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  1. 010 学術雑誌論文
  2. 颯田, 葉子 / SATTA, Yoko
  1. 010 学術雑誌論文
  2. 高畑, 尚之 / TAKAHATA, Naoyuki

Alu-mediated inactivation of the human CMP-N-acetylneuraminic acid hydroxylase gene

https://ir.soken.ac.jp/records/3761
https://ir.soken.ac.jp/records/3761
c519537e-a785-4bf2-8367-c166a8b332e4
Item type 学術雑誌論文 / Journal Article(1)
公開日 2013-07-08
タイトル
タイトル Alu-mediated inactivation of the human CMP-N-acetylneuraminic acid hydroxylase gene
タイトル
言語 en
タイトル Alu-mediated inactivation of the human CMP-N-acetylneuraminic acid hydroxylase gene
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 HAYAKAWA, Toshiyuki

× HAYAKAWA, Toshiyuki

WEKO 1563

HAYAKAWA, Toshiyuki

Search repository
SATTA, Yoko

× SATTA, Yoko

WEKO 357

SATTA, Yoko

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GAGNEUX, Pascal

× GAGNEUX, Pascal

WEKO 1674

GAGNEUX, Pascal

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TAKAHATA, Naoyuki

× TAKAHATA, Naoyuki

WEKO 778

TAKAHATA, Naoyuki

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VARKI, Ajit

× VARKI, Ajit

WEKO 1600

VARKI, Ajit

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著者別名 尚之, 高畑

× 尚之, 高畑

WEKO 1577
NRID 1000030124217
e-Rad 30124217

尚之, 高畑

Search repository
抄録
内容記述タイプ Abstract
内容記述 Inactivation of the CMP-N-acetylneuraminic acid hydroxylase gene has provided an example of human-specific genomic mutation that results in a widespread biochemical difference between human and nonhuman primates. We have found that, although a region containing a 92-bp exon and an AluSq element in the hydroxylase gene is intact in all nonhuman primates examined, the same region in the human genome is replaced by an AluY element that was disseminated at least one million years ago. We propose a mechanistic model for this Alu-mediated replacement event, which deleted the 92-bp exon and thus inactivated the human hydroxylase gene. It is suggested that Alu elements have played potentially important roles in genotypic and phenotypic evolution in the hominid lineage.
書誌情報 Proceedings of the National Academy of Sciences of the United States of America
en : Proceedings of the National Academy of Sciences of the United States of America

巻 98, 号 20, p. 11399-11404, 発行日 2001-09-25
出版者
出版者 National Academy of Sciences
ISSN
収録物識別子タイプ ISSN
収録物識別子 10916490
PubMed番号
識別子タイプ PMID
関連識別子 11562455
DOI
識別子タイプ DOI
関連識別子 https://doi.org/10.1073/pnas.191268198
関連名称 10.1073/pnas.191268198
権利
権利情報 © 2001, The National Academy of Sciences
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