{"_buckets": {"deposit": "9761b306-6648-4015-9231-8e8556787d65"}, "_deposit": {"created_by": 24, "id": "5560", "owners": [24], "pid": {"revision_id": 0, "type": "depid", "value": "5560"}, "status": "published"}, "_oai": {"id": "oai:ir.soken.ac.jp:00005560", "sets": ["285", "497"]}, "author_link": ["7021", "7020", "7017", "7018", "7015", "7019", "7016", "7022"], "item_10001_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2016-11", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "10", "bibliographicPageEnd": "806", "bibliographicPageStart": "797", "bibliographicVolumeNumber": "68", "bibliographic_titles": [{"bibliographic_title": "Immunogenetics"}, {"bibliographic_title": "Immunogenetics", "bibliographic_titleLang": "en"}]}]}, "item_10001_creator_3": {"attribute_name": "著者別名", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "LAU, Quintin"}], "nameIdentifiers": [{"nameIdentifier": "7016", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "IGAWA, Takeshi"}], "nameIdentifiers": [{"nameIdentifier": "7017", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "KOMAKI, Shohei"}], "nameIdentifiers": [{"nameIdentifier": "7018", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "SATTA, Yoko"}], "nameIdentifiers": [{"nameIdentifier": "7019", "nameIdentifierScheme": "WEKO"}]}]}, "item_10001_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "The major histocompatibility complex (MHC) is a key component of adaptive immunity in all jawed vertebrates, and understanding the evolutionary mechanisms that have shaped these genes in amphibians, one of the earliest terrestrial tetrapods, is important. We characterised MHC class I variation in three common Japanese Rana species (Rana japonica, Rana ornativentris and Rana tagoi tagoi) and identified a total of 60 variants from 21 individuals. We also found evolutionary signatures of gene duplication, recombination and balancing selection (including trans-species polymorphism), all of which drive increased MHC diversity. A unique feature of MHC class I from these three Ranidae species includes low synonymous differences per site (d S) within species, which we attribute to a more recent diversification of these sequences or recent gene duplication. The resulting higher d N/d S ratio relative to other anurans studied could be related to stronger selection pressure at peptide binding sites. This is one of the first studies to investigate MHC in Japanese amphibians and permits further exploration of the polygenetic factors associated with resistance to infectious diseases.", "subitem_description_type": "Abstract"}]}, "item_10001_link_33": {"attribute_name": "PubMed番号", "attribute_value_mlt": [{"subitem_link_text": "27418258", "subitem_link_url": "https://www.ncbi.nlm.nih.gov/pubmed/?term=27418258"}]}, "item_10001_link_34": {"attribute_name": "PMC番号", "attribute_value_mlt": [{"subitem_link_text": "PMC5056945", "subitem_link_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056945/"}]}, "item_10001_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Springer Berlin Heidelberg"}]}, "item_10001_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.1007/s00251-016-0934-x ＜SpringaerLink FULL TEXT-ARTICLE＞"}], "subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://dx.doi.org/10.1007/s00251-016-0934-x", "subitem_relation_type_select": "DOI"}}]}, "item_10001_relation_17": {"attribute_name": "関連サイト", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "Immunogenetics All Volumes \u0026 Issues ＜PMC FREE Full text＞ "}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://link.springer.com/journal/volumesAndIssues/251", "subitem_relation_type_select": "URI"}}, {"subitem_relation_name": [{"subitem_relation_name_text": "About Immunogenetics ＜Springer Nature＞"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://rd.springer.com/journal/251", "subitem_relation_type_select": "URI"}}]}, "item_10001_rights_15": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "© The Author(s) 2016"}, {"subitem_rights": "※ This article is published with open access at Springerlink.com"}]}, "item_10001_source_id_11": {"attribute_name": "書誌レコードID (NCID)", "attribute_value_mlt": [{"subitem_source_identifier": "AA11624885", "subitem_source_identifier_type": "NCID"}]}, "item_10001_source_id_26": {"attribute_name": "Online ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1432-1211", "subitem_source_identifier_type": "ISSN"}]}, "item_10001_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0093-7711", "subitem_source_identifier_type": "ISSN"}]}, "item_10001_text_23": {"attribute_name": "著者注記", "attribute_value_mlt": [{"subitem_text_value": "Quintin, Lau：Department of Evolutionary Studies of Biosystems, Sokendai (The Graduate University for Advanced Studies) *(Post-doctoral researcher)"}, {"subitem_text_value": "Yoko, Satta：Department of Evolutionary Studies of Biosystems, Sokendai (The Graduate University for Advanced Studies) *(Professor)"}]}, "item_10001_text_25": {"attribute_name": "雑誌情報", "attribute_value_mlt": [{"subitem_text_value": "Publication Start Year : 1974"}, {"subitem_text_value": "Frequency : Monthly"}, {"subitem_text_value": "Electronic and print, print canceled 2017"}]}, "item_10001_text_28": {"attribute_name": "論文注記", "attribute_value_mlt": [{"subitem_text_value": "Published online 2016 Jul 14."}]}, "item_10001_version_type_20": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "LAU, Quintin"}], "nameIdentifiers": [{"nameIdentifier": "7015", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "IGAWA, Takeshi"}], "nameIdentifiers": [{"nameIdentifier": "7020", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "KOMAKI, Shohei"}], "nameIdentifiers": [{"nameIdentifier": "7021", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "SATTA, Yoko"}], "nameIdentifiers": [{"nameIdentifier": "7022", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-08-02"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "10.1007_s00251-016-0934-x.pdf", "filesize": [{"value": "563.7 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_11", "mimetype": "application/pdf", "size": 563700.0, "url": {"label": "本文 / Article", "url": "https://ir.soken.ac.jp/record/5560/files/10.1007_s00251-016-0934-x.pdf"}, "version_id": "71979405-2398-4fd7-b059-18fef0ab00e4"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Major histocompatibility complex", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Selection", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Rana", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Anura", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Major histocompatibility complex", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Selection", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Rana", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Anura", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Characterisation of major histocompatibility complex class I genes in Japanese Ranidae frogs.", "item_titles": 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