| Item type |
学位論文 / Thesis or Dissertation(1) |
| 公開日 |
2010-02-22 |
| タイトル |
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|
タイトル |
Investigation of somato-motor inhibitory processing in humans using Go/No-go paradigm |
| タイトル |
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タイトル |
Investigation of somato-motor inhibitory processing in humans using Go/No-go paradigm |
|
言語 |
en |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_46ec |
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資源タイプ |
thesis |
| 著者名 |
中田, 大貴
|
| フリガナ |
ナカタ, ヒロキ
|
| 著者 |
NAKATA, Hiroki
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| 学位授与機関 |
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学位授与機関名 |
総合研究大学院大学 |
| 学位名 |
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学位名 |
博士（理学） |
| 学位記番号 |
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内容記述タイプ |
Other |
|
内容記述 |
総研大甲第1008号 |
| 研究科 |
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|
値 |
生命科学研究科 |
| 専攻 |
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|
値 |
20 生理科学専攻 |
| 学位授与年月日 |
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学位授与年月日 |
2006-09-29 |
| 学位授与年度 |
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値 |
2006 |
| 要旨 |
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内容記述タイプ |
Other |
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内容記述 |
The go/nogo task is a useful paradigm for recording event-related<br />potentials (ERPs) to investigate the neural mechanisms of response<br />inhibition. In nogo trials, a negative deflection at around 140-300 ms,<br />which has been called the ‘nogo potentials’ is elicited at the frontocentral <br />electrodes, compared with ERPs recorded in go trials. In the first study, <br />we investigated the generators for nogo potentials by recording <br />magnetoencephalography (MEG) during somatosensory go/nogo tasks. <br />MEG data revealed that a long-latency response peaking at approximately <br />160 ms, termed nogo-M170, recorded in only nogo trials. The equivalent <br />current dipole (ECD) of nogo-M170 was estimated to lie around the <br />posterior part of the inferior frontal sulci in the prefrontal cortex. This <br />finding clarified the spatial and temporal processing related to <br />somato-motor inhibition caused in the posterior part of the inferior frontal <br />sulci in the prefrontal cortex in humans.<br />In the second study, we investigated the effect of the inhibitory <br />processing with increasing muscle force on motor evoked potentials <br />(MEPs) elicited by transcranial magnetic stimulation (TMS). The <br />subjects performed a warning stimulus (S1) －imperative stimulus (S2) <br />paradigm with go/nogo tasks. S1 was an auditory tone burst, and S2 was <br />an electrical stimulation for the second (go stimuli) or fifth digit (nogo <br />stimuli) of the left hand at an even probability in go/nogo tasks. The <br />recordings were conducted at three force levels; 10 %, 30 % and 50 % <br />maximal voluntary contraction (MVC). After the presentation of S2, the <br />subjects were asked to adjust their force level so as to match the target line <br />with a force trajectory line as quickly and accurately as possible in only the <br />go trials. The amplitude of the MEP, which was recorded from the first <br />dorsal interosseous (FDI) muscle 150 ms after S2, in nogo trials became <br />significantly smaller with increasing muscle force, whereas it became <br />larger in go trials. Our results indicated that stronger inhibitory cerebral <br />activity was needed for a nogo stimulus, in the case where a stronger <br />response was needed for a go stimulus. |
| 所蔵 |
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値 |
有 |
| フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
要旨・審査要旨 (343.4 kB)
