| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2017-08-02 |
| タイトル |
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|
タイトル |
Characterisation of major histocompatibility complex class I genes in Japanese Ranidae frogs. |
| タイトル |
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タイトル |
Characterisation of major histocompatibility complex class I genes in Japanese Ranidae frogs. |
|
言語 |
en |
| 言語 |
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|
言語 |
eng |
| キーワード |
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主題Scheme |
Other |
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主題 |
Major histocompatibility complex |
| キーワード |
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主題Scheme |
Other |
|
主題 |
Selection |
| キーワード |
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主題Scheme |
Other |
|
主題 |
Rana |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Anura |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Major histocompatibility complex |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Selection |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Rana |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Anura |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
LAU, Quintin
IGAWA, Takeshi
KOMAKI, Shohei
SATTA, Yoko
|
| 著者別名 |
LAU, Quintin
IGAWA, Takeshi
KOMAKI, Shohei
SATTA, Yoko
|
| 著者注記 |
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Quintin, Lau：Department of Evolutionary Studies of Biosystems, Sokendai (The Graduate University for Advanced Studies) *(Post-doctoral researcher) |
| 著者注記 |
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Yoko, Satta：Department of Evolutionary Studies of Biosystems, Sokendai (The Graduate University for Advanced Studies) *(Professor) |
| 抄録 |
|
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内容記述タイプ |
Abstract |
|
内容記述 |
The major histocompatibility complex (MHC) is a key component of adaptive immunity in all jawed vertebrates, and understanding the evolutionary mechanisms that have shaped these genes in amphibians, one of the earliest terrestrial tetrapods, is important. We characterised MHC class I variation in three common Japanese Rana species (Rana japonica, Rana ornativentris and Rana tagoi tagoi) and identified a total of 60 variants from 21 individuals. We also found evolutionary signatures of gene duplication, recombination and balancing selection (including trans-species polymorphism), all of which drive increased MHC diversity. A unique feature of MHC class I from these three Ranidae species includes low synonymous differences per site (d S) within species, which we attribute to a more recent diversification of these sequences or recent gene duplication. The resulting higher d N/d S ratio relative to other anurans studied could be related to stronger selection pressure at peptide binding sites. This is one of the first studies to investigate MHC in Japanese amphibians and permits further exploration of the polygenetic factors associated with resistance to infectious diseases. |
| 論文注記 |
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Published online 2016 Jul 14. |
| 書誌情報 |
Immunogenetics
en : Immunogenetics
巻 68,
号 10,
p. 797-806,
発行日 2016-11
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| 雑誌情報 |
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Publication Start Year : 1974 |
| 雑誌情報 |
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Frequency : Monthly |
| 雑誌情報 |
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Electronic and print, print canceled 2017 |
| 出版者 |
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出版者 |
Springer Berlin Heidelberg |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0093-7711 |
| Online ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1432-1211 |
| 書誌レコードID (NCID) |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11624885 |
| PubMed番号 |
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27418258 |
|
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https://www.ncbi.nlm.nih.gov/pubmed/?term=27418258 |
| PMC番号 |
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PMC5056945 |
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056945/ |
| DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
http://dx.doi.org/10.1007/s00251-016-0934-x |
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関連名称 |
10.1007/s00251-016-0934-x ＜SpringaerLink FULL TEXT-ARTICLE＞ |
| 権利 |
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|
権利情報 |
© The Author(s) 2016 |
| 権利 |
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|
権利情報 |
※ This article is published with open access at Springerlink.com |
| 関連サイト |
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識別子タイプ |
URI |
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関連識別子 |
https://link.springer.com/journal/volumesAndIssues/251 |
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関連名称 |
Immunogenetics All Volumes & Issues ＜PMC FREE Full text＞ |
| 関連サイト |
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|
識別子タイプ |
URI |
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関連識別子 |
http://rd.springer.com/journal/251 |
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関連名称 |
About Immunogenetics ＜Springer Nature＞ |
| 著者版フラグ |
|
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出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
本文 / Article (563.7 kB)
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