{"_buckets": {"deposit": "058de96d-d192-4e33-ba7c-11a5dc06d6dc"}, "_deposit": {"created_by": 1, "id": "877", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "877"}, "status": "published"}, "_oai": {"id": "oai:ir.soken.ac.jp:00000877", "sets": ["20"]}, "author_link": ["9802", "9803", "9801"], "item_1_biblio_info_21": {"attribute_name": "書誌情報（ソート用）", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1992-03-16", "bibliographicIssueDateType": "Issued"}, "bibliographic_titles": [{}]}]}, "item_1_creator_2": {"attribute_name": "著者名", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "池尾, 一穂"}], "nameIdentifiers": [{"nameIdentifier": "9801", "nameIdentifierScheme": "WEKO"}]}]}, "item_1_creator_3": {"attribute_name": "フリガナ", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "イケオ, カズホ"}], "nameIdentifiers": [{"nameIdentifier": "9802", "nameIdentifierScheme": "WEKO"}]}]}, "item_1_date_granted_11": {"attribute_name": "学位授与年月日", "attribute_value_mlt": [{"subitem_dategranted": "1992-03-16"}]}, "item_1_degree_grantor_5": {"attribute_name": "学位授与機関", "attribute_value_mlt": [{"subitem_degreegrantor": [{"subitem_degreegrantor_name": "総合研究大学院大学"}]}]}, "item_1_degree_name_6": {"attribute_name": "学位名", "attribute_value_mlt": [{"subitem_degreename": "博士（理学）"}]}, "item_1_description_1": {"attribute_name": "ID", "attribute_value_mlt": [{"subitem_description": "1992016", "subitem_description_type": "Other"}]}, "item_1_description_12": {"attribute_name": "要旨", "attribute_value_mlt": [{"subitem_description": "　　The serine protease is a typical example of the mosaic protein.\u003cbr /\u003e It is a suitable material for studying molecular evolution of genes\u003cbr /\u003e and proteins, because a gene (and thus a protein) is now considered\u003cbr /\u003e to be composed of domains of independent evolutionary origins.　The\u003cbr /\u003e serine protease has a protease domain and a domain called the\u003cbr /\u003ekringle structure. The kringle structure is a typical motif that has a\u003cbr /\u003epattern of disulfide bridges. The Kuniz-type protease inhibitor, a\u003cbr /\u003eprotein inhibitor of the serine protease, has also a smaller size of the\u003cbr /\u003ekringle structure called the minikringle.\u003cbr /\u003e　　The purpose of this dissertation is to study the molecular\u003cbr /\u003eevolution of the serine proteases and the Kunitz-type protease\u003cbr /\u003einhibitors, in order to elucidate the evolutionary process of mosaic\u003cbr /\u003eproteins. 　　To accomplish this purpose, I studied the evolutionary\u003cbr /\u003edynamics of these proteins from various aspects of molecular\u003cbr /\u003eevolution in the following chapters.\u003cbr /\u003e　　In Chapter 2, I explained the kringle structures of the serine\u003cbr /\u003e proteases and showed characteristic features of its molecular\u003cbr /\u003e evolution. In Chapter 3, I discussed the difference in evolutionary\u003cbr /\u003e pattern between the protease domains and kringle domains, in order\u003cbr /\u003eto exemplify domain shuffling occurring in the evolutionary course\u003cbr /\u003eof mosaic proteins. The molecular evolution of the Kunitz-type\u003cbr /\u003eprotease inhibitors was discussed in Chapter 4, which explored the\u003cbr /\u003e evolutionary origin of the Kunitz-type domains inserted into various\u003cbr /\u003eproteins.　In Chapter 5, I described the evolutionary relationships\u003cbr /\u003e between the kringle and kringle-like structures, for the purpose of\u003cbr /\u003eshowing the possibility that these structures have undergone\u003cbr /\u003e indepcndent courses　in molecular evolution of the mosaic proteins.\u003cbr /\u003e　　　In conclusion, as mentioned in Chapter 6, I emphasized the\u003cbr /\u003e importance of domain shuffling in evolution of mosaic proteins.", "subitem_description_type": "Other"}]}, "item_1_description_18": {"attribute_name": "フォーマット", "attribute_value_mlt": [{"subitem_description": "application/pdf", "subitem_description_type": "Other"}]}, "item_1_description_7": {"attribute_name": "学位記番号", "attribute_value_mlt": [{"subitem_description": "総研大甲第16号", "subitem_description_type": "Other"}]}, "item_1_select_14": {"attribute_name": "所蔵", "attribute_value_mlt": [{"subitem_select_item": "有"}]}, "item_1_select_8": {"attribute_name": "研究科", "attribute_value_mlt": [{"subitem_select_item": "生命科学研究科"}]}, "item_1_select_9": {"attribute_name": "専攻", "attribute_value_mlt": [{"subitem_select_item": "18 遺伝学専攻"}]}, "item_1_text_10": {"attribute_name": "学位授与年度", "attribute_value_mlt": [{"subitem_text_value": "1991"}]}, "item_1_text_20": {"attribute_name": "業務メモ", "attribute_value_mlt": [{"subitem_text_value": "（2018年2月19日）本籍など個人情報の記載がある旧要旨・審査要旨を個人情報のない新しいものに差し替えた。承諾書等未確認。要確認該当項目修正のこと。"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "IKEO, Kazuho", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "9803", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2016-02-17"}], "displaytype": "simple", "download_preview_message": "", "file_order": 0, "filename": "甲16_要旨.pdf", "filesize": [{"value": "186.4 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_11", "mimetype": "application/pdf", "size": 186400.0, "url": {"label": "要旨・審査要旨 / Abstract, Screening Result", "url": "https://ir.soken.ac.jp/record/877/files/甲16_要旨.pdf"}, "version_id": "654d4d62-5188-43c9-a1a3-d3ee1e3e0785"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2016-02-17"}], "displaytype": "simple", "download_preview_message": "", "file_order": 1, "filename": "甲16_本文.pdf", "filesize": [{"value": "3.8 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_11", "mimetype": "application/pdf", "size": 3800000.0, "url": {"label": "本文", "url": "https://ir.soken.ac.jp/record/877/files/甲16_本文.pdf"}, "version_id": "2581eb0c-908e-4916-813a-efd81458f6bf"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "thesis", "resourceuri": "http://purl.org/coar/resource_type/c_46ec"}]}, "item_title": "モザイクタンパク質としてのセリンプロテアーゼとそのインヒビターの分子進化", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "モザイクタンパク質としてのセリンプロテアーゼとそのインヒビターの分子進化"}, {"subitem_title": "Evolutionary Features of Serine Protease and its Inhibitor as Mosaic Proteins", "subitem_title_language": "en"}]}, "item_type_id": "1", "owner": "1", "path": ["20"], "permalink_uri": "https://ir.soken.ac.jp/records/877", "pubdate": {"attribute_name": "公開日", "attribute_value": "2010-02-22"}, "publish_date": "2010-02-22", "publish_status": "0", "recid": "877", "relation": {}, "relation_version_is_last": true, "title": ["モザイクタンパク質としてのセリンプロテアーゼとそのインヒビターの分子進化"], "weko_shared_id": 1}