| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2013-07-03 |
| タイトル |
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タイトル |
Evolutionary Relationships of Major Histocompatibility Complex Class I Genes in Simian Primates |
| タイトル |
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タイトル |
Evolutionary Relationships of Major Histocompatibility Complex Class I Genes in Simian Primates |
|
言語 |
en |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
metadata only access |
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アクセス権URI |
http://purl.org/coar/access_right/c_14cb |
| 著者 |
SAWAI, Hiromi
KAWAMOTO, Yoshi
TAKAHATA, Naoyuki
SATTA, Yoko
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| 著者別名 |
尚之, 高畑
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
New World monkeys (NWMs) occupy a critical phylogenetic position in elucidating the evolutionary process of major histocompatibility complex (MHC) class I genes in primates. From three subfamilies of Aotinae, Cebinae, and Atelinae, the 5′-flanking regions of 18 class I genes are obtained and phylogenetically examined in terms of Alu/LINE insertion elements as well as the nucleotide substitutions. Two pairs of genes from Aotinae and Atelinae are clearly orthologous to human leukocyte antigen (HLA) -E and -F genes. Of the remaining 14 genes, 8 belong to the distinct group B, together with HLA-B and -C, to the exclusion of all other HLA class I genes. These NWM genes are classified into four groups, designated as NWM-B1, -B2, -B3, and -B4. Of these, NWM-B2 is orthologous to HLA-B/C. Also, orthologous relationships of NWM-B1, -B2, and -B3 exist among different families of Cebidae and Atelidae, which is in sharp contrast to the genus-specific gene organization within the subfamily Callitrichinae. The other six genes belong to the distinct group G. However, a clade of these NWM genes is almost equally related to HLA-A, -J, -G, and -K, and there is no evidence for their orthologous relationships to HLA-G. It is argued that class I genes in simian primates duplicated extensively in their common ancestral lineage and that subsequent evolution in descendant species has been facilitated mainly by independent loss of genes. |
| 書誌情報 |
Genetics
en : Genetics
巻 166,
号 4,
p. 1897-1907,
発行日 2004-04
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| 出版者 |
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出版者 |
The Genetics Society of America |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
00166731 |
| PubMed番号 |
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識別子タイプ |
PMID |
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関連識別子 |
15126407 |
| DOI |
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識別子タイプ |
DOI |
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|
関連識別子 |
https://doi.org/10.1534/genetics.166.4.1897 |
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関連名称 |
10.1534/genetics.166.4.1897 |
| 権利 |
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権利情報 |
© 2004 by The Genetics Society of America |
