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  1. 010 学術雑誌論文
  2. 高畑, 尚之 / TAKAHATA, Naoyuki

Genealogy of neutral genes and spreading of selected mutations in a geographically structured population

https://ir.soken.ac.jp/records/3705
https://ir.soken.ac.jp/records/3705
71896125-ac3a-4cfa-8292-d76f645f2659
Item type 学術雑誌論文 / Journal Article(1)
公開日 2013-07-03
タイトル
タイトル Genealogy of neutral genes and spreading of selected mutations in a geographically structured population
タイトル
言語 en
タイトル Genealogy of neutral genes and spreading of selected mutations in a geographically structured population
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 TAKAHATA, Naoyuki

× TAKAHATA, Naoyuki

WEKO 778

TAKAHATA, Naoyuki

Search repository
著者別名 尚之, 高畑

× 尚之, 高畑

WEKO 1577
NRID 1000030124217
e-Rad 30124217

尚之, 高畑

Search repository
抄録
内容記述タイプ Abstract
内容記述 In a geographically structured population, the interplay among gene migration, genetic drift and natural selection raises intriguing evolutionary problems, but the rigorous mathematical treatment is often very difficult. Therefore several approximate formulas were developed concerning the coalescence process of neutral genes and the fixation process of selected mutations in an island model, and their accuracy was examined by computer simulation. When migration is limited, the coalescence (or divergence) time for sampled neutral genes can be described by the convolution of exponential functions, as in a panmictic population, but it is determined mainly by migration rate and the number of demes from which the sample is taken. This time can be much longer than that in a panmictic population with the same number of breeding individuals. For a selected mutation, the spreading over the entire population was formulated as a birth and death process, in which the fixation probability within a deme plays a key role. With limited amounts of migration, even advantageous mutations take a large number of generations to spread. Furthermore, it is likely that these mutations which are temporarily fixed in some demes may be swamped out again by non-mutant immigrants from other demes unless selection is strong enough. These results are potentially useful for testing quantitatively various hypotheses that have been proposed for the origin of modern human populations.
書誌情報 Genetics
en : Genetics

巻 129, 号 2, p. 585-595, 発行日 1991
出版者
出版者 The Genetics Society of America
ISSN
収録物識別子タイプ ISSN
収録物識別子 00166731
PubMed番号
関連タイプ isIdenticalTo
識別子タイプ PMID
関連識別子 1743494
権利
権利情報 © 1991 by The Genetics Society of America
著者版フラグ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
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