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  1. 020 学位論文
  2. 生命科学研究科
  3. 18 遺伝学専攻

Comprehensive characterization of differentially methylated regions associated with mouse imprinted genes

https://ir.soken.ac.jp/records/1020
https://ir.soken.ac.jp/records/1020
d9f3e7ef-de59-494b-a0cd-9bc0fe34d46f
名前 / ファイル ライセンス アクション
甲957_要旨.pdf 要旨・審査要旨 (207.7 kB)
甲957_本文.pdf 本文 (1.6 MB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2010-02-22
タイトル
タイトル Comprehensive characterization of differentially methylated regions associated with mouse imprinted genes
タイトル
タイトル Comprehensive characterization of differentially methylated regions associated with mouse imprinted genes
言語 en
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_46ec
資源タイプ thesis
著者名 小林, 久人

× 小林, 久人

小林, 久人

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フリガナ コバヤシ, ヒサト

× コバヤシ, ヒサト

コバヤシ, ヒサト

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著者 KOBAYASHI, Hisato

× KOBAYASHI, Hisato

en KOBAYASHI, Hisato

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学位授与機関
学位授与機関名 総合研究大学院大学
学位名
学位名 博士(理学)
学位記番号
内容記述タイプ Other
内容記述 総研大甲第957号
研究科
値 生命科学研究科
専攻
値 18 遺伝学専攻
学位授与年月日
学位授与年月日 2006-03-24
学位授与年度
値 2005
要旨
内容記述タイプ Other
内容記述 Imprinted genes in mammals show monoallelic expression dependent<br /> on parental origin and are often associated with differentially methylated regions<br /> (DMRs). There are two classes of DMR: germline DMRs acquire gamete-specific<br /> methylation in either spermatogenesis or oogenesis and maintain the allelic<br /> methylation differences throughout development; secondary DMRs establish<br /> differential methylation patterns after fertilization. Targeted disruption of some<br /> germline DMRs showed that they dictate the allelic expression of nearby<br /> imprinted genes and the establishment of the allelic methylation of secondary<br /> DMRs. However, how the imprinting machinery recognizes germline DMRs is<br /> unknown. As a step toward elucidating the sequence features of the germline<br /> DMRs, I have determined the extents and boundaries of 15 germline<br /> mouse DMRs (including 12 maternally methylated and 3 paternally methylated ones) in<br /> 12.5-dpc embryos and sperm by bisulfite sequencing. I found that the average<br /> size of the DMRs was 2.7 kb and that their average G+C content was 54.2%.<br /> Oligonucleotide content analysis of the DMR sequences revealed that, although<br /> they are generally CpG rich, the paternally methylated DMRs contain less CpGs<br /> than the maternally methylated ones. Furthermore, based on the SOM analysis,<br /> I found that most germline DMRs have features distinct from typical mouse<br /> sequences. My findings provide a basis for the further characterization of DMRs.<br />
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