| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2017-02-23 |
| タイトル |
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タイトル |
Genomic complexity of the variable region-containing chitin-binding proteins in amphioxus. |
| タイトル |
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タイトル |
Genomic complexity of the variable region-containing chitin-binding proteins in amphioxus. |
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言語 |
en |
| 言語 |
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言語 |
eng |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
Animals |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
Carrier Proteins |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
Chitin |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
Chordata Nonvertebrate |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
Chromosomes Artificial Bacterial |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
Gene Dosage |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
Genetic Variation |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
Genome |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
Haplotypes |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
Immunoglobulin Variable Region |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
Models Genetic |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
Polymorphism Genetic |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
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主題 |
Transcription Genetic ＜NLM MeSH Terms＞ |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
metadata only access |
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アクセス権URI |
http://purl.org/coar/access_right/c_14cb |
| 著者 |
DISHAW, Larry J
MUELLER, M Gail
GWATNEY, Natasha
CANNON, John P
HAIRE, Robert N
LITMAN, Ronda T
AMEMIYA, Chris T
OTA, Tatsuya
ROWEN, Lee
GLUSMAN, Gustavo
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| 著者別名 |
DISHAW, Larry J
MUELLER, M Gail
GWATNEY, Natasha
CANNON, John P
HAIRE, Robert N
LITMAN, Ronda T
AMEMIYA, Chris T
OTA, Tatsuya
ROWEN, Lee
GLUSMAN, Gustavo
LITMAN, Gary W
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| 著者注記 |
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Tatsuya, Ota : Department of Evolutionary Studies of Biosystems, The Graduate University for Advanced Studies *(Associate Professor) |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
The variable region-containing chitin-binding proteins (VCBPs) are found in protochordates and consist of two tandem immunoglobulin variable (V)-type domains and a chitin-binding domain. We previously have shown that these polymorphic genes, which primarily are expressed in the gut, exhibit characteristics of immune genes. In this report, we describe VCBP genomic organization and characterize adjacent and intervening genetic features which may influence both their polymorphism and complex transcriptional repertoire. |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
VCBP genes 1, 2, 4, and 5 are encoded in a single contiguous gene-rich chromosomal region and VCBP3 is encoded in a separate locus. The VCBPs exhibit extensive haplotype variation, including copy number variation (CNV), indel polymorphism and a markedly elevated variation in repeat type and density. In at least one haplotype, inverted repeats occur more frequently than elsewhere in the genome. Multi-animal cDNA screening, as well as transcriptional profilingusing a novel transfection system, suggests that haplotype-specific transcriptional variants may contribute to VCBP genetic diversity. |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
The availability of the Branchiostoma floridae genome (Joint Genome Institute, Brafl1), along with BAC and PAC screening and sequencing described here, reveal that the relatively limited number of VCBP genes present in the amphioxus genome exhibit exceptionally high haplotype variation. These VCBP haplotypes contribute a diverse pool of allelic variants, which includes gene copy number variation, pseudogenes, and other polymorphisms, while contributing secondary effects on gene transcription as well. |
| 書誌情報 |
BMC genetics
en : BMC genetics
巻 9,
p. 78,
発行日 2008-12-01
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| 雑誌情報 |
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Other Title(s) : BioMed Central genetics |
| 雑誌情報 |
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Publication Start Year : 2000 |
| 雑誌情報 |
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Electronic only |
| 出版者 |
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出版者 |
BioMed Central / London |
| Online ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1471-2156 |
| 書誌レコードID (NCID) |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA12034956 |
| PubMed番号 |
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識別子タイプ |
PMID |
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関連識別子 |
19046437 |
| PMC番号 |
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PMC2632668 |
| DOI |
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識別子タイプ |
DOI |
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関連識別子 |
http://dx.doi.org/10.1186/1471-2156-9-78 |
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関連名称 |
10.1186/1471-2156-9-78 ＜Read free full text at BioMed Central＞ |
| 権利 |
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権利情報 |
© Dishaw et al; licensee BioMed Central Ltd. 2008 |
| 権利 |
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権利情報 |
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| 関連サイト |
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識別子タイプ |
URI |
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関連識別子 |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2632668/ |
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関連名称 |
Article ＜PMC FREE Full Txet＞ |
| 関連サイト |
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識別子タイプ |
URI |
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関連識別子 |
http://www.ncbi.nlm.nih.gov/pmc/journals/31/ |
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関連名称 |
Archive of BMC Gnenetics ＜PubMed Central＞ |
| 関連サイト |
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識別子タイプ |
URI |
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関連識別子 |
http://bmcgenet.biomedcentral.com/about |
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関連名称 |
About BMC Genetics ＜BioMed Central＞ |
