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モザイクタンパク質としてのセリンプロテアーゼとそのインヒビターの分子進化
https://ir.soken.ac.jp/records/877
https://ir.soken.ac.jp/records/877febaae60-b341-47f1-92cf-89449afb211e
名前 / ファイル | ライセンス | アクション |
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要旨・審査要旨 / Abstract, Screening Result (186.4 kB)
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本文 (3.8 MB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2010-02-22 | |||||
タイトル | ||||||
タイトル | モザイクタンパク質としてのセリンプロテアーゼとそのインヒビターの分子進化 | |||||
タイトル | ||||||
タイトル | Evolutionary Features of Serine Protease and its Inhibitor as Mosaic Proteins | |||||
言語 | en | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_46ec | |||||
資源タイプ | thesis | |||||
著者名 |
池尾, 一穂
× 池尾, 一穂 |
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フリガナ |
イケオ, カズホ
× イケオ, カズホ |
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著者 |
IKEO, Kazuho
× IKEO, Kazuho |
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学位授与機関 | ||||||
学位授与機関名 | 総合研究大学院大学 | |||||
学位名 | ||||||
学位名 | 博士(理学) | |||||
学位記番号 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 総研大甲第16号 | |||||
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値 | 生命科学研究科 | |||||
専攻 | ||||||
値 | 18 遺伝学専攻 | |||||
学位授与年月日 | ||||||
学位授与年月日 | 1992-03-16 | |||||
学位授与年度 | ||||||
値 | 1991 | |||||
要旨 | ||||||
内容記述タイプ | Other | |||||
内容記述 | The serine protease is a typical example of the mosaic protein.<br /> It is a suitable material for studying molecular evolution of genes<br /> and proteins, because a gene (and thus a protein) is now considered<br /> to be composed of domains of independent evolutionary origins. The<br /> serine protease has a protease domain and a domain called the<br />kringle structure. The kringle structure is a typical motif that has a<br />pattern of disulfide bridges. The Kuniz-type protease inhibitor, a<br />protein inhibitor of the serine protease, has also a smaller size of the<br />kringle structure called the minikringle.<br /> The purpose of this dissertation is to study the molecular<br />evolution of the serine proteases and the Kunitz-type protease<br />inhibitors, in order to elucidate the evolutionary process of mosaic<br />proteins. To accomplish this purpose, I studied the evolutionary<br />dynamics of these proteins from various aspects of molecular<br />evolution in the following chapters.<br /> In Chapter 2, I explained the kringle structures of the serine<br /> proteases and showed characteristic features of its molecular<br /> evolution. In Chapter 3, I discussed the difference in evolutionary<br /> pattern between the protease domains and kringle domains, in order<br />to exemplify domain shuffling occurring in the evolutionary course<br />of mosaic proteins. The molecular evolution of the Kunitz-type<br />protease inhibitors was discussed in Chapter 4, which explored the<br /> evolutionary origin of the Kunitz-type domains inserted into various<br />proteins. In Chapter 5, I described the evolutionary relationships<br /> between the kringle and kringle-like structures, for the purpose of<br />showing the possibility that these structures have undergone<br /> indepcndent courses in molecular evolution of the mosaic proteins.<br /> In conclusion, as mentioned in Chapter 6, I emphasized the<br /> importance of domain shuffling in evolution of mosaic proteins. | |||||
所蔵 | ||||||
値 | 有 | |||||
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内容記述タイプ | Other | |||||
内容記述 | application/pdf |