/about/open-access/license/
関連名称 Copyright
フォーマット
内容記述タイプ Other
内容記述 application/pdf
著者版フラグ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
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