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Evolutionary Relationships of Major Histocompatibility Complex Class I Genes in Simian Primates
https://ir.soken.ac.jp/records/3703
https://ir.soken.ac.jp/records/3703f8e1fb29-178c-4713-9185-ce56b554c106
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-07-03 | |||||
| タイトル | ||||||
| タイトル | Evolutionary Relationships of Major Histocompatibility Complex Class I Genes in Simian Primates | |||||
| タイトル | ||||||
| タイトル | Evolutionary Relationships of Major Histocompatibility Complex Class I Genes in Simian Primates | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
SAWAI, Hiromi
× SAWAI, Hiromi× KAWAMOTO, Yoshi× TAKAHATA, Naoyuki× SATTA, Yoko |
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| 著者別名 |
尚之, 高畑
× 尚之, 高畑 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | New World monkeys (NWMs) occupy a critical phylogenetic position in elucidating the evolutionary process of major histocompatibility complex (MHC) class I genes in primates. From three subfamilies of Aotinae, Cebinae, and Atelinae, the 5′-flanking regions of 18 class I genes are obtained and phylogenetically examined in terms of Alu/LINE insertion elements as well as the nucleotide substitutions. Two pairs of genes from Aotinae and Atelinae are clearly orthologous to human leukocyte antigen (HLA) -E and -F genes. Of the remaining 14 genes, 8 belong to the distinct group B, together with HLA-B and -C, to the exclusion of all other HLA class I genes. These NWM genes are classified into four groups, designated as NWM-B1, -B2, -B3, and -B4. Of these, NWM-B2 is orthologous to HLA-B/C. Also, orthologous relationships of NWM-B1, -B2, and -B3 exist among different families of Cebidae and Atelidae, which is in sharp contrast to the genus-specific gene organization within the subfamily Callitrichinae. The other six genes belong to the distinct group G. However, a clade of these NWM genes is almost equally related to HLA-A, -J, -G, and -K, and there is no evidence for their orthologous relationships to HLA-G. It is argued that class I genes in simian primates duplicated extensively in their common ancestral lineage and that subsequent evolution in descendant species has been facilitated mainly by independent loss of genes. | |||||
| 書誌情報 |
Genetics en : Genetics 巻 166, 号 4, p. 1897-1907, 発行日 2004-04 |
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| 出版者 | ||||||
| 出版者 | The Genetics Society of America | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 00166731 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 15126407 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1534/genetics.166.4.1897 | |||||
| 関連名称 | 10.1534/genetics.166.4.1897 | |||||
| 権利 | ||||||
| 権利情報 | © 2004 by The Genetics Society of America | |||||
