{"_buckets": {"deposit": "21186823-4537-441f-ab43-8751e5c5d4d6"}, "_deposit": {"created_by": 24, "id": "5562", "owners": [24], "pid": {"revision_id": 0, "type": "depid", "value": "5562"}, "status": "published"}, "_oai": {"id": "oai:ir.soken.ac.jp:00005562", "sets": ["285"]}, "author_link": ["7038", "7055", "7045", "7040", "7039", "7046", "7051", "7058", "7060", "7056", "7037", "7035", "7053", "7052", "7041", "7057", "7043", "7042", "7047", "7036", "7054", "7059", "7049", "7050", "7044", "7048"], "item_10001_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2016-09-30", "bibliographicIssueDateType": "Issued"}, "bibliographicPageStart": "34349", "bibliographicVolumeNumber": "6", "bibliographic_titles": [{"bibliographic_title": "Scientific Reports"}, {"bibliographic_title": "Scientific Reports", "bibliographic_titleLang": "en"}]}]}, "item_10001_creator_3": {"attribute_name": "著者別名", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "SHIGENO-NAKAZAWA, Yoko"}], "nameIdentifiers": [{"nameIdentifier": "7035", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "KASAI, Takuma"}], "nameIdentifiers": [{"nameIdentifier": "7036", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "KI, Sewon"}], "nameIdentifiers": [{"nameIdentifier": "7037", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "KOSTYANOVSKAYA, Elina"}], "nameIdentifiers": [{"nameIdentifier": "7038", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "PAWLAK, Jana"}], "nameIdentifiers": [{"nameIdentifier": "7039", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "YAMAGISHI, Junya"}], "nameIdentifiers": [{"nameIdentifier": "7040", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "OKIMOTO, Noriaki"}], "nameIdentifiers": [{"nameIdentifier": "7041", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "TAIJI, Makoto"}], "nameIdentifiers": [{"nameIdentifier": "7042", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "OKADA, Mariko"}], "nameIdentifiers": [{"nameIdentifier": "7043", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "WESTBROOK, Jody"}], "nameIdentifiers": [{"nameIdentifier": "7044", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "SATTA, Yoko"}], "nameIdentifiers": [{"nameIdentifier": "7045", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "KIGAWA, Takanori"}], "nameIdentifiers": [{"nameIdentifier": "7046", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "IMAMOTO, Akira"}], "nameIdentifiers": [{"nameIdentifier": "7047", "nameIdentifierScheme": "WEKO"}]}]}, "item_10001_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "CRK and CRKL adapter proteins play essential roles in development and cancer through their SRC homology 2 and 3 (SH2 and SH3) domains. To gain insight into the origin of their shared functions, we have investigated their evolutionary history. We propose a term, crk/crkl ancestral (crka), for orthologs in invertebrates before the divergence of CRK and CRKL in the vertebrate ancestor. We have isolated two orthologs expressed in the choanoflagellate Monosiga brevicollis, a unicellular relative to the metazoans. Consistent with its highly-conserved three-dimensional structure, the SH2 domain of M. brevicollis crka1 can bind to the mammalian CRK/CRKL SH2 binding consensus phospho-YxxP, and to the SRC substrate/focal adhesion protein BCAR1 (p130(CAS)) in the presence of activated SRC. These results demonstrate an ancient origin of the CRK/CRKL SH2-target recognition specificity. Although BCAR1 orthologs exist only in metazoans as identified by an N-terminal SH3 domain, YxxP motifs, and a C-terminal FAT-like domain, some pre-metazoan transmembrane proteins include several YxxP repeats in their cytosolic region, suggesting that they are remotely related to the BCAR1 substrate domain. Since the tyrosine kinase SRC also has a pre-metazoan origin, co-option of BCAR1-related sequences may have rewired the crka-dependent network to mediate adhesion signals in the metazoan ancestor.", "subitem_description_type": "Abstract"}]}, "item_10001_link_33": {"attribute_name": "PubMed番号", "attribute_value_mlt": [{"subitem_link_text": "27686861", "subitem_link_url": "https://www.ncbi.nlm.nih.gov/pubmed/?term=27686861"}]}, "item_10001_link_34": {"attribute_name": "PMC番号", "attribute_value_mlt": [{"subitem_link_text": "PMC5043372", "subitem_link_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5043372/"}]}, "item_10001_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Nature Publishing Group / London"}]}, "item_10001_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "10.1038/srep34349 ＜Springer Nature Open Access Article＞"}], "subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://dx.doi.org/10.1038/srep34349", "subitem_relation_type_select": "DOI"}}]}, "item_10001_relation_17": {"attribute_name": "関連サイト", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "About Scientific reports ＜Springer Nature＞"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://www.nature.com/srep/", "subitem_relation_type_select": "URI"}}, {"subitem_relation_name": [{"subitem_relation_name_text": "Article ＜PMC FREE Full text＞"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5043372/", "subitem_relation_type_select": "URI"}}]}, "item_10001_rights_15": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "© The Author(s) 2016"}, {"subitem_rights": "Scientific Reports is an open access journal. Articles in the journal are free to access, download, share, and re-use. "}]}, "item_10001_source_id_26": {"attribute_name": "Online ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "2045-2322", "subitem_source_identifier_type": "ISSN"}]}, "item_10001_text_23": {"attribute_name": "著者注記", "attribute_value_mlt": [{"subitem_text_value": "Yoko Satta：Department of Evolutionary Studies of Biosystems, The Graduate University of Advanced Studies *(Professor)"}]}, "item_10001_text_25": {"attribute_name": "雑誌情報", "attribute_value_mlt": [{"subitem_text_value": "Publication Start Year : 2011"}, {"subitem_text_value": "Frequency : Continuously updated"}, {"subitem_text_value": "Scientific Reports is an online, open access journal from the publishers of Nature. "}]}, "item_10001_version_type_20": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "SHIGENO-NAKAZAWA, Yoko"}], "nameIdentifiers": [{"nameIdentifier": "7048", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "KASAI, Takuma"}], "nameIdentifiers": [{"nameIdentifier": "7049", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "KI, Sewon"}], "nameIdentifiers": [{"nameIdentifier": "7050", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "KOSTYANOVSKAYA, Elina"}], "nameIdentifiers": [{"nameIdentifier": "7051", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "PAWLAK, Jana"}], "nameIdentifiers": [{"nameIdentifier": "7052", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "YAMAGISHI, Junya"}], "nameIdentifiers": [{"nameIdentifier": "7053", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "OKIMOTO, Noriaki"}], "nameIdentifiers": [{"nameIdentifier": "7054", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "TAIJI, Makoto"}], "nameIdentifiers": [{"nameIdentifier": "7055", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "OKADA, Mariko"}], "nameIdentifiers": [{"nameIdentifier": "7056", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "WESTBROOK, Jody"}], "nameIdentifiers": [{"nameIdentifier": "7057", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "SATTA, Yoko"}], "nameIdentifiers": [{"nameIdentifier": "7058", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "KIGAWA, Takanori"}], "nameIdentifiers": [{"nameIdentifier": "7059", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "IMAMOTO, Akira"}], "nameIdentifiers": [{"nameIdentifier": "7060", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-08-02"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "srep34349.pdf", "filesize": [{"value": "1.8 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_11", "mimetype": "application/pdf", "size": 1800000.0, "url": {"label": "本文 / Article", "url": "https://ir.soken.ac.jp/record/5562/files/srep34349.pdf"}, "version_id": "2ee8d434-0e3b-4e54-a73e-12008d0c3925"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "A pre-metazoan origin of the CRK gene family and co-opted signaling network.", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "A pre-metazoan origin of the CRK gene family and co-opted signaling network."}, {"subitem_title": "A pre-metazoan origin of the CRK gene family and co-opted signaling network.", "subitem_title_language": "en"}]}, "item_type_id": "10001", "owner": "24", "path": ["285"], "permalink_uri": "https://ir.soken.ac.jp/records/5562", "pubdate": {"attribute_name": "公開日", "attribute_value": "2017-08-02"}, "publish_date": "2017-08-02", "publish_status": "0", "recid": "5562", "relation": {}, "relation_version_is_last": true, "title": ["A pre-metazoan origin of the CRK gene family and co-opted signaling network."], "weko_shared_id": -1}