{"_buckets": {"deposit": "4871320e-d5bb-42e9-ac01-11898f8426fe"}, "_deposit": {"created_by": 24, "id": "5739", "owners": [24], "pid": {"revision_id": 0, "type": "depid", "value": "5739"}, "status": "published"}, "_oai": {"id": "oai:ir.soken.ac.jp:00005739", "sets": ["34"]}, "author_link": ["10387", "10386"], "item_2_creator_3": {"attribute_name": "著者名(英)", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "OKADA, Yasunobu", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "10387", "nameIdentifierScheme": "WEKO"}]}]}, "item_2_date_4": {"attribute_name": "発行日", "attribute_value_mlt": [{"subitem_date_issued_datetime": "2017-08-31", "subitem_date_issued_type": "Created"}]}, "item_2_description_13": {"attribute_name": "研究課題番号", "attribute_value_mlt": [{"subitem_description": "15K15028", "subitem_description_type": "Other"}]}, "item_2_description_14": {"attribute_name": "フォーマット", "attribute_value_mlt": [{"subitem_description": "application/pdf", "subitem_description_type": "Other"}]}, "item_2_description_16": {"attribute_name": "研究期間", "attribute_value_mlt": [{"subitem_description": "2015～2016", "subitem_description_type": "Other"}]}, "item_2_description_17": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "研究成果の概要(和文):LRRC8Aがヒト細胞の容積感受性外向整流性アニオンチャネルVSORの重要構成分子であることが報告された。本研究では、①LRRC8Aは、マウス細胞のVSORにおいても本質的な役割を果たすこと、②本分子の関与は、酸感受性外向整流性アニオンチャネル（ASOR）、マキシアニオンチャネル（Maxi-Cl）、Ca2+賦活性アニオンチャネル（CaCC）やcAMP賦活性アニオンチャネル（CFTR）には見られず、VSOR特異的であること、しかし、③シスプラチン耐性がん細胞KCP-4のVSOR活性欠乏の原因には、LRRC8AやLRRC8B～Eは関与せず、未知の他分子の関与が不可欠であることを明らかにした。 \n研究成果の概要(英文):Recently, LRRC8A was reported to be the essential component of human volume-sensitive outwardly rectifying anion channel(VSOR). In this study, we have elucidated that LRRC8A is also essentially involved in mouse VSOR activity, whereas it is not involved in the activities of 4 other types of anion channels activated by acid, Ca2+, patch excision or cAMP, respectively. Also, we have shown that deficiency of VSOR activity in KCP-4 cells is not due to insufficient expression of LRRC8A/B/C/D/E, suggesting an involvement of some other molecule(s) in VSOR activity.  \n", "subitem_description_type": "Abstract"}]}, "item_2_description_18": {"attribute_name": "科研費研究者番号", "attribute_value_mlt": [{"subitem_description": "10025661 | https://nrid.nii.ac.jp/ja/nrid/1000010025661/", "subitem_description_type": "Other"}]}, "item_2_description_6": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "科学研究費補助金研究成果報告書\n研究代表者:岡田泰伸[総合研究大学院大学学長]", "subitem_description_type": "Other"}]}, "item_2_relation_11": {"attribute_name": "関連サイト", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "KAKEN（科学研究費補助金データーベース）"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K15028/", "subitem_relation_type_select": "URI"}}]}, "item_2_text_19": {"attribute_name": "研究分野", "attribute_value_mlt": [{"subitem_text_value": "生理学一般"}]}, "item_2_text_20": {"attribute_name": "研究種目", "attribute_value_mlt": [{"subitem_text_value": "挑戦的萌芽研究 "}]}, "item_2_text_5": {"attribute_name": "報告年度", "attribute_value_mlt": [{"subitem_text_value": "2016"}]}, "item_2_version_type_12": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "岡田, 泰伸"}], "nameIdentifiers": [{"nameIdentifier": "10386", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-05-25"}], "displaytype": "simple", "download_preview_message": "", "file_order": 0, "filename": "15K15028seika_okada.pdf", "filesize": [{"value": "716.2 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_11", "mimetype": "application/pdf", "size": 716200.0, "url": {"label": "研究成果報告書", "url": "https://ir.soken.ac.jp/record/5739/files/15K15028seika_okada.pdf"}, "version_id": "98ce987b-33f3-4bbd-89ee-cf0c37aa50f0"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "アニオンチャネル", "subitem_subject_scheme": "Other"}, {"subitem_subject": "細胞容積調節", "subitem_subject_scheme": "Other"}, {"subitem_subject": "タンパク質－タンパク質相互作用", "subitem_subject_scheme": "Other"}, {"subitem_subject": "細胞生理学", "subitem_subject_scheme": "Other"}, {"subitem_subject": "生理学", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "research report", "resourceuri": "http://purl.org/coar/resource_type/c_18ws"}]}, "item_title": "容積感受性アニオンチャネルVSORと新規関連タンパク質LRRC8Aの相互作用機構", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "容積感受性アニオンチャネルVSORと新規関連タンパク質LRRC8Aの相互作用機構"}, {"subitem_title": "Mechanisms of interaction between the volume-sensitive outwardly rectifying anion channel, VSOR and a novel membrane protein,LRRC8A.", "subitem_title_language": "en"}]}, "item_type_id": "2", "owner": "24", "path": ["34"], "permalink_uri": "https://ir.soken.ac.jp/records/5739", "pubdate": {"attribute_name": "公開日", "attribute_value": "2018-05-25"}, "publish_date": "2018-05-25", "publish_status": "0", "recid": "5739", "relation": {}, "relation_version_is_last": true, "title": ["容積感受性アニオンチャネルVSORと新規関連タンパク質LRRC8Aの相互作用機構"], "weko_shared_id": -1}