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  1. 010 学術雑誌論文
  2. 田辺, 秀之 / TANABE, Hideyuki

Direct evidence for pitavastatin induced chromatin structure change in the KLF4 gene in endothelial cells.

https://ir.soken.ac.jp/records/5454
https://ir.soken.ac.jp/records/5454
d4ea4949-6a93-4536-b844-24726789f7f0
名前 / ファイル ライセンス アクション
0096005asset.pdf 本文 / Article (1.3 MB)
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Item type 学術雑誌論文 / Journal Article(1)
公開日 2016-08-16
タイトル
タイトル Direct evidence for pitavastatin induced chromatin structure change in the KLF4 gene in endothelial cells.
タイトル
タイトル Direct evidence for pitavastatin induced chromatin structure change in the KLF4 gene in endothelial cells.
言語 en
言語
言語 eng
キーワード
言語 en
主題Scheme Other
主題 Chromatin
キーワード
言語 en
主題Scheme Other
主題 Chromatin Assembly and Disassembly
キーワード
言語 en
主題Scheme Other
主題 Gene Expression Regulation
キーワード
言語 en
主題Scheme Other
主題 Gene Knockdown Techniques
キーワード
言語 en
主題Scheme Other
主題 Human Umbilical Vein Endothelial Cells
キーワード
言語 en
主題Scheme Other
主題 Humans
キーワード
言語 en
主題Scheme Other
主題 Hydroxymethylglutaryl-CoA Reductase Inhibitors
キーワード
言語 en
主題Scheme Other
主題 Kruppel-Like Transcription Factors
キーワード
言語 en
主題Scheme Other
主題 MEF2 Transcription Factors
キーワード
言語 en
主題Scheme Other
主題 Nitric Oxide Synthase Type III
キーワード
言語 en
主題Scheme Other
主題 Quinolines
キーワード
言語 en
主題Scheme Other
主題 Response Elements
キーワード
言語 en
主題Scheme Other
主題 Thrombomodulin <NLM MeSH Terms>
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
著者 MAEJIMA, Takashi

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MAEJIMA, Takashi

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INOUE, Tsuyoshi

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INOUE, Tsuyoshi

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KANKI, Yasuharu

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KANKI, Yasuharu

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KOHRO, Takahide

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KOHRO, Takahide

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LI, Guoliang

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LI, Guoliang

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OHTA, Yoshihiro

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OHTA, Yoshihiro

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KIMURA, Hiroshi

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KIMURA, Hiroshi

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KOBAYASHI, Mika

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KOBAYASHI, Mika

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TAGUCHI, Akashi

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TAGUCHI, Akashi

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TSUTSUMI, Shuichi

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TSUTSUMI, Shuichi

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IWANARI, Hiroko

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YAMAMOTO, Shogo

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YAMAMOTO, Shogo

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ARUGA, Hirofumi

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ARUGA, Hirofumi

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DONG, Shoulian

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DONG, Shoulian

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STEVENS, Junko F

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STEVENS, Junko F

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POH, Huay Mei

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POH, Huay Mei

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YAMAMOTO, Kazuki

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KAWAMURA, Takeshi

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MIMURA, Imari

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SUEHIRO, Jun-ichi

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SUGIYAMA, Akira

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KANEKI, Kiyomi

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SHIBATA, Haruki

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YOSHINAKA, Yasunobu

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DOI, Takeshi

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ASANUMA, Akimune

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TANABE, Sohei

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TANAKA, Toshiya

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MINAMI, Takashi

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HAMAKUBO, Takao

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SAKAI, Juro

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NOZAKI, Naohito

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ABURATANI, Hiroyuki

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NANGAKU, Masaomi

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RUAN, Xiaoan

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TANABE, Hideyuki

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TANABE, Hideyuki

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RUAN, Yijun

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IHARA, Sigeo

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ENDO, Akira

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ENDO, Akira

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KODAMA, Tatsuhiko

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WADA, Youichiro

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WADA, Youichiro

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著者注記
Hideyuki, Tanabe:Department of Evolutionary Studies of Biosystems, School of Advanced Sciences, The Graduate University for Advanced Studies (Sokendai) *(Associate Professor)
抄録
内容記述タイプ Abstract
内容記述 Statins exert atheroprotective effects through the induction of specific transcriptional factors in multiple organs. In endothelial cells, statin-dependent atheroprotective gene up-regulation is mediated by Kruppel-like factor (KLF) family transcription factors. To dissect the mechanism of gene regulation, we sought to determine molecular targets by performing microarray analyses of human umbilical vein endothelial cells (HUVECs) treated with pitavastatin, and KLF4 was determined to be the most highly induced gene. In addition, it was revealed that the atheroprotective genes induced with pitavastatin, such as nitric oxide synthase 3 (NOS3) and thrombomodulin (THBD), were suppressed by KLF4 knockdown. Myocyte enhancer factor-2 (MEF2) family activation is reported to be involved in pitavastatin-dependent KLF4 induction. We focused on MEF2C among the MEF2 family members and identified a novel functional MEF2C binding site 148 kb upstream of the KLF4 gene by chromatin immunoprecipitation along with deep sequencing (ChIP-seq) followed by luciferase assay. By applying whole genome and quantitative chromatin conformation analysis {chromatin interaction analysis with paired end tag sequencing (ChIA-PET), and real time chromosome conformation capture (3C) assay}, we observed that the MEF2C-bound enhancer and transcription start site (TSS) of KLF4 came into closer spatial proximity by pitavastatin treatment. 3D-Fluorescence in situ hybridization (FISH) imaging supported the conformational change in individual cells. Taken together, dynamic chromatin conformation change was shown to mediate pitavastatin-responsive gene induction in endothelial cells.
論文注記
Published online : 2014 May 5
書誌情報 PLoS One
en : PLoS One

巻 9, 号 5, p. e96005, 発行日 2014-05-05
雑誌情報
Publication Start Year : 2006
雑誌情報
Frequency : Monthly
雑誌情報
A Peer-Reviewed, Open Access Journal, Electronic only
出版者
出版者 Public Library of Science / San Francisco, CA
Online ISSN
収録物識別子タイプ ISSN
収録物識別子 1932-6203
PubMed番号
関連タイプ isIdenticalTo
識別子タイプ PMID
関連識別子 24797675
PMC番号
PMC4010393
DOI
関連タイプ isIdenticalTo
識別子タイプ DOI
関連識別子 http://dx.doi.org/10.1371/journal.pone.0096005
関連名称 10.1371/journal.pone.0096005 <PLoS ONE Open Access Full Text>
権利
権利情報 © 2014 Maejima et al.
権利
権利情報 This is an open-access article distributed under the terms of the Creative Commons Attribution License.
関連サイト
識別子タイプ URI
関連識別子 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010393/
関連名称 Article <PMC Free Full text>
関連サイト
識別子タイプ URI
関連識別子 http://www.ncbi.nlm.nih.gov/pmc/journals/440/
関連名称 PLoS ONE Archive <PMC Journal List>
関連サイト
識別子タイプ URI
関連識別子 http://journals.plos.org/plosone/s/content-license
関連名称 Content License <PLoS ONE>
著者版フラグ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
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