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A pre-metazoan origin of the CRK gene family and co-opted signaling network.
https://ir.soken.ac.jp/records/5562
https://ir.soken.ac.jp/records/556221f941b0-c36d-4966-9a90-0cd4f1f356d9
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
本文 / Article (1.8 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2017-08-02 | |||||
| タイトル | ||||||
| タイトル | A pre-metazoan origin of the CRK gene family and co-opted signaling network. | |||||
| タイトル | ||||||
| タイトル | A pre-metazoan origin of the CRK gene family and co-opted signaling network. | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
SHIGENO-NAKAZAWA, Yoko
× SHIGENO-NAKAZAWA, Yoko× KASAI, Takuma× KI, Sewon× KOSTYANOVSKAYA, Elina× PAWLAK, Jana× YAMAGISHI, Junya× OKIMOTO, Noriaki× TAIJI, Makoto× OKADA, Mariko× WESTBROOK, Jody× SATTA, Yoko× KIGAWA, Takanori× IMAMOTO, Akira |
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| 著者別名 |
SHIGENO-NAKAZAWA, Yoko
× SHIGENO-NAKAZAWA, Yoko× KASAI, Takuma× KI, Sewon× KOSTYANOVSKAYA, Elina× PAWLAK, Jana× YAMAGISHI, Junya× OKIMOTO, Noriaki× TAIJI, Makoto× OKADA, Mariko× WESTBROOK, Jody× SATTA, Yoko× KIGAWA, Takanori× IMAMOTO, Akira |
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| 著者注記 | ||||||
| 値 | Yoko Satta：Department of Evolutionary Studies of Biosystems, The Graduate University of Advanced Studies *(Professor) | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | CRK and CRKL adapter proteins play essential roles in development and cancer through their SRC homology 2 and 3 (SH2 and SH3) domains. To gain insight into the origin of their shared functions, we have investigated their evolutionary history. We propose a term, crk/crkl ancestral (crka), for orthologs in invertebrates before the divergence of CRK and CRKL in the vertebrate ancestor. We have isolated two orthologs expressed in the choanoflagellate Monosiga brevicollis, a unicellular relative to the metazoans. Consistent with its highly-conserved three-dimensional structure, the SH2 domain of M. brevicollis crka1 can bind to the mammalian CRK/CRKL SH2 binding consensus phospho-YxxP, and to the SRC substrate/focal adhesion protein BCAR1 (p130(CAS)) in the presence of activated SRC. These results demonstrate an ancient origin of the CRK/CRKL SH2-target recognition specificity. Although BCAR1 orthologs exist only in metazoans as identified by an N-terminal SH3 domain, YxxP motifs, and a C-terminal FAT-like domain, some pre-metazoan transmembrane proteins include several YxxP repeats in their cytosolic region, suggesting that they are remotely related to the BCAR1 substrate domain. Since the tyrosine kinase SRC also has a pre-metazoan origin, co-option of BCAR1-related sequences may have rewired the crka-dependent network to mediate adhesion signals in the metazoan ancestor. | |||||
| 書誌情報 |
Scientific Reports en : Scientific Reports 巻 6, p. 34349, 発行日 2016-09-30 |
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| 雑誌情報 | ||||||
| 値 | Publication Start Year : 2011 | |||||
| 雑誌情報 | ||||||
| 値 | Frequency : Continuously updated | |||||
| 雑誌情報 | ||||||
| 値 | Scientific Reports is an online, open access journal from the publishers of Nature. | |||||
| 出版者 | ||||||
| 出版者 | Nature Publishing Group / London | |||||
| Online ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2045-2322 | |||||
| PubMed番号 | ||||||
| 表示名 | 27686861 | |||||
| URL | https://www.ncbi.nlm.nih.gov/pubmed/?term=27686861 | |||||
| PMC番号 | ||||||
| 表示名 | PMC5043372 | |||||
| URL | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5043372/ | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | http://dx.doi.org/10.1038/srep34349 | |||||
| 関連名称 | 10.1038/srep34349 ＜Springer Nature Open Access Article＞ | |||||
| 権利 | ||||||
| 権利情報 | © The Author(s) 2016 | |||||
| 権利 | ||||||
| 権利情報 | Scientific Reports is an open access journal. Articles in the journal are free to access, download, share, and re-use. | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.nature.com/srep/ | |||||
| 関連名称 | About Scientific reports ＜Springer Nature＞ | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5043372/ | |||||
| 関連名称 | Article ＜PMC FREE Full text＞ | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
