{"_buckets": {"deposit": "fa515697-c1d4-4685-a1b8-526aaa33315b"}, "_deposit": {"created_by": 21, "id": "3246", "owners": [21], "pid": {"revision_id": 0, "type": "depid", "value": "3246"}, "status": "published"}, "_oai": {"id": "oai:ir.soken.ac.jp:00003246", "sets": ["265"]}, "author_link": ["415", "354", "418"], "item_8_biblio_info_26": {"attribute_name": "書誌情報（ソート用）", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2009", "bibliographicIssueDateType": "Issued"}, "bibliographic_titles": [{}]}]}, "item_8_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2009", "bibliographicIssueDateType": "Issued"}, "bibliographic_titles": [{}]}]}, "item_8_creator_4": {"attribute_name": "フリガナ", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "ササキ, アキラ"}], "nameIdentifiers": [{"nameIdentifier": "418", "nameIdentifierScheme": "WEKO"}]}]}, "item_8_description_10": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "研究課題名：物理を基礎とする生命科学", "subitem_description_type": "Other"}]}, "item_8_description_21": {"attribute_name": "フォーマット", "attribute_value_mlt": [{"subitem_description": "application/pdf", "subitem_description_type": "Other"}]}, "item_8_description_9": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "インフノレエンザウィノレス, AIDS ウィノレス,トリパノソーマなど急速に進化す\r\nる病原体は,ワクチンや薬剤に対する抵抗性を急速に進化させ,また宿主免疫\r\nの攻撃目標となるエピトープを変えることによって,ワクチン接種や自然免疫\r\nからエスケープする.表面抗原の特定の領域のアミノ酸配列で定義されるエピ\r\nトープは,宿主免疫系との強い相互作用による頻度依存淘汰を受け,多次元配\r\n列空間のなかを「予測不可能な」軌跡を描いて進化し,また系統樹上の新しい\r\n枝が分岐し,多様化する.このような病原体の表現型(抗原型)と配列の進化\r\nを取り扱うための数学的理論はまだ確立されておらず,有効な流行予測や防除\r\n政策立案を阻むおおきな問題点となっている.本研究課題では,申請者が開発\r\nしてきた宿主と病原体の共進化理論や,病原体の配列進化・系統樹分岐理論を\r\n発展させ,宿主の集団免疫構造と病原体エピトープの共進化を数理モデル化し,\r\n流行と進化の予測を可能にする理論の構築を試みた.", "subitem_description_type": "Abstract"}]}, "item_8_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "葉山高等研究所センター"}]}, "item_8_version_type_22": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "佐々木, 顕"}], "nameIdentifiers": [{"nameIdentifier": "354", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "SASAKI, Akira ", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "415", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2012-11-27"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "sasaki.pdf", "filesize": [{"value": "879.3 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_11", "mimetype": "application/pdf", "size": 879300.0, "url": {"label": "sasaki", "url": "https://ir.soken.ac.jp/record/3246/files/sasaki.pdf"}, "version_id": "63ca7966-6300-4c79-9531-e05546fbbf96"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "research report", "resourceuri": "http://purl.org/coar/resource_type/c_18ws"}]}, "item_title": "病原体の進化予卸上表現型とエピトープ配列の進化動態", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "病原体の進化予卸上表現型とエピトープ配列の進化動態"}]}, "item_type_id": "8", "owner": "21", "path": ["265"], "permalink_uri": "https://ir.soken.ac.jp/records/3246", "pubdate": {"attribute_name": "公開日", "attribute_value": "2012-11-26"}, "publish_date": "2012-11-26", "publish_status": "0", "recid": "3246", "relation": {}, "relation_version_is_last": true, "title": ["病原体の進化予卸上表現型とエピトープ配列の進化動態"], "weko_shared_id": -1}