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Bloom helicase and DNA topoisomerase III alpha are involved in the dissolution of sister chromatids
https://ir.soken.ac.jp/records/3970
https://ir.soken.ac.jp/records/39701ddcb5d4-e46d-410a-8cd5-b28fa7367bca
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
6299.full (690.4 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-09-19 | |||||
| タイトル | ||||||
| タイトル | Bloom helicase and DNA topoisomerase III alpha are involved in the dissolution of sister chromatids | |||||
| タイトル | ||||||
| タイトル | Bloom helicase and DNA topoisomerase III alpha are involved in the dissolution of sister chromatids | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
SEKI, Masayuki
× SEKI, Masayuki× TANABE, Hideyuki× et, al. |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Bloom's syndrome (BS) is an autosomal disorder characterized by predisposition to a wide variety of cancers. The gene product whose mutation leads to BS is the RecQ family helicase BLM, which forms a complex with DNA topoisomerase IIIα (Top3α). However, the physiological relevance of the interaction between BLM and Top3α within the cell remains unclear. We show here that Top3α depletion causes accumulation of cells in G2 phase, enlargement of nuclei, and chromosome gaps and breaks that occur at the same position in sister chromatids. The transition from metaphase to anaphase is also inhibited. All of these phenomena except cell lethality are suppressed by BLM gene disruption. Taken together with the biochemical properties of BLM and Top3α, these data indicate that BLM and Top3α execute the dissolution of sister chromatids. | |||||
| 書誌情報 |
Molecular and Cellular Biology en : Molecular and Cellular Biology 巻 26, 号 16, p. 6299-6307, 発行日 2006-08 |
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| 出版者 | ||||||
| 出版者 | American Society for Microbiology | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0270-7306 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | http://doi.org/10.1128/MCB.00702-06 | |||||
| 関連名称 | 10.1128/MCB.00702-06 | |||||
| 権利 | ||||||
| 権利情報 | © 2013 by American Society for Microbiology | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://journals.asm.org/site/misc/ASM_Author_Statement.xhtml | |||||
| 関連名称 | Copyright | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
