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  1. 020 学位論文
  2. 生命科学研究科
  3. 20 生理科学専攻

Investigation of somato-motor inhibitory processing in humans using Go/No-go paradigm

https://ir.soken.ac.jp/records/1179
https://ir.soken.ac.jp/records/1179
8d625380-ae95-4130-b097-dcddae367f59
名前 / ファイル ライセンス アクション
甲1008_要旨.pdf 要旨・審査要旨 (343.4 kB)
甲1008_本文.pdf 本文 (2.2 MB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2010-02-22
タイトル
タイトル Investigation of somato-motor inhibitory processing in humans using Go/No-go paradigm
タイトル
タイトル Investigation of somato-motor inhibitory processing in humans using Go/No-go paradigm
言語 en
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_46ec
資源タイプ thesis
著者名 中田, 大貴

× 中田, 大貴

中田, 大貴

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フリガナ ナカタ, ヒロキ

× ナカタ, ヒロキ

ナカタ, ヒロキ

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著者 NAKATA, Hiroki

× NAKATA, Hiroki

en NAKATA, Hiroki

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学位授与機関
学位授与機関名 総合研究大学院大学
学位名
学位名 博士(理学)
学位記番号
内容記述タイプ Other
内容記述 総研大甲第1008号
研究科
値 生命科学研究科
専攻
値 20 生理科学専攻
学位授与年月日
学位授与年月日 2006-09-29
学位授与年度
値 2006
要旨
内容記述タイプ Other
内容記述 The go/nogo task is a useful paradigm for recording event-related<br />potentials (ERPs) to investigate the neural mechanisms of response<br />inhibition. In nogo trials, a negative deflection at around 140-300 ms,<br />which has been called the ‘nogo potentials’ is elicited at the frontocentral <br />electrodes, compared with ERPs recorded in go trials. In the first study, <br />we investigated the generators for nogo potentials by recording <br />magnetoencephalography (MEG) during somatosensory go/nogo tasks. <br />MEG data revealed that a long-latency response peaking at approximately <br />160 ms, termed nogo-M170, recorded in only nogo trials. The equivalent <br />current dipole (ECD) of nogo-M170 was estimated to lie around the <br />posterior part of the inferior frontal sulci in the prefrontal cortex. This <br />finding clarified the spatial and temporal processing related to <br />somato-motor inhibition caused in the posterior part of the inferior frontal <br />sulci in the prefrontal cortex in humans.<br />In the second study, we investigated the effect of the inhibitory <br />processing with increasing muscle force on motor evoked potentials <br />(MEPs) elicited by transcranial magnetic stimulation (TMS). The <br />subjects performed a warning stimulus (S1) -imperative stimulus (S2) <br />paradigm with go/nogo tasks. S1 was an auditory tone burst, and S2 was <br />an electrical stimulation for the second (go stimuli) or fifth digit (nogo <br />stimuli) of the left hand at an even probability in go/nogo tasks. The <br />recordings were conducted at three force levels; 10 %, 30 % and 50 % <br />maximal voluntary contraction (MVC). After the presentation of S2, the <br />subjects were asked to adjust their force level so as to match the target line <br />with a force trajectory line as quickly and accurately as possible in only the <br />go trials. The amplitude of the MEP, which was recorded from the first <br />dorsal interosseous (FDI) muscle 150 ms after S2, in nogo trials became <br />significantly smaller with increasing muscle force, whereas it became <br />larger in go trials. Our results indicated that stronger inhibitory cerebral <br />activity was needed for a nogo stimulus, in the case where a stronger <br />response was needed for a go stimulus.
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