WEKO3
アイテム
Recombination or mutational hot spots in human mtDNA?
https://ir.soken.ac.jp/records/3648
https://ir.soken.ac.jp/records/364880040a61-9f5a-40d2-af87-b082583602a2
| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2013-06-27 | |||||||||
| タイトル | ||||||||||
| タイトル | Recombination or mutational hot spots in human mtDNA? | |||||||||
| タイトル | ||||||||||
| タイトル | Recombination or mutational hot spots in human mtDNA? | |||||||||
| 言語 | en | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | journal article | |||||||||
| アクセス権 | ||||||||||
| アクセス権 | metadata only access | |||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||||||
| 著者 |
INNAN, Hideki
× INNAN, Hideki
× NORDBORG, Magnus
|
|||||||||
| 著者別名 |
印南, 秀樹
× 印南, 秀樹
|
|||||||||
| 抄録 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | Awadalla, Eyre-Walker, and Maynard Smith (1999)<$REFLINK> recently argued that there might be recombination in human mitochondrial DNA (mtDNA). Their claim was based on their observation of decaying linkage disequilibrium (LD) as a function of physical distance. Their study was much criticized, and follow-up studies have failed to find any evidence for recombination. We argue that the criticisms levied, even if correct, could not possibly explain the findings of Awadalla, Eyre-Walker, and Maynard Smith (1999)<$REFLINK> . Nonetheless, the test proposed by Awadalla, Eyre-Walker, and Maynard Smith (1999<$REFLINK> ) is not robust because recombination is not the only explanation for decay of LD. We show that such a pattern can be caused by mutational hot spots as well. However, a closer look at the data suggests that the pattern observed was not caused by mutational hot spots but rather by chance. Thus, there appears to be no evidence for recombination in the mtDNA polymorphism data. In conclusion, we discuss the possibility of detecting recombination in mtDNA and the implications of its existence. | |||||||||
| 書誌情報 |
Molecular Biology and Evolution en : Molecular Biology and Evolution 巻 19, 号 7, p. 1122-1127, 発行日 2002 |
|||||||||
| 出版者 | ||||||||||
| 出版者 | Oxford University Press | |||||||||
| ISSN | ||||||||||
| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 07374038 | |||||||||
| PubMed番号 | ||||||||||
| 識別子タイプ | PMID | |||||||||
| 関連識別子 | 12082131 | |||||||||
| DOI | ||||||||||
| 識別子タイプ | DOI | |||||||||
| 関連識別子 | https://doi.org/10.1093/oxfordjournals.molbev.a004170 | |||||||||
| 関連名称 | 10.1093/oxfordjournals.molbev.a004170 | |||||||||
