{"_buckets": {"deposit": "49e69cbb-e69b-47c4-9b71-5b290f367574"}, "_deposit": {"created_by": 21, "id": "3989", "owners": [21], "pid": {"revision_id": 0, "type": "depid", "value": "3989"}, "status": "published"}, "_oai": {"id": "oai:ir.soken.ac.jp:00003989", "sets": ["293"]}, "author_link": ["2148", "368", "3119", "2147", "2146", "367", "2149"], "item_10001_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1994", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "10", "bibliographicPageEnd": "818", "bibliographicPageStart": "813", "bibliographicVolumeNumber": "38", "bibliographic_titles": [{"bibliographic_title": "Microbiology and Immunology "}, {"bibliographic_title": "Microbiology and Immunology ", "bibliographic_titleLang": "en"}]}]}, "item_10001_creator_3": {"attribute_name": "著者別名", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "田辺, 秀之"}], "nameIdentifiers": [{"nameIdentifier": "367", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "1000050261178", "nameIdentifierScheme": "NRID", "nameIdentifierURI": " "}, {"nameIdentifier": "50261178", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=50261178"}]}]}, "item_10001_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "A subclonal cl.1-14 cell was established from a monocytic cell line U937 by a limiting dilution method. The anti-HIV-1 activity of some antiviral compounds was evaluated in HIV-1-infected cl.1-14 cells. The results demonstrated that although AZT was a potent inhibitor of HIV-1 replication in cl.1-14 cells, its 50% effective concentration (EC50) values was 80 times higher than that in HIV-1 infected MT-4 cells; the EC50 of AZT was 0.16 microM and 0.002 microM in cl.1-14 and MT-4 cells, respectively. In contrast, the anti-HIV-1 activity of ddA, ddI and ddC in cl.1-14 cells was comparable to that in MT-4 cells. The antiviral activity of nevirapine, dextran sulfate, curdlan sulfate and T22 did not differ significantly between the cl.1-14 and MT-4 cells. The antiviral activity of several compounds in the HIV-1-infected cl.1-14 cells was similar to that in the HIV-1JR-FL-infected human peripheral macrophages. Our results suggest that cl.1-14 cell cultures are very useful for estimating antiviral activity and more advantageous than the use of peripheral blood macrophages.", "subitem_description_type": "Abstract"}]}, "item_10001_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Wiley-Blackwell"}]}, "item_10001_relation_13": {"attribute_name": "PubMed番号", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "7869961", "subitem_relation_type_select": "PMID"}}]}, "item_10001_relation_17": {"attribute_name": "関連サイト", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "PMC"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://www.ncbi.nlm.nih.gov/pubmed/7869961", "subitem_relation_type_select": "URI"}}]}, "item_10001_rights_15": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "© Wiley-Blackwell"}]}, "item_10001_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0385-5600", "subitem_source_identifier_type": "ISSN"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "MIYANOKUROSAKI, N"}], "nameIdentifiers": [{"nameIdentifier": "2146", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "NAKASHIMA , H"}], "nameIdentifiers": [{"nameIdentifier": "2147", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "ICHIYAMA , K"}], "nameIdentifiers": [{"nameIdentifier": "2148", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "INAZAWA, K"}], "nameIdentifiers": [{"nameIdentifier": "2149", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "TANABE, Hideyuki"}], "nameIdentifiers": [{"nameIdentifier": "368", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "et, al."}], "nameIdentifiers": [{"nameIdentifier": "3119", "nameIdentifierScheme": "WEKO"}]}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "A novel assay system for anti-human immunodeficiency virus type 1 (HIV-1) activity using a subclone of a monocytic cell line, U937", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "A novel assay system for anti-human immunodeficiency virus type 1 (HIV-1) activity using a subclone of a monocytic cell line, U937"}, {"subitem_title": "A novel assay system for anti-human immunodeficiency virus type 1 (HIV-1) activity using a subclone of a monocytic cell line, U937", "subitem_title_language": "en"}]}, "item_type_id": "10001", "owner": "21", "path": ["293"], "permalink_uri": "https://ir.soken.ac.jp/records/3989", "pubdate": {"attribute_name": "公開日", "attribute_value": "2013-09-25"}, "publish_date": "2013-09-25", "publish_status": "0", "recid": "3989", "relation": {}, "relation_version_is_last": true, "title": ["A novel assay system for anti-human immunodeficiency virus type 1 (HIV-1) activity using a subclone of a monocytic cell line, U937"], "weko_shared_id": -1}