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  1. 010 学術雑誌論文
  2. 田辺, 秀之 / TANABE, Hideyuki

Regulation of functional KCNQ1OT1 lncRNA by β-catenin.

https://ir.soken.ac.jp/records/5443
https://ir.soken.ac.jp/records/5443
1d6d6dfd-8a46-4769-9bec-f739085e5626
名前 / ファイル ライセンス アクション
srep20690.pdf 本文 / Article (1.2 MB)
license.icon
Item type 学術雑誌論文 / Journal Article(1)
公開日 2016-08-16
タイトル
タイトル Regulation of functional KCNQ1OT1 lncRNA by β-catenin.
タイトル
言語 en
タイトル Regulation of functional KCNQ1OT1 lncRNA by β-catenin.
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
著者 SUNAMURA, Naohiro

× SUNAMURA, Naohiro

WEKO 6331

SUNAMURA, Naohiro

Search repository
OHIRA, Takahito

× OHIRA, Takahito

WEKO 6332

OHIRA, Takahito

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KATAOKA, Miki

× KATAOKA, Miki

WEKO 6333

KATAOKA, Miki

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INAOKA, Daigo

× INAOKA, Daigo

WEKO 6334

INAOKA, Daigo

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TANABE, Hideyuki

× TANABE, Hideyuki

WEKO 6335

TANABE, Hideyuki

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NAKAYAMA, Yuji

× NAKAYAMA, Yuji

WEKO 6336

NAKAYAMA, Yuji

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OSHIMURA, Mitsuo

× OSHIMURA, Mitsuo

WEKO 6337

OSHIMURA, Mitsuo

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KUGOH, Hiroyuki

× KUGOH, Hiroyuki

WEKO 6338

KUGOH, Hiroyuki

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著者注記
値 Hideyuki, Tanabe : Department of Evolutionary Studies of Biosystems Science, School of Advanced Sciences, SOKENDAI (The Graduate University for Advanced Studies) *(Associate Professor)
抄録
内容記述タイプ Abstract
内容記述 Long noncoding RNAs (lncRNAs) have been implicated in many biological processes through epigenetic mechanisms. We previously reported that KCNQ1OT1, an imprinted antisense lncRNA in the human KCNQ1 locus on chromosome 11p15.5, is involved in cis-limited silencing within an imprinted KCNQ1 cluster. Furthermore, aberration of KCNQ1OT1 transcription was observed with a high frequency in colorectal cancers. However, the molecular mechanism of the transcriptional regulation and the functional role of KCNQ1OT1 in colorectal cancer remain unclear. Here, we show that the KCNQ1OT1 transcriptional level was significantly increased in human colorectal cancer cells in which β-catenin was excessively accumulated in the nucleus. Additionally, overexpression of β-catenin resulted in an increase in KCNQ1OT1 lncRNA-coated territory. On the other hand, knockdown of β-catenin resulted in significant decrease of KCNQ1OT1 lncRNA-coated territory and an increase in the mRNA expression of the SLC22A18 and PHLDA2 genes that are regulated by KCNQ1OT1. We showed that β-catenin can promote KCNQ1OT1 transcription through direct binding to the KCNQ1OT1 promoter. Our evidence indicates that β-catenin signaling may contribute to development of colorectal cancer by functioning as a novel lncRNA regulatory factor via direct targeting of KCNQ1OT1.
論文注記
値 Published online : 12 February 2016
書誌情報 Scientific reports
en : Scientific reports

巻 6, p. Article number : 20690 (2016), 発行日 2016-02-12
雑誌情報
値 Publication Start Year : 2011
雑誌情報
値 Frequency : Continuously updated
雑誌情報
値 Scientific Reports is an online, open access journal from the publishers of Nature.
出版者
出版者 Nature Publishing Group / London
Online ISSN
収録物識別子タイプ ISSN
収録物識別子 2045-2322
PubMed番号
関連タイプ isIdenticalTo
識別子タイプ PMID
関連識別子 26868975
PMC番号
値 PMC4751614
DOI
関連タイプ isIdenticalTo
識別子タイプ DOI
関連識別子 http://dx.doi.org/10.1038/srep20690
関連名称 10.1038/srep20690 <Springer Nature Open Access Article>
権利
権利情報 Scientific Reports is an open access journal. Articles in the journal are free to access, download, share, and re-use. | http://www.nature.com/srep/about/open-access
関連サイト
識別子タイプ URI
関連識別子 http://www.nature.com/srep/about
関連名称 About Scientific reports <Springer Nature>
著者版フラグ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
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