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  1. 010 学術雑誌論文
  2. 大田, 竜也 / OTA, Tatsuya

The basis for haplotype complexity in VCBPs, an immune-type receptor in amphioxus.

https://ir.soken.ac.jp/records/5425
https://ir.soken.ac.jp/records/5425
272eb64c-5705-46e9-b86b-16461e380bda
Item type 学術雑誌論文 / Journal Article(1)
公開日 2017-02-23
タイトル
タイトル The basis for haplotype complexity in VCBPs, an immune-type receptor in amphioxus.
タイトル
言語 en
タイトル The basis for haplotype complexity in VCBPs, an immune-type receptor in amphioxus.
言語
言語 eng
キーワード
主題Scheme Other
主題 Variable region-containing chitin-binding protein
キーワード
主題Scheme Other
主題 Evolution
キーワード
主題Scheme Other
主題 Innate immunity
キーワード
主題Scheme Other
主題 Variable immunoglobulin
キーワード
主題Scheme Other
主題 polymorphism
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 DISHAW, Larry J

× DISHAW, Larry J

WEKO 6306

DISHAW, Larry J

Search repository
OTA, Tatsuya

× OTA, Tatsuya

WEKO 6307

OTA, Tatsuya

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MUELLER, M Gail

× MUELLER, M Gail

WEKO 6308

MUELLER, M Gail

Search repository
CANNON, John P

× CANNON, John P

WEKO 6309

CANNON, John P

Search repository
HAIRE, Robert N

× HAIRE, Robert N

WEKO 6310

HAIRE, Robert N

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GWATNEY, Natasha R

× GWATNEY, Natasha R

WEKO 6311

GWATNEY, Natasha R

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LITMAN, Ronda T

× LITMAN, Ronda T

WEKO 6312

LITMAN, Ronda T

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LITMAN, Gary W

× LITMAN, Gary W

WEKO 6313

LITMAN, Gary W

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著者別名 DISHAW, Larry J

× DISHAW, Larry J

WEKO 6867

DISHAW, Larry J

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OTA, Tatsuya

× OTA, Tatsuya

WEKO 6868

OTA, Tatsuya

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MUELLER, M Gail

× MUELLER, M Gail

WEKO 6869

MUELLER, M Gail

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CANNON, John P

× CANNON, John P

WEKO 6870

CANNON, John P

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HAIRE, Robert N

× HAIRE, Robert N

WEKO 6871

HAIRE, Robert N

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GWATNEY, Natasha R

× GWATNEY, Natasha R

WEKO 6872

GWATNEY, Natasha R

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LITMAN, Ronda T

× LITMAN, Ronda T

WEKO 6873

LITMAN, Ronda T

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LITMAN, Gary W

× LITMAN, Gary W

WEKO 6874

LITMAN, Gary W

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著者注記
Tatsuya, Ota : Department of Evolutionary Studies of Biosystems, The Graduate University for Advanced Studies *(Associate Professor)
抄録
内容記述タイプ Abstract
内容記述 Innate immune gene repertoires are restricted primarily to germline variation. Adaptive immunity, by comparison, relies on somatic variation of germline-encoded genes to generate extraordinarily large numbers of non-heritable antigen recognition motifs. Invertebrates lack the key features of vertebrate adaptive immunity, but have evolved a variety of alternative mechanisms to successfully protect the integrity of "self"; in many cases, these appear to be taxon-specific innovations. In the protochordate Branchiostoma floridae (amphioxus), the variable region-containing chitin-binding proteins (VCBPs) constitute a multigene family (comprised of VCBPs 1-5), which possesses features that are consistent with innate immune-type function. A large number of VCBP alleles and haplotypes are shown to exhibit levels of polymorphism exceeding the elevated overall levels determined for the whole amphioxus genome (JGI). VCBP genes of the 2 and 5 types are distinguished further by a highly polymorphic segment (exon 2) in the N-terminal immunoglobulin domain, defined previously as a "hypervariable region" or a "hotspot." Genomic deoxyribonucleic acid (DNA) and complementary DNA (cDNA) sequences from large numbers of animals representing different populations reveal further significant differences in sequence complexity within and across VCBP2/5 haplotypes that arise through overlapping mechanisms of genetic exchange, gene copy number variation as well as mutation and give rise to distinct allelic lineages. The collective observations suggest that mechanisms were in place at the time of divergence of the cephalochordates that could selectively hyperdiversify immune-type receptors within a multigene family.
論文注記
Published online : 22 July 2010
書誌情報 Immunogenetics
en : Immunogenetics

巻 62, 号 9, p. 623-631, 発行日 2010-09
雑誌情報
Publication Start Year : 1974
雑誌情報
Frequency : Monthly
出版者
出版者 Springer Berlin Heidelberg
ISSN
収録物識別子タイプ ISSN
収録物識別子 0093-7711
Online ISSN
収録物識別子タイプ ISSN
収録物識別子 1432-1211
書誌レコードID (NCID)
収録物識別子タイプ NCID
収録物識別子 AA11624885
PubMed番号
識別子タイプ PMID
関連識別子 20652563
PMC番号
PMC3707128
DOI
識別子タイプ DOI
関連識別子 http://dx.doi.org/10.1007/s00251-010-0464-x
関連名称 10.1007/s00251-010-0464-x <SpringerLink Abstract>
権利
権利情報 © Springer-Verlag 2010
関連サイト
識別子タイプ URI
関連識別子 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3707128/
関連名称 Article <PMC FREE Full Text : Author manuscript ; available in PMC 2013 July 10.>
関連サイト
識別子タイプ URI
関連識別子 http://link.springer.com/journal/251
関連名称 About Immunogenetics <Springer>
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