| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2013-09-25 |
| タイトル |
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タイトル |
Analysis by fluorescence in situ hybridization with a mouse gamma satellite DNA probe of isolated micronuclei induced in mice by two clastogens and two spindle poisons |
| タイトル |
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タイトル |
Analysis by fluorescence in situ hybridization with a mouse gamma satellite DNA probe of isolated micronuclei induced in mice by two clastogens and two spindle poisons |
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言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
metadata only access |
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アクセス権URI |
http://purl.org/coar/access_right/c_14cb |
| 著者 |
MäKI-PAAKKANEN, Jorma
HAYASHI, Makoto
SUZUKI, Takayoshi
TANABE, Hideyuki
HONMA, Masamitsu
SOFUNI, Toshio
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| 著者別名 |
田辺, 秀之
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
The presence of centromeric DNA was studied in micronuclei isolated from the blood of male ddY mic after five weekly intraperitoneal injections of mitomycu C (MMC), 1-β-D-arabinofuranosylcytosine (Ara-C), colchi cine (COL) or vinblastine sulfate (VBL). In agreement with our earlier findings, about half of the micronuclei isolate* from vehicle control mice showed centromere signals a analyzed by fluorescence in situ hybridization (FISH) with a mouse major (gamma) satellite DNA probe. In an earlie experiment with mice acutely exposed to the same chem icals, the clastogens MMC and Ara-C did not reduce thi proportion of micronuclei with centromere signals. In the present study, however, MMC and Ara-C decreased the proportion of micronuclei with centromeres. In contrast the spindle poisons COL and VBL increased the proportion of micronuclei that contained centromeres. |
| 書誌情報 |
Mutagenesis
en : Mutagenesis
巻 10,
号 6,
p. 513-516,
発行日 1995-11
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| 出版者 |
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出版者 |
Oxford University Press |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0267-8357 |
| DOI |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1093/mutage/10.6.513 |
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関連名称 |
10.1093/mutage/10.6.513 |
| 権利 |
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権利情報 |
© Oxford University Press |
