| Item type |
学位論文 / Thesis or Dissertation(1) |
| 公開日 |
2010-02-22 |
| タイトル |
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|
タイトル |
モザイクタンパク質としてのセリンプロテアーゼとそのインヒビターの分子進化 |
| タイトル |
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タイトル |
Evolutionary Features of Serine Protease and its Inhibitor as Mosaic Proteins |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_46ec |
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資源タイプ |
thesis |
| 著者名 |
池尾, 一穂
|
| フリガナ |
イケオ, カズホ
|
| 著者 |
IKEO, Kazuho
|
| 学位授与機関 |
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学位授与機関名 |
総合研究大学院大学 |
| 学位名 |
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学位名 |
博士（理学） |
| 学位記番号 |
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内容記述タイプ |
Other |
|
内容記述 |
総研大甲第16号 |
| 研究科 |
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|
値 |
生命科学研究科 |
| 専攻 |
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|
値 |
18 遺伝学専攻 |
| 学位授与年月日 |
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学位授与年月日 |
1992-03-16 |
| 学位授与年度 |
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|
|
1991 |
| 要旨 |
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内容記述タイプ |
Other |
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内容記述 |
The serine protease is a typical example of the mosaic protein.<br /> It is a suitable material for studying molecular evolution of genes<br /> and proteins, because a gene (and thus a protein) is now considered<br /> to be composed of domains of independent evolutionary origins. The<br /> serine protease has a protease domain and a domain called the<br />kringle structure. The kringle structure is a typical motif that has a<br />pattern of disulfide bridges. The Kuniz-type protease inhibitor, a<br />protein inhibitor of the serine protease, has also a smaller size of the<br />kringle structure called the minikringle.<br /> The purpose of this dissertation is to study the molecular<br />evolution of the serine proteases and the Kunitz-type protease<br />inhibitors, in order to elucidate the evolutionary process of mosaic<br />proteins. To accomplish this purpose, I studied the evolutionary<br />dynamics of these proteins from various aspects of molecular<br />evolution in the following chapters.<br /> In Chapter 2, I explained the kringle structures of the serine<br /> proteases and showed characteristic features of its molecular<br /> evolution. In Chapter 3, I discussed the difference in evolutionary<br /> pattern between the protease domains and kringle domains, in order<br />to exemplify domain shuffling occurring in the evolutionary course<br />of mosaic proteins. The molecular evolution of the Kunitz-type<br />protease inhibitors was discussed in Chapter 4, which explored the<br /> evolutionary origin of the Kunitz-type domains inserted into various<br />proteins. In Chapter 5, I described the evolutionary relationships<br /> between the kringle and kringle-like structures, for the purpose of<br />showing the possibility that these structures have undergone<br /> indepcndent courses in molecular evolution of the mosaic proteins.<br /> In conclusion, as mentioned in Chapter 6, I emphasized the<br /> importance of domain shuffling in evolution of mosaic proteins. |
| 所蔵 |
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値 |
有 |
| フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
要旨・審査要旨 / Abstract, Screening Result (186.4 kB)
