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Regulation of functional KCNQ1OT1 lncRNA by β-catenin.
https://ir.soken.ac.jp/records/5443
https://ir.soken.ac.jp/records/54431d6d6dfd-8a46-4769-9bec-f739085e5626
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
本文 / Article (1.2 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2016-08-16 | |||||
| タイトル | ||||||
| タイトル | Regulation of functional KCNQ1OT1 lncRNA by β-catenin. | |||||
| タイトル | ||||||
| タイトル | Regulation of functional KCNQ1OT1 lncRNA by β-catenin. | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
SUNAMURA, Naohiro
× SUNAMURA, Naohiro× OHIRA, Takahito× KATAOKA, Miki× INAOKA, Daigo× TANABE, Hideyuki× NAKAYAMA, Yuji× OSHIMURA, Mitsuo× KUGOH, Hiroyuki |
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| 著者注記 | ||||||
| 値 | Hideyuki, Tanabe : Department of Evolutionary Studies of Biosystems Science, School of Advanced Sciences, SOKENDAI (The Graduate University for Advanced Studies) *(Associate Professor) | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Long noncoding RNAs (lncRNAs) have been implicated in many biological processes through epigenetic mechanisms. We previously reported that KCNQ1OT1, an imprinted antisense lncRNA in the human KCNQ1 locus on chromosome 11p15.5, is involved in cis-limited silencing within an imprinted KCNQ1 cluster. Furthermore, aberration of KCNQ1OT1 transcription was observed with a high frequency in colorectal cancers. However, the molecular mechanism of the transcriptional regulation and the functional role of KCNQ1OT1 in colorectal cancer remain unclear. Here, we show that the KCNQ1OT1 transcriptional level was significantly increased in human colorectal cancer cells in which β-catenin was excessively accumulated in the nucleus. Additionally, overexpression of β-catenin resulted in an increase in KCNQ1OT1 lncRNA-coated territory. On the other hand, knockdown of β-catenin resulted in significant decrease of KCNQ1OT1 lncRNA-coated territory and an increase in the mRNA expression of the SLC22A18 and PHLDA2 genes that are regulated by KCNQ1OT1. We showed that β-catenin can promote KCNQ1OT1 transcription through direct binding to the KCNQ1OT1 promoter. Our evidence indicates that β-catenin signaling may contribute to development of colorectal cancer by functioning as a novel lncRNA regulatory factor via direct targeting of KCNQ1OT1. | |||||
| 論文注記 | ||||||
| 値 | Published online : 12 February 2016 | |||||
| 書誌情報 |
Scientific reports en : Scientific reports 巻 6, p. Article number : 20690 (2016), 発行日 2016-02-12 |
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| 雑誌情報 | ||||||
| 値 | Publication Start Year : 2011 | |||||
| 雑誌情報 | ||||||
| 値 | Frequency : Continuously updated | |||||
| 雑誌情報 | ||||||
| 値 | Scientific Reports is an online, open access journal from the publishers of Nature. | |||||
| 出版者 | ||||||
| 出版者 | Nature Publishing Group / London | |||||
| Online ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2045-2322 | |||||
| PubMed番号 | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 26868975 | |||||
| PMC番号 | ||||||
| 値 | PMC4751614 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | http://dx.doi.org/10.1038/srep20690 | |||||
| 関連名称 | 10.1038/srep20690 ＜Springer Nature Open Access Article＞ | |||||
| 権利 | ||||||
| 権利情報 | Scientific Reports is an open access journal. Articles in the journal are free to access, download, share, and re-use. | http://www.nature.com/srep/about/open-access | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.nature.com/srep/about | |||||
| 関連名称 | About Scientific reports ＜Springer Nature＞ | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
