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  1. 010 学術雑誌論文
  2. 田辺, 秀之 / TANABE, Hideyuki

A novel assay system for anti-human immunodeficiency virus type 1 (HIV-1) activity using a subclone of a monocytic cell line, U937

https://ir.soken.ac.jp/records/3989
https://ir.soken.ac.jp/records/3989
d140bf71-cc27-438e-827b-c7eccb6a5658
Item type 学術雑誌論文 / Journal Article(1)
公開日 2013-09-25
タイトル
タイトル A novel assay system for anti-human immunodeficiency virus type 1 (HIV-1) activity using a subclone of a monocytic cell line, U937
タイトル
言語 en
タイトル A novel assay system for anti-human immunodeficiency virus type 1 (HIV-1) activity using a subclone of a monocytic cell line, U937
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 MIYANOKUROSAKI, N

× MIYANOKUROSAKI, N

WEKO 2146

MIYANOKUROSAKI, N

Search repository
NAKASHIMA , H

× NAKASHIMA , H

WEKO 2147

NAKASHIMA , H

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ICHIYAMA , K

× ICHIYAMA , K

WEKO 2148

ICHIYAMA , K

Search repository
INAZAWA, K

× INAZAWA, K

WEKO 2149

INAZAWA, K

Search repository
TANABE, Hideyuki

× TANABE, Hideyuki

WEKO 368

TANABE, Hideyuki

Search repository
et, al.

× et, al.

WEKO 3119

et, al.

Search repository
著者別名 田辺, 秀之

× 田辺, 秀之

WEKO 367
NRID 1000050261178
e-Rad 50261178

田辺, 秀之

Search repository
抄録
内容記述タイプ Abstract
内容記述 A subclonal cl.1-14 cell was established from a monocytic cell line U937 by a limiting dilution method. The anti-HIV-1 activity of some antiviral compounds was evaluated in HIV-1-infected cl.1-14 cells. The results demonstrated that although AZT was a potent inhibitor of HIV-1 replication in cl.1-14 cells, its 50% effective concentration (EC50) values was 80 times higher than that in HIV-1 infected MT-4 cells; the EC50 of AZT was 0.16 microM and 0.002 microM in cl.1-14 and MT-4 cells, respectively. In contrast, the anti-HIV-1 activity of ddA, ddI and ddC in cl.1-14 cells was comparable to that in MT-4 cells. The antiviral activity of nevirapine, dextran sulfate, curdlan sulfate and T22 did not differ significantly between the cl.1-14 and MT-4 cells. The antiviral activity of several compounds in the HIV-1-infected cl.1-14 cells was similar to that in the HIV-1JR-FL-infected human peripheral macrophages. Our results suggest that cl.1-14 cell cultures are very useful for estimating antiviral activity and more advantageous than the use of peripheral blood macrophages.
書誌情報 Microbiology and Immunology
en : Microbiology and Immunology

巻 38, 号 10, p. 813-818, 発行日 1994
出版者
出版者 Wiley-Blackwell
ISSN
収録物識別子タイプ ISSN
収録物識別子 0385-5600
PubMed番号
識別子タイプ PMID
関連識別子 7869961
権利
権利情報 © Wiley-Blackwell
関連サイト
識別子タイプ URI
関連識別子 http://www.ncbi.nlm.nih.gov/pubmed/7869961
関連名称 PMC
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