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In nogo trials, a negative deflection at around 140-300 ms,\u003cbr /\u003ewhich has been called the ‘nogo potentials’ is elicited at the frontocentral \u003cbr /\u003eelectrodes, compared with ERPs recorded in go trials. In the first study, \u003cbr /\u003ewe investigated the generators for nogo potentials by recording \u003cbr /\u003emagnetoencephalography (MEG) during somatosensory go/nogo tasks. \u003cbr /\u003eMEG data revealed that a long-latency response peaking at approximately \u003cbr /\u003e160 ms, termed nogo-M170, recorded in only nogo trials. The equivalent \u003cbr /\u003ecurrent dipole (ECD) of nogo-M170 was estimated to lie around the \u003cbr /\u003eposterior part of the inferior frontal sulci in the prefrontal cortex. This \u003cbr /\u003efinding clarified the spatial and temporal processing related to \u003cbr /\u003esomato-motor inhibition caused in the posterior part of the inferior frontal \u003cbr /\u003esulci in the prefrontal cortex in humans.\u003cbr /\u003eIn the second study, we investigated the effect of the inhibitory \u003cbr /\u003eprocessing with increasing muscle force on motor evoked potentials \u003cbr /\u003e(MEPs) elicited by transcranial magnetic stimulation (TMS). The \u003cbr /\u003esubjects performed a warning stimulus (S1) -imperative stimulus (S2) \u003cbr /\u003eparadigm with go/nogo tasks. S1 was an auditory tone burst, and S2 was \u003cbr /\u003ean electrical stimulation for the second (go stimuli) or fifth digit (nogo \u003cbr /\u003estimuli) of the left hand at an even probability in go/nogo tasks. The \u003cbr /\u003erecordings were conducted at three force levels; 10 %, 30 % and 50 % \u003cbr /\u003emaximal voluntary contraction (MVC). After the presentation of S2, the \u003cbr /\u003esubjects were asked to adjust their force level so as to match the target line \u003cbr /\u003ewith a force trajectory line as quickly and accurately as possible in only the \u003cbr /\u003ego trials. The amplitude of the MEP, which was recorded from the first \u003cbr /\u003edorsal interosseous (FDI) muscle 150 ms after S2, in nogo trials became \u003cbr /\u003esignificantly smaller with increasing muscle force, whereas it became \u003cbr /\u003elarger in go trials. 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Investigation of somato-motor inhibitory processing in humans using Go/No-go paradigm
https://ir.soken.ac.jp/records/1179
https://ir.soken.ac.jp/records/11798d625380-ae95-4130-b097-dcddae367f59
名前 / ファイル | ライセンス | アクション |
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2010-02-22 | |||||
タイトル | ||||||
タイトル | Investigation of somato-motor inhibitory processing in humans using Go/No-go paradigm | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Investigation of somato-motor inhibitory processing in humans using Go/No-go paradigm | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_46ec | |||||
資源タイプ | thesis | |||||
著者名 |
中田, 大貴
× 中田, 大貴 |
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フリガナ |
ナカタ, ヒロキ
× ナカタ, ヒロキ |
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著者 |
NAKATA, Hiroki
× NAKATA, Hiroki |
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学位授与機関 | ||||||
学位授与機関名 | 総合研究大学院大学 | |||||
学位名 | ||||||
学位名 | 博士(理学) | |||||
学位記番号 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 総研大甲第1008号 | |||||
研究科 | ||||||
値 | 生命科学研究科 | |||||
専攻 | ||||||
値 | 20 生理科学専攻 | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2006-09-29 | |||||
学位授与年度 | ||||||
2006 | ||||||
要旨 | ||||||
内容記述タイプ | Other | |||||
内容記述 | The go/nogo task is a useful paradigm for recording event-related<br />potentials (ERPs) to investigate the neural mechanisms of response<br />inhibition. In nogo trials, a negative deflection at around 140-300 ms,<br />which has been called the ‘nogo potentials’ is elicited at the frontocentral <br />electrodes, compared with ERPs recorded in go trials. In the first study, <br />we investigated the generators for nogo potentials by recording <br />magnetoencephalography (MEG) during somatosensory go/nogo tasks. <br />MEG data revealed that a long-latency response peaking at approximately <br />160 ms, termed nogo-M170, recorded in only nogo trials. The equivalent <br />current dipole (ECD) of nogo-M170 was estimated to lie around the <br />posterior part of the inferior frontal sulci in the prefrontal cortex. This <br />finding clarified the spatial and temporal processing related to <br />somato-motor inhibition caused in the posterior part of the inferior frontal <br />sulci in the prefrontal cortex in humans.<br />In the second study, we investigated the effect of the inhibitory <br />processing with increasing muscle force on motor evoked potentials <br />(MEPs) elicited by transcranial magnetic stimulation (TMS). The <br />subjects performed a warning stimulus (S1) -imperative stimulus (S2) <br />paradigm with go/nogo tasks. S1 was an auditory tone burst, and S2 was <br />an electrical stimulation for the second (go stimuli) or fifth digit (nogo <br />stimuli) of the left hand at an even probability in go/nogo tasks. The <br />recordings were conducted at three force levels; 10 %, 30 % and 50 % <br />maximal voluntary contraction (MVC). After the presentation of S2, the <br />subjects were asked to adjust their force level so as to match the target line <br />with a force trajectory line as quickly and accurately as possible in only the <br />go trials. The amplitude of the MEP, which was recorded from the first <br />dorsal interosseous (FDI) muscle 150 ms after S2, in nogo trials became <br />significantly smaller with increasing muscle force, whereas it became <br />larger in go trials. Our results indicated that stronger inhibitory cerebral <br />activity was needed for a nogo stimulus, in the case where a stronger <br />response was needed for a go stimulus. | |||||
所蔵 | ||||||
値 | 有 | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf |