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  1. 010 学術雑誌論文
  2. 桑島, 邦博 / KUWAJIMA, Kunihiro

Calcium-regulated interactions of human α-lactalbumin with bee venom melittin

https://ir.soken.ac.jp/records/4146
https://ir.soken.ac.jp/records/4146
2d462099-684e-492c-a718-fa569d84b97d
Item type 学術雑誌論文 / Journal Article(1)
公開日 2014-01-15
タイトル
タイトル Calcium-regulated interactions of human α-lactalbumin with bee venom melittin
タイトル
タイトル Calcium-regulated interactions of human α-lactalbumin with bee venom melittin
言語 en
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 PERMYAKOV, Eugene A

× PERMYAKOV, Eugene A

PERMYAKOV, Eugene A

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GRISHCHENKO, Valery M

× GRISHCHENKO, Valery M

GRISHCHENKO, Valery M

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KALINICHENKO, Lina P

× KALINICHENKO, Lina P

KALINICHENKO, Lina P

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ORLOV, Nikolay Y

× ORLOV, Nikolay Y

ORLOV, Nikolay Y

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KUWAJIMA, Kunihiro

× KUWAJIMA, Kunihiro

KUWAJIMA, Kunihiro

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SUGAI, Shintaro

× SUGAI, Shintaro

SUGAI, Shintaro

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著者別名 桑島, 邦博

× 桑島, 邦博

桑島, 邦博

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抄録
内容記述タイプ Abstract
内容記述 Affinity chromatography, fluorescence and circular dichroism spectroscopy methods have been used to study the interaction of melittin, a 26-residue peptide from bee venom, with Ca2+-binding α-lactalbumin from human milk. It has been revealed that melittin binds to the apo- and acidic states of α-lactalbumin while the presence of Ca2+ makes the interaction essentially weaker. The association constant for the complex of melittin with apo-α-lactalbumin determined from spectropolarimetric melittin-titration data is 2×107 M−1. The complexation of α-lactalbumin with melittin decreases its affinity to Ca2+ by three orders of magnitude. The interaction of apo-α-lactalbumin with melittin causes some changes in the environment of its aromatic amino acid residues and drastically alters the conformation of melittin, increasing its α-helical content but leaving its single tryptophan residue accessible to water. In the case of the acidic state of α-lactalbumin the interaction does not induce an increase in α-helical content of melittin.
書誌情報 Biophysical Chemistry
en : Biophysical Chemistry

巻 39, 号 2, p. 111-117, 発行日 1991-02
出版者
出版者 Elsevier
ISSN
収録物識別子タイプ ISSN
収録物識別子 0301-4622
PubMed番号
識別子タイプ PMID
関連識別子 2059662
DOI
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/0301-4622(91)85012-F
関連名称 10.1016/0301-4622(91)85012-F
権利
権利情報 © 1991 Published by Elsevier B.V.
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