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Analysis by fluorescence in situ hybridization with a mouse gamma satellite DNA probe of isolated micronuclei induced in mice by two clastogens and two spindle poisons
https://ir.soken.ac.jp/records/3987
https://ir.soken.ac.jp/records/39877bc3cb21-b32d-4537-8b7e-9a4f7de40976
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-09-25 | |||||
| タイトル | ||||||
| タイトル | Analysis by fluorescence in situ hybridization with a mouse gamma satellite DNA probe of isolated micronuclei induced in mice by two clastogens and two spindle poisons | |||||
| タイトル | ||||||
| タイトル | Analysis by fluorescence in situ hybridization with a mouse gamma satellite DNA probe of isolated micronuclei induced in mice by two clastogens and two spindle poisons | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
MäKI-PAAKKANEN, Jorma
× MäKI-PAAKKANEN, Jorma× HAYASHI, Makoto× SUZUKI, Takayoshi× TANABE, Hideyuki× HONMA, Masamitsu× SOFUNI, Toshio |
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| 著者別名 |
田辺, 秀之
× 田辺, 秀之 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The presence of centromeric DNA was studied in micronuclei isolated from the blood of male ddY mic after five weekly intraperitoneal injections of mitomycu C (MMC), 1-β-D-arabinofuranosylcytosine (Ara-C), colchi cine (COL) or vinblastine sulfate (VBL). In agreement with our earlier findings, about half of the micronuclei isolate* from vehicle control mice showed centromere signals a analyzed by fluorescence in situ hybridization (FISH) with a mouse major (gamma) satellite DNA probe. In an earlie experiment with mice acutely exposed to the same chem icals, the clastogens MMC and Ara-C did not reduce thi proportion of micronuclei with centromere signals. In the present study, however, MMC and Ara-C decreased the proportion of micronuclei with centromeres. In contrast the spindle poisons COL and VBL increased the proportion of micronuclei that contained centromeres. | |||||
| 書誌情報 |
Mutagenesis en : Mutagenesis 巻 10, 号 6, p. 513-516, 発行日 1995-11 |
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| 出版者 | ||||||
| 出版者 | Oxford University Press | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0267-8357 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1093/mutage/10.6.513 | |||||
| 関連名称 | 10.1093/mutage/10.6.513 | |||||
| 権利 | ||||||
| 権利情報 | © Oxford University Press | |||||
