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Selective constraint in protein polymorphism: Study of the effectively neutral mutation model by using an improved pseudosampling method
https://ir.soken.ac.jp/records/3769
https://ir.soken.ac.jp/records/3769af9cb2d1-c871-4198-bd77-8579be97189a
| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2013-07-09 | |||||||||
| タイトル | ||||||||||
| タイトル | Selective constraint in protein polymorphism: Study of the effectively neutral mutation model by using an improved pseudosampling method | |||||||||
| タイトル | ||||||||||
| タイトル | Selective constraint in protein polymorphism: Study of the effectively neutral mutation model by using an improved pseudosampling method | |||||||||
| 言語 | en | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | journal article | |||||||||
| アクセス権 | ||||||||||
| アクセス権 | metadata only access | |||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||||||
| 著者 |
KIMURA, Motoo
× KIMURA, Motoo
× TAKAHATA, Naoyuki
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| 著者別名 |
尚之, 高畑
× 尚之, 高畑
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| 抄録 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | To investigate the pattern of allelic distribution in enzyme polymorphism, with special reference to the relationship between the mean (H̄) and the variance (V(H)) of heterozygosity, we used the model of effectively neutral mutations involving multiple alleles in which selective disadvantage of mutant alleles follows a Γ distribution. A simulation method was developed that enables us to study efficiently the process of random drift in a multiallelic genetic system and that saves a great deal of computer time. It is an improved version of the pseudosampling-variable (PSV) method previously used to simulate random drift in a diallelic system. This method will be useful for simulating many models of population genetics that involve behavior of multiple alleles in a finite population. By using this method, it was shown that, as compared with the model of strictly neutral mutations, the present model gives the reduction of both H̄ and V(H) and an excess of rare variant alleles. The results were discussed in the light of recent observations on protein polymorphism with special reference to the functional constraint of proteins involved. | |||||||||
| 書誌情報 |
Proceedings of the National Academy of Sciences of the United States of America en : Proceedings of the National Academy of Sciences of the United States of America 巻 80, 号 4, p. 1048-1052, 発行日 1983 |
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| 出版者 | ||||||||||
| 出版者 | National Academy of Sciences | |||||||||
| ISSN | ||||||||||
| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 10916490 | |||||||||
| PubMed番号 | ||||||||||
| 識別子タイプ | PMID | |||||||||
| 関連識別子 | 6573657 | |||||||||
| DOI | ||||||||||
| 識別子タイプ | DOI | |||||||||
| 関連識別子 | https://doi.org/10.1073/pnas.80.4.1048 | |||||||||
| 関連名称 | 10.1073/pnas.80.4.1048 | |||||||||
| 権利 | ||||||||||
| 権利情報 | © National Academy of Sciences | |||||||||
