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  1. 010 学術雑誌論文
  2. 高畑, 尚之 / TAKAHATA, Naoyuki

Selective constraint in protein polymorphism: Study of the effectively neutral mutation model by using an improved pseudosampling method

https://ir.soken.ac.jp/records/3769
https://ir.soken.ac.jp/records/3769
af9cb2d1-c871-4198-bd77-8579be97189a
Item type 学術雑誌論文 / Journal Article(1)
公開日 2013-07-09
タイトル
タイトル Selective constraint in protein polymorphism: Study of the effectively neutral mutation model by using an improved pseudosampling method
タイトル
タイトル Selective constraint in protein polymorphism: Study of the effectively neutral mutation model by using an improved pseudosampling method
言語 en
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 KIMURA, Motoo

× KIMURA, Motoo

KIMURA, Motoo

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TAKAHATA, Naoyuki

× TAKAHATA, Naoyuki

TAKAHATA, Naoyuki

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著者別名 尚之, 高畑

× 尚之, 高畑

尚之, 高畑

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抄録
内容記述タイプ Abstract
内容記述 To investigate the pattern of allelic distribution in enzyme polymorphism, with special reference to the relationship between the mean (H̄) and the variance (V(H)) of heterozygosity, we used the model of effectively neutral mutations involving multiple alleles in which selective disadvantage of mutant alleles follows a Γ distribution. A simulation method was developed that enables us to study efficiently the process of random drift in a multiallelic genetic system and that saves a great deal of computer time. It is an improved version of the pseudosampling-variable (PSV) method previously used to simulate random drift in a diallelic system. This method will be useful for simulating many models of population genetics that involve behavior of multiple alleles in a finite population. By using this method, it was shown that, as compared with the model of strictly neutral mutations, the present model gives the reduction of both H̄ and V(H) and an excess of rare variant alleles. The results were discussed in the light of recent observations on protein polymorphism with special reference to the functional constraint of proteins involved.
書誌情報 Proceedings of the National Academy of Sciences of the United States of America
en : Proceedings of the National Academy of Sciences of the United States of America

巻 80, 号 4, p. 1048-1052, 発行日 1983
出版者
出版者 National Academy of Sciences
ISSN
収録物識別子タイプ ISSN
収録物識別子 10916490
PubMed番号
識別子タイプ PMID
関連識別子 6573657
DOI
識別子タイプ DOI
関連識別子 https://doi.org/10.1073/pnas.80.4.1048
関連名称 10.1073/pnas.80.4.1048
権利
権利情報 © National Academy of Sciences
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