| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2017-08-02 |
| タイトル |
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タイトル |
A pre-metazoan origin of the CRK gene family and co-opted signaling network. |
| タイトル |
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タイトル |
A pre-metazoan origin of the CRK gene family and co-opted signaling network. |
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言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
SHIGENO-NAKAZAWA, Yoko
KASAI, Takuma
KI, Sewon
KOSTYANOVSKAYA, Elina
PAWLAK, Jana
YAMAGISHI, Junya
OKIMOTO, Noriaki
TAIJI, Makoto
OKADA, Mariko
WESTBROOK, Jody
SATTA, Yoko
KIGAWA, Takanori
IMAMOTO, Akira
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| 著者別名 |
SHIGENO-NAKAZAWA, Yoko
KASAI, Takuma
KI, Sewon
KOSTYANOVSKAYA, Elina
PAWLAK, Jana
YAMAGISHI, Junya
OKIMOTO, Noriaki
TAIJI, Makoto
OKADA, Mariko
WESTBROOK, Jody
SATTA, Yoko
KIGAWA, Takanori
IMAMOTO, Akira
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| 著者注記 |
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Yoko Satta：Department of Evolutionary Studies of Biosystems, The Graduate University of Advanced Studies *(Professor) |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
CRK and CRKL adapter proteins play essential roles in development and cancer through their SRC homology 2 and 3 (SH2 and SH3) domains. To gain insight into the origin of their shared functions, we have investigated their evolutionary history. We propose a term, crk/crkl ancestral (crka), for orthologs in invertebrates before the divergence of CRK and CRKL in the vertebrate ancestor. We have isolated two orthologs expressed in the choanoflagellate Monosiga brevicollis, a unicellular relative to the metazoans. Consistent with its highly-conserved three-dimensional structure, the SH2 domain of M. brevicollis crka1 can bind to the mammalian CRK/CRKL SH2 binding consensus phospho-YxxP, and to the SRC substrate/focal adhesion protein BCAR1 (p130(CAS)) in the presence of activated SRC. These results demonstrate an ancient origin of the CRK/CRKL SH2-target recognition specificity. Although BCAR1 orthologs exist only in metazoans as identified by an N-terminal SH3 domain, YxxP motifs, and a C-terminal FAT-like domain, some pre-metazoan transmembrane proteins include several YxxP repeats in their cytosolic region, suggesting that they are remotely related to the BCAR1 substrate domain. Since the tyrosine kinase SRC also has a pre-metazoan origin, co-option of BCAR1-related sequences may have rewired the crka-dependent network to mediate adhesion signals in the metazoan ancestor. |
| 書誌情報 |
Scientific Reports
en : Scientific Reports
巻 6,
p. 34349,
発行日 2016-09-30
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| 雑誌情報 |
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Publication Start Year : 2011 |
| 雑誌情報 |
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Frequency : Continuously updated |
| 雑誌情報 |
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Scientific Reports is an online, open access journal from the publishers of Nature. |
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出版者 |
Nature Publishing Group / London |
| Online ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
2045-2322 |
| PubMed番号 |
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27686861 |
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https://www.ncbi.nlm.nih.gov/pubmed/?term=27686861 |
| PMC番号 |
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PMC5043372 |
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5043372/ |
| DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
http://dx.doi.org/10.1038/srep34349 |
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関連名称 |
10.1038/srep34349 ＜Springer Nature Open Access Article＞ |
| 権利 |
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権利情報 |
© The Author(s) 2016 |
| 権利 |
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権利情報 |
Scientific Reports is an open access journal. Articles in the journal are free to access, download, share, and re-use. |
| 関連サイト |
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識別子タイプ |
URI |
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関連識別子 |
http://www.nature.com/srep/ |
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関連名称 |
About Scientific reports ＜Springer Nature＞ |
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識別子タイプ |
URI |
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関連識別子 |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5043372/ |
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関連名称 |
Article ＜PMC FREE Full text＞ |
| 著者版フラグ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
本文 / Article (1.8 MB)
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